slc11a2
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  • Official Full Name
  • solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2
  • Background
  • This gene encodes a member of the solute carrier family 11 protein family. The product of this gene transports divalent metals and is involved in iron absorption. Mutations in this gene are associated with hypochromic microcytic anemia with iron overload. A related solute carrier family 11 protein gene is located on chromosome 2. Multiple transcript variants encoding different isoforms have been found for this gene.
  • Synonyms
  • SLC11A2; solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2; NRAMP2; natural resistance-associated macrophage protein 2; DCT1; DMT1; DMT-1; NRAMP 2; divalent cation transporter 1; FLJ37416
Cat.#:SLC11A2-2696HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human SLC11A2, GST-tagged
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Cat.#:SLC11A2-15206MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse SLC11A2 Protein
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Cat.#:SLC11A2-4218RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey SLC11A2 Protein, His-tagged
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Cat.#:SLC11A2-3846CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken SLC11A2
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Cat.#:SLC11A2-3847CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken SLC11A2
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Cat.#:SLC11A2-3791ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish SLC11A2
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Involved Pathway

SLC11A2 involved in several pathways and played different roles in them. We selected most pathways SLC11A2 participated on our site, such as Lysosome, Mineral absorption, which may be useful for your reference. Also, other proteins which involved in the same pathway with SLC11A2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Lysosome
GNSA; CTSC; ATP6V0A1A; PSAPL1; ARSA; CTSSA; ENTPD4; ATP6AP1B; NEU1; ATP6AP1
Mineral absorption
SLC46A1; Trf; SLC40A1; MT2A; MT1H; TRPM6; MT1A; ATP1A2; MT1F; CLCN2

Protein Function

SLC11A2 has several biochemical functions, for example, cadmium ion binding, cadmium ion transmembrane transporter activity, NOT calcium ion transmembrane transporter activity. Some of the functions are cooperated with other proteins, some of the functions could acted by SLC11A2 itself. We selected most functions SLC11A2 had, and list some proteins which have the same functions with SLC11A2. You can find most of the proteins on our site.
Function
Related Protein
Function cadmium ion binding
Related Protein SLC11A2; MT3; NOS3; NOS1; P2RX2
Function cadmium ion transmembrane transporter activity
Related Protein SLC11A2
Function NOT calcium ion transmembrane transporter activity
Related Protein SLC11A2
Function NOT chromium ion transmembrane transporter activity
Related Protein SLC11A2
Function cobalt ion binding
Related Protein SLC11A2; NUDT16; P2RX2; BIRC5; PML
Function cobalt ion transmembrane transporter activity
Related Protein SLC11A2; MMGT2
Function copper ion binding
Related Protein LOXL3B; S100V2; POLR1B; SOD3A; CCS; HEPHL1A; AOC3; CP; PRND; AOC1
Function copper ion transmembrane transporter activity
Related Protein ATOX1; SLC11A2; ATP7A; MMGT2; SLC31A2; SLC31A1
Function ferrous iron transmembrane transporter activity
Related Protein SLC39A14; SLC11A2; SLC40A1
Function ferrous iron uptake transmembrane transporter activity
Related Protein SLC11A2
Function hydrogen ion transmembrane transporter activity
Related Protein ATP5G3A; ATP6V0A2B; ATP5S; ATP6V0E; mt-Atp8; ATP6V1F; ATP6V1C1A; ATP6V1AA; ATP5H; ATP5IB
Function inorganic cation transmembrane transporter activity
Related Protein SLC39A1; SLC11A2; MMGT2
Function iron ion binding
Related Protein EGLN1; CYP2C37; CYP8B3; TPH1; CYP2X7; AOX3; CYP2K19; CYP4A14; JMJD6; CYP4T8
Function lead ion transmembrane transporter activity
Related Protein SLC11A2
Function manganese ion binding
Related Protein SLC11A2; LAP3; PPM1BB; PIM1; PCK1; PPM1AB; ARG1; GALNT1; PPM1NB; GALNT2
Function manganese ion transmembrane transporter activity
Related Protein MMGT2; SLC11A1; SLC11A2; ZP3; TRPM2
Function nickel cation binding
Related Protein P2RX2; CAR3; SLC11A2; CA3
Function nickel cation transmembrane transporter activity
Related Protein SLC11A2; MMGT2
Function protein binding
Related Protein GOLGA1; CPSF4; SYCE2; UBE4A; KLF2; SLC6A20; ZC3H11A; CCR3; AP1G1; CCDC86
Function solute:proton symporter activity
Related Protein SLC11A2; MFSD3; SLC33A1
Function transferrin transmembrane transporter activity
Related Protein TFRC; SLC11A2
Function transition metal ion transmembrane transporter activity
Related Protein SLC11A1; SLC11A2
Function vanadium ion transmembrane transporter activity
Related Protein SLC11A2
Function zinc ion binding
Related Protein GTF2H2; MARCH3; OTUD7A; CXXC5; S100A7; RAI1; ADAM17A; TRAF4; CNBPA; ZDHHC13
Function zinc ion transmembrane transporter activity
Related Protein SLC39A13; SLC39A14; SLC30A2; SLC30A4; SLC39A11; SLC39A10; SLC30A1A; SLC39A1; SLC30A8; SLC39A7
Function NOT zinc ion transmembrane transporter activity
Related Protein SLC11A2

Interacting Protein

SLC11A2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SLC11A2 here. Most of them are supplied by our site. Hope this information will be useful for your research of SLC11A2.
MT-CO2; b3xyc5_sollc

SLC11A2 Related Articles

Latunde-Dada, GO; Pereira, DIA; et al. A Nanoparticulate Ferritin-Core Mimetic Is Well Taken Up by HuTu 80 Duodenal Cells and Its Absorption in Mice Is Regulated by Body Iron. JOURNAL OF NUTRITION 144:1896-1902(2014).
Garrick, MD; Kuo, HC; et al. Comparison of mammalian cell lines expressing distinct isoforms of divalent metal transporter 1 in a tetracycline-regulated fashion. BIOCHEMICAL JOURNAL 398:539-546(2006).