SKP2

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SKP2

Official Full Name S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
Background This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbls class; in addition to an F-box, this protein contains 10 tandem leucine-rich repeats. This protein is an essential element of the cyclin A-CDK2 S-phase kinase. It specifically recognizes phosphorylated cyclin-dependent kinase inhibitor 1B (CDKN1B, also referred to as p27 or KIP1) predominantly in S phase and interacts with S-phase kinase-associated protein 1 (SKP1 or p19). In addition, this gene is established as a protooncogene causally involved in the pathogenesis of lymphomas. Alternative splicing of this gene generates three transcript variants encoding different isoforms. [provided by RefSeq, Jul 2011]
Synonyms SKP2; S-phase kinase-associated protein 2, E3 ubiquitin protein ligase; p45; FBL1; FLB1; FBXL1; S-phase kinase-associated protein 2; p45skp2; F-box/LRR-repeat protein 1; CDK2/cyclin A-associated protein p45; S-phase kinase-associated protein 2 (p45);
    • Species :
    • Chicken
    • Human
    • Zebrafish
    • Source :
    • E.coli
    • HEK293
    • Human
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • T7
    • Myc
    • DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human SKP2-012H Recombinant Human SKP2 Protein, His-tagged E.coli His
    Human SKP2-1465H Recombinant Human S-Phase Kinase-Associated Protein 2 (p45), GST-tagged Human GST
    Human SKP2-1812HCL Recombinant Human SKP2 293 Cell Lysate HEK293 N/A
    Human SKP2-31723TH Recombinant Human SKP2 Wheat Germ N/A
    Human SKP2-36H Recombinant Human SKP2 protein, His/T7-tagged E.coli His/T7
    Human SKP2-42H Recombinant Human SKP2 protein, MYC/DDK-tagged HEK293 Myc/DDK
    Human SKP2-684H Recombinant Human S-phase Kinase-associated Protein 2 (p45) E.coli N/A
    Chicken SKP2-1819C Recombinant Chicken SKP2 Mammalian Cell His
    Zebrafish SKP2-5233Z Recombinant Zebrafish SKP2 Mammalian Cell His

    SKP2 involved in several pathways and played different roles in them. We selected most pathways SKP2 participated on our site, such as content, which may be useful for your reference. Also, other proteins which involved in the same pathway with SKP2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    FoxO signaling pathway SGK1; GRB2A; HOMER3; SGK2A; KRAS; PRKAG3; G6PC; TGFBR1B; MAPK8A; TNFSF10
    Cell cycle ORC6L; YWHAE2; PLK4; OIP5; CDC20; RAD9A; E2F4; CCNE1; CDC14A; AURKB
    Ubiquitin mediated proteolysis SIAH2L; UBE2B; PIAS1; FBXW11; UBE2L3B; UBOX5; ANAPC4; UBE2G1; BRCA1; SOCS1
    Herpes simplex infection TRAF2; CLOCKA; IRF7; GLTSCR2; SRSF1; HLA-DRB3; NFKBIB; MHC1UEA; ARNTL1A; PTPN11
    Epstein-Barr virus infection CSNK2A2; IFNG; HLA-DQB1; TRAF2; HSPA1L; PSMD11; PSMC3; PRKACA; TRAF1; AKAP8L
    Pathways in cancer BAX; RXRB; SMAD4; SFPI1; PTCH2; PTEN; MAPK1; ABL1; FGFR1; LAMA5
    Viral carcinogenesis CREB3L1; SCIN; ACTN3; GTF2H2; PKM; HIST1H4A; NFKB1; HIST1H4L; PKM2; STAT5B
    Small cell lung cancer LAMC1; LAMC2; TRAF4; CYCS; LAMB4; LAMA3; ITGA6; CCNE2; PIK3CG; PIK3CD

    SKP2 has several biochemical functions, for example, Content. Some of the functions are cooperated with other proteins, some of the functions could acted by SKP2 itself. We selected most functions SKP2 had, and list some proteins which have the same functions with SKP2. You can find most of the proteins on our site.

    Function Related Protein
    identical protein binding GBP5; VWF; CCDC91; CLPP; TRIM39; AGXT2L1; MBIP; MDM2; PCM1; DES
    protein binding PPP3CB; WASF1; TEC; PRPF40A; COMMD3; PBX4; LAMA4; RNF182; RHOT1; ZUFSP
    contributes_to ubiquitin protein ligase activity FBXL7; FBXL3B; FBXL15; UBXN6; ANAPC2; FBXL5; FBXL14A; KDM2BA; FBXL4; CUL4B

    SKP2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SKP2 here. Most of them are supplied by our site. Hope this information will be useful for your research of SKP2.

    SKP1; CDK2

    Matsushita, H; Hosoi, A; et al. Cytotoxic T Lymphocytes Block Tumor Growth Both by Lytic Activity and IFN gamma-Dependent Cell-Cycle Arrest. CANCER IMMUNOLOGY RESEARCH 3:26-36(2015).
    Dombrowski, C; Helledie, T; et al. FGFR1 Signaling Stimulates Proliferation of Human Mesenchymal Stem Cells by Inhibiting the Cyclin-Dependent Kinase Inhibitors p21(Waf1) and p27(Kip1). STEM CELLS 31:2724-2736(2013).

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