SLC11A2

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SLC11A2

Official Full Name solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2
Background This gene encodes a member of the solute carrier family 11 protein family. The product of this gene transports divalent metals and is involved in iron absorption. Mutations in this gene are associated with hypochromic microcytic anemia with iron overload. A related solute carrier family 11 protein gene is located on chromosome 2. Multiple transcript variants encoding different isoforms have been found for this gene.
Synonyms SLC11A2; solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2; NRAMP2; natural resistance-associated macrophage protein 2; DCT1; DMT1; DMT-1; NRAMP 2; divalent cation transporter 1; FLJ37416
    • Species :
    • Chicken
    • Human
    • Mouse
    • Rhesus Macaque
    • Zebrafish
    • Source :
    • E.coli
    • Mammalian Cell
    • Tag :
    • GST
    • His
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human SLC11A2-2696H Recombinant Human SLC11A2, GST-tagged E.coli GST
    Mouse SLC11A2-15206M Recombinant Mouse SLC11A2 Protein Mammalian Cell His
    Rhesus Macaque SLC11A2-4218R Recombinant Rhesus monkey SLC11A2 Protein, His-tagged Mammalian Cell His
    Chicken SLC11A2-3846C Recombinant Chicken SLC11A2 Mammalian Cell His
    Chicken SLC11A2-3847C Recombinant Chicken SLC11A2 Mammalian Cell His
    Zebrafish SLC11A2-3791Z Recombinant Zebrafish SLC11A2 Mammalian Cell His

    SLC11A2 involved in several pathways and played different roles in them. We selected most pathways SLC11A2 participated on our site, such as Lysosome, Mineral absorption, which may be useful for your reference. Also, other proteins which involved in the same pathway with SLC11A2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Lysosome TCEAL4; CTSBB; AP4M1; HEXB; ATP6V0A2; GALCB; Ctsl; AP1S3; NPC1; DNASE2
    Mineral absorption S100G; STEAP2; STEAP1; MT2; CLCN2; TF; MT1X; MT2A; SLC26A9; SLC31A1

    SLC11A2 has several biochemical functions, for example, cadmium ion binding, cadmium ion transmembrane transporter activity, NOT calcium ion transmembrane transporter activity. Some of the functions are cooperated with other proteins, some of the functions could acted by SLC11A2 itself. We selected most functions SLC11A2 had, and list some proteins which have the same functions with SLC11A2. You can find most of the proteins on our site.

    Function Related Protein
    cadmium ion binding NOS3; MT3; P2RX2; SLC11A2; NOS1
    cadmium ion transmembrane transporter activity SLC11A2
    NOT calcium ion transmembrane transporter activity SLC11A2
    NOT chromium ion transmembrane transporter activity SLC11A2
    cobalt ion binding PML; P2RX2; SLC11A2; NUDT16; BIRC5
    cobalt ion transmembrane transporter activity MMGT2; SLC11A2
    copper ion binding ATP7B; METTL17; PRND; S100A13; TRP53; ATOX1; PRNP; F8; PAM; LOXL3
    copper ion transmembrane transporter activity SLC31A2; SLC11A2; ATP7A; MMGT2; ATOX1; SLC31A1
    ferrous iron transmembrane transporter activity SLC11A2; SLC39A14; SLC40A1
    ferrous iron uptake transmembrane transporter activity SLC11A2
    hydrogen ion transmembrane transporter activity ATP6V0D2; ATP5L; ATP6V0A1B; ATP6V0E2; ATP5G3A; ATP6V0A2B; ATP6V0E; ATP5H; ATP6V0CA; SLC36A1
    inorganic cation transmembrane transporter activity SLC11A2; SLC39A1; MMGT2
    iron ion binding HBA1; CYP7A1; SLC11A2; CYP2AA6; LEPRE1; CYP4V8; CYP2AA12; CYP2AA9; HBBE3; FA2H
    lead ion transmembrane transporter activity SLC11A2
    manganese ion binding FEN1; PPM1M; PIM1; PPM1B; B4GALT7; DYRK2; PPM1BA; PPM1A; PPEF1; MRE11A
    manganese ion transmembrane transporter activity MMGT2; TRPM2; SLC11A2; ZP3; SLC11A1
    nickel cation binding CAR3; P2RX2; CA3; SLC11A2
    nickel cation transmembrane transporter activity MMGT2; SLC11A2
    protein binding SH3YL1; DEPDC6; FAM117B; LYRM2; PAF1; NSUN4; ZNF34; TRIM71; HUWE1; GPR19
    solute:proton symporter activity MFSD3; SLC11A2; SLC33A1
    transferrin transmembrane transporter activity TFRC; SLC11A2
    transition metal ion transmembrane transporter activity SLC11A2; SLC11A1
    vanadium ion transmembrane transporter activity SLC11A2
    zinc ion binding QPCT; ZDHHC6; APOBEC2B; MMP28; LIMK1A; NR2F1B; EP300; CPXM1; DHX58; LIMS3
    zinc ion transmembrane transporter activity SLC30A1B; SLC39A1; SLC30A1; SLC39A13; SLC39A10; SLC39A12; SLC30A4; SLC39A2; SLC30A8; SLC39A7
    NOT zinc ion transmembrane transporter activity SLC11A2

    SLC11A2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SLC11A2 here. Most of them are supplied by our site. Hope this information will be useful for your research of SLC11A2.

    MT-CO2; b3xyc5_sollc

    Latunde-Dada, GO; Pereira, DIA; et al. A Nanoparticulate Ferritin-Core Mimetic Is Well Taken Up by HuTu 80 Duodenal Cells and Its Absorption in Mice Is Regulated by Body Iron. JOURNAL OF NUTRITION 144:1896-1902(2014).
    Garrick, MD; Kuo, HC; et al. Comparison of mammalian cell lines expressing distinct isoforms of divalent metal transporter 1 in a tetracycline-regulated fashion. BIOCHEMICAL JOURNAL 398:539-546(2006).

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