Recombinant Rat Sirt6 protein, His-tagged
Cat.No. : | Sirt6-1382R |
Product Overview : | Recombinant Rat Sirt6 aa. (Asn88~Pro288 (Accession # Q4FZY2) fused with N-terminal His tag was produced in E. coli cells. |
- Specification
- Gene Information
- Related Products
Source : | E. coli |
Species : | Rat |
Tag : | His |
Form : | Freeze-dried powder |
Molecular Mass : | 25kDa as determined by SDS-PAGE reducing conditions. |
Protein length : | Asn88~Pro288 (Accession # Q4FZY2) |
Endotoxin : | <1.0EU per 1µg (determined by the LAL method) |
Purity : | >95% |
Characteristic : | The isoelectric point is 8.8. |
Applications : | SDS-PAGE; WB; ELISA; IP. |
Stability : | The thermal stability is described by the loss rate of the target protein. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed. (Referring from China Biological Products Standard, which was calculated by the Arrhenius equation.) The loss of this protein is less than 5% within the expiration date under appropriate storage condition. |
Storage : | Avoid repeated freeze/thaw cycles. Store at 2-8°C for one month. Aliquot and store at -80°C for 12 months. |
Storage buffer : | Supplied as lyophilized form in PBS, pH 7.4, containing 5% sucrose, 0.01% sarcosyl. |
Reconstitution : | Reconstitute in sterile PBS, pH7.2-pH7.4. |
Gene Name : | Sirt6 sirtuin 6 [ Rattus norvegicus (Norway rat) ] |
Official Symbol : | Sirt6 |
Synonyms : | Sirt6; sirtuin 6; NAD-dependent protein deacetylase sirtuin-6; NAD-dependent deacetylase sirtuin-6 |
Gene ID : | 299638 |
mRNA Refseq : | NM_001031649.1 |
Protein Refseq : | NP_001026819.1 |
UniProt ID : | Q4FZY2 |
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Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (6)
Ask a questionSIRT6 can participate in the DNA repair process by influencing the activity of DNA repair enzymes through deacetylation modification.
This proteinexpression of genes related to fat metabolism through deacetylation modifications.
Yes, SIRT6 has therapeutic potential. In tumor therapy, drug activation or gene therapy targeting SIRT6 may become a new avenue for treating tumors. At the same time, activators for SIRT6 are also being developed.
SIRT6 regulates the expression of specific genes through deacetylation, which in turn affects nutrient metabolism and energy balance. For example, in adipocytes, activation of SIRT6 may lead to abnormal expression of genes related to adipopocyte, which in turn affects processes such as differentiation, proliferation, and apoptosis of adipocytes.
Deletion of SIRT6 may lead to cell growth arrest, increased apoptosis, and genomic instability.
There are differences in the expression levels of SIRT6 in different tissues and cells. For example, in tissues and cells such as the reproductive system, nervous system, and immune system, there may be varying degrees of variation in the expression levels of SIRT6.
Customer Reviews (3)
Write a reviewThis protein has high yield and good economic benefits.
Laboratory staff feedback that the protein is easy to operate, can meet the needs of the experiment, and has a good cost performance.
SIRT6 is highly expressed and can efficiently synthesize a large number of target proteins in host cells.
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