smad2
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  • Official Full Name
  • SMAD family member 2
  • Background
  • SMAD2 or Mothers against decapentaplegic homolog 2 is a polypeptide that, as its name describes, is a homolog of the Drosophila gene: Mothers against decepentaplegic. It belongs to the SMAD family of proteins, which belong to the TGFbeta superfamily of modulators. Like many other TGFbeta family members SMAD2 is involved in cell signalling. SMAD2 modulates signals of activin and TGFbeta's. It interacts with SMAD anchor for receptor activation (SARA). The binding of ligands causes the phosphorylation of the SMAD2 protein and the dissociation from SARA and the association with SMAD4. It is subsequently transferred to the nucleus where it forms complexes with other proteins and acts as a transcription factor. SMAD2 is a receptor regulated SMAD (R-SMAD) and is activated by bone morphogenetic protein type 1 receptor kinase.
  • Synonyms
  • SMAD2; SMAD family member 2; MAD, mothers against decapentaplegic homolog 2 (Drosophila) , MADH2, SMAD, mothers against DPP homolog 2 (Drosophila); mothers against decapentaplegic homolog 2; JV18 1; MADR2; MAD homolog 2; mother against DPP homolog 2; Sma- and Mad-related protein 2; SMAD, mothers against DPP homolog 2; JV18; MADH2; JV18-1; hMAD-2; hSMAD2; MGC22139; MGC34440
Cat.#:SMAD2-1915HTag:Myc|DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human SMAD2 Protein, MYC/DDK-tagged
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Cat.#:SMAD2-306HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human SMAD2 Protein, His-tagged
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Cat.#:Smad2-307MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Smad2 Protein, His-tagged
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Cat.#:SMAD2-118HTag:T7|His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human SMAD2 protein, T7/His-tagged
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Cat.#:SMAD2-294HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human SMAD2 protein, GST-tagged
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Cat.#:SMAD2-30446THTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human SMAD2, His-tagged
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Cat.#:SMAD2-30447THTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human SMAD2
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Cat.#:SMAD2-324HTag:His|MBP
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human SMAD2 protein, His/MBP-tagged
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Cat.#:SMAD2-392HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human SMAD Family Member 2, His-tagged
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Cat.#:SMAD2-901MTag:GST|His
Source (Host):Baculovirus-Insect CellsSpecies:Mouse
Product nameRecombinant Mouse SMAD2 Protein, GST & His-tagged
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Cat.#:SMAD2-5607RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat SMAD2 Protein
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Cat.#:SMAD2-4330RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey SMAD2 Protein, His-tagged
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Cat.#:SMAD2-6130CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken SMAD2
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Cat.#:SMAD2-8420ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish SMAD2
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Cat.#:SMAD2-1093HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human SMAD Family Member 2, GST-tagged
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Cat.#:SMAD5-1096HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human SMAD Family Member 5, GST-tagged
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Cat.#:SMAD2-001MCLTag:N/A
Source (Host):Baculovirus-Insect CellsSpecies:Mouse
Product nameRecombinant Mouse SMAD2 cell lysate
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Involved Pathway

SMAD2 involved in several pathways and played different roles in them. We selected most pathways SMAD2 participated on our site, such as FoxO signaling pathway, Cell cycle, Endocytosis, which may be useful for your reference. Also, other proteins which involved in the same pathway with SMAD2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
FoxO signaling pathway
CDKN2D; GRB2; GADD45B; PIK3CB; HOMER1; PRKAG2A; INS2; MAPK8A; CCNB1; PCK2
Cell cycle
ANAPC4; TBC1D8; MAD2L1; GSK3AA; ORC3L; CHEK2; RAD50; VRK1; DYNC1H1; ENSAB
Endocytosis
WASH; CDC42L2; VPS45; VPS26BL; CSF1R; VPS37A; IGF2R; SH3GL1; VPS35; RAB7
TGF-beta signaling pathway
BMP2B; SMAD4; BMPR1B; ID1; INHBB; MAPK3; BMPR1AB; IFNG; ACVR1BA; BMPR2
Hippo signaling pathway
AXIN2; LLGL2; CTGF; FZD5; WNT11; TGFB1; LLGL1; YWHAG; TGFB2; ITGB2
Adherens junction
ACTG1; PTBP3; PTPRF; INSRA; NLK1; CSNK2A1; PVRL2; SNAI2; ACTN1; SSX2IP
Signaling pathways regulating pluripotency of stem cells
PIK3CG; MAP2K2; ACVR2A; WNT11; WNT10B; DLX5; PIK3CD; INHBE; INHBA; PIK3R3
Chagas disease (American trypanosomiasis)
C1QC; MAP2K4; IKBKG; GNAI1; C1QA; CCL3; IFNGR2; PIK3R5; IL1B; MAPK10
HTLV-I infection
DVL1; WNT11; BAX; PPP3CC; APC2; HLA-B; HLA-DPA1; WNT3A; Il2; PCNA
Pathways in cancer
TRAF5; Ar; MAPK9; HDAC1; PTCH1; PTEN; CCNE1; EGLN2; GNAI3; RUNX1
Proteoglycans in cancer
HPSE2; RPS6KB2; WNT3A; ERBB2; VEGFA; MTOR; WNT4; WNT10B; PDCD4; PIK3CA
Colorectal cancer
PIK3R1; CASP9; TGFB2; TRP53; PIK3CG; MSH2; AKT1; AXIN2; FOS; MAPK10
Pancreatic cancer
PIK3R3; TP53; TGFB2; TGFA; IKBKG; PIK3R5; TGFB3; CDC42; SMAD2; VEGFA
Inflammatory bowel disease (IBD)
IFNG; IL23; IL18R1; IL1A; Il23a; Il12b; TGFB1; IL2RG; HLA-DPB1; HLA-DPA1; IL21R

Protein Function

SMAD2 has several biochemical functions, for example, contributes_to DNA binding, I-SMAD binding, R-SMAD binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SMAD2 itself. We selected most functions SMAD2 had, and list some proteins which have the same functions with SMAD2. You can find most of the proteins on our site.
Function
Related Protein
Function contributes_to DNA binding
Related Protein GTF3C4; MAFGA; MAFGB; MRE11A; FOXH1; NFE2L2A; GTF3C3; TCF3; SMAD2; RFC3
Function I-SMAD binding
Related Protein SMAD6; SMAD1; SMAD2; SMURF1; CTNNB1; SMAD7; AXIN1; TGFB1I1; SMAD4; TGFBR1
Function R-SMAD binding
Related Protein FOS; PARP1; AXIN1; PMEPA1; PAX6; SMURF1; SMAD3; MEN1; RANBP3; ZC3H3
Function RNA polymerase II core promoter proximal region sequence-specific DNA binding
Related Protein NKX2; TBX15; MITFA; NFYC; RBPJA; MAFB; NFE2L3; SPI1; NPAS4; NKX3-2
Function SMAD binding
Related Protein BMPR1B; TOB1; PURB; FKBP1A; COL5A2; CTNNB1; DAB2; HIPK2; SKI; COL1A2
Function activating transcription factor binding
Related Protein HDAC1; PPARG; GATA4; PRDM16; SMAD2; RELA; HDAC4; EP300; MEF2A; PSIP1
Function chromatin binding
Related Protein ERCC6; APBB1; SOX15; SMC3; SETD7; ASH1L; ARID5A; ATOH1A; MCM5; HMGB3A
Function co-SMAD binding
Related Protein FOXH1; SMAD3; GATA4; SMAD2; SMAD6; TRIM33; SMAD1; CITED1; USP9X; TGIF1
Function double-stranded DNA binding
Related Protein RAD51L1; HMGB2; HMGB1; GTF2H4; MTERF2; TP73; IFI16; RAD51B; NTHL1; EGFR
Function enhancer binding
Related Protein MESP1; ELL3; TCF3; SMAD3; SP1; TCF12; ARNT; SMAD2; FOXH1; SOX9
Function metal ion binding
Related Protein ZBTB4; EGR1; HPDB; POLB; ZNF383; PC; ZNF215; KLF8; ZFP828; ZFP428
Function phosphatase binding
Related Protein DLG3; CSRNP2; CTSC; SPRED1; SLC9A3R1; SYTL2; SLC9A3R2; ELFN2; SH3YL1; SMAD2
Function protein binding
Related Protein SIRT7; CCL20; DDB2; PPP2CA; IFI6; VEGFB; CSDE1; RBM39; NAPB; OSTB
Function protein heterodimerization activity
Related Protein PPP2R1A; PRSS28; SLC51B; NPAS4; ALX4; TAS1R3; Fzd4; HNF1B; DRAP1; Pdgfa&Pdgfb
Function protein homodimerization activity
Related Protein DAPK3; IRF3; IL12B; NFS1; WHRN; ATPIF1A; FASN; GREM2; SLC51A; BST2
Function transcription factor activity, sequence-specific DNA binding
Related Protein SMAD6A; POU3F1; CREB1B; TCEAL1; CREBL2; FOXE3; GATAD2B; TBPL2; SPIB; TSC22D1
Function contributes_to transcription factor activity, sequence-specific DNA binding
Related Protein GATA4; FOXH1; RXRA; VDRA; SOX19A; SMAD2; SMAD3; SOX1B; MAFGB; HNRNPAB
Function transcription factor binding
Related Protein TRIB2; JUND; HES6; KEAP1B; PER1; FOSB; MDFI; SMARCD3; AHR; BPTF
Function transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
Related Protein MYOG; MIXL1; CREB3L1; AKNA; MYOCD; BCL11B; ELK3; MEIS1; ELF1; PHOX2B
Function transforming growth factor beta receptor binding
Related Protein TGFBRAP1; INHA; BMP10; INHBB; LFT2; INHBAB; GDF11; BMP7; MSTNB; SMAD2
Function transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity
Related Protein SMAD1; SMAD2; SMAD9; SMAD3
Function type I transforming growth factor beta receptor binding
Related Protein TGFB3; TGFBR2; FKBP1A; SMAD7; SMAD2; SMAD6; SNX25; ENG; TGFB1
Function ubiquitin protein ligase binding
Related Protein SUMO2; PRDX6; CDC34; SCAMP3; UBE2NB; MC1R; CBS; ATP6V0C; RNF31; CDC34B

Interacting Protein

SMAD2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SMAD2 here. Most of them are supplied by our site. Hope this information will be useful for your research of SMAD2.
SMAD4

SMAD2 Related Articles

Glenn, DJ; Cardema, MC; et al. Cardiac steatosis potentiates angiotensin II effects in the heart. AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY 308:H339-H350(2015).
Li, TT; Zhang, XH; et al. Artemisinin analogue SM934 ameliorates the proteinuria and renal fibrosis in rat experimental membranous nephropathy. ACTA PHARMACOLOGICA SINICA 36:188-199(2015).

SMAD2 Related Gene Family

TGF