smad2
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  • Official Full Name
  • SMAD family member 2
  • Background
  • SMAD2 or Mothers against decapentaplegic homolog 2 is a polypeptide that, as its name describes, is a homolog of the Drosophila gene: Mothers against decepentaplegic. It belongs to the SMAD family of proteins, which belong to the TGFbeta superfamily of modulators. Like many other TGFbeta family members SMAD2 is involved in cell signalling. SMAD2 modulates signals of activin and TGFbeta's. It interacts with SMAD anchor for receptor activation (SARA). The binding of ligands causes the phosphorylation of the SMAD2 protein and the dissociation from SARA and the association with SMAD4. It is subsequently transferred to the nucleus where it forms complexes with other proteins and acts as a transcription factor. SMAD2 is a receptor regulated SMAD (R-SMAD) and is activated by bone morphogenetic protein type 1 receptor kinase.
  • Synonyms
  • SMAD2; SMAD family member 2; MAD, mothers against decapentaplegic homolog 2 (Drosophila) , MADH2, SMAD, mothers against DPP homolog 2 (Drosophila); mothers against decapentaplegic homolog 2; JV18 1; MADR2; MAD homolog 2; mother against DPP homolog 2; Sma- and Mad-related protein 2; SMAD, mothers against DPP homolog 2; JV18; MADH2; JV18-1; hMAD-2; hSMAD2; MGC22139; MGC34440
Cat.#:SMAD2-1915HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human SMAD2 Protein, MYC/DDK-tagged
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Cat.#:SMAD2-306HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human SMAD2 Protein, His-tagged
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Cat.#:Smad2-307MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Smad2 Protein, His-tagged
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Cat.#:SMAD2-118HTag:T7/His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human SMAD2 protein, T7/His-tagged
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Cat.#:SMAD2-294HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human SMAD2 protein, GST-tagged
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Cat.#:SMAD2-30446THTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human SMAD2, His-tagged
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Cat.#:SMAD2-30447THTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human SMAD2
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Cat.#:SMAD2-324HTag:His/MBP
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human SMAD2 protein, His/MBP-tagged
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Cat.#:SMAD2-392HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human SMAD Family Member 2, His-tagged
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Cat.#:SMAD2-901MTag:GST/His
Source (Host):Baculovirus-Insect CellsSpecies:Mouse
Product nameRecombinant Mouse SMAD2 Protein, GST & His-tagged
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Cat.#:SMAD2-5607RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat SMAD2 Protein
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Cat.#:SMAD2-4330RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey SMAD2 Protein, His-tagged
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Cat.#:SMAD2-6130CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken SMAD2
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Cat.#:SMAD2-8420ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish SMAD2
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Cat.#:SMAD2-1093HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human SMAD Family Member 2, GST-tagged
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Cat.#:SMAD5-1096HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human SMAD Family Member 5, GST-tagged
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Cat.#:SMAD2-001MCLTag:
Source (Host):Baculovirus-Insect CellsSpecies:Mouse
Product nameRecombinant Mouse SMAD2 cell lysate
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Involved Pathway

SMAD2 involved in several pathways and played different roles in them. We selected most pathways SMAD2 participated on our site, such as FoxO signaling pathway, Cell cycle, Endocytosis, which may be useful for your reference. Also, other proteins which involved in the same pathway with SMAD2 were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
FoxO signaling pathway
PRKAB1B; IL7R; ATM; CDKN1BB; PIK3R2; GADD45BA; TGFB2; RAF1; MAP2K2A; PLK4
Cell cycle
CDKN1BB; STAG1; SMC4; SMAD3; GINS1; CCNB3; MYCA; YWHAQA; SPO11; TERF2
Endocytosis
KDRL; USP8; PARD6GB; WASH1; ARFGAP2; ARAP2; GRK7A; VPS37D; EHD2B; ARRB1
TGF-beta signaling pathway
ACVR2AA; BMP4; TGFB1; BMP7; THBS1; SMAD2; BMP5; CHD; ROCK1; RBX1
Hippo signaling pathway
SCRIB; TGFB1; FZD7; WTIP; BMP7; ID1; NF2; AJUBA; WNT2B; TCF7L2
Adherens junction
INSRB; CTNNA2; RHOAB; PVRL1B; FER; ACTB2; PTPRF; FGFR1A; INSR; FARP2
Signaling pathways regulating pluripotency of stem cells
TCF3; STAT3; WNT8B; HNF1A; INHBA; TBX3; SMAD2; MAPK11; NANOG; PIK3R1
Chagas disease (American trypanosomiasis)
CXCL8; IFNGR1; CD247; CD3E; CD3D; TLR4; ACE; PLCB3; IFNB1; CCL3L1; MAPK12
HTLV-I infection
RAN; SLC25A5; IKBKG; PIK3R1; PCNA; RELB; HLA-DOB; XPO1; CANX; SMAD3
Pathways in cancer
FGF20; PLCG1; MET; STK36; VEGFB; FGF8; MSH3; GNAI2; AKT1; CXCL12
Proteoglycans in cancer
SDC2; PIK3R5; WNT10B; WNT9B; MTOR; NANOG; KRAS; RRAS2; Ctsl; PPP1CA
Colorectal cancer
PIK3CA; PIK3R1; PIK3R5; MSH2; MAP2K1; MSH3; BIRC5; RAC3; PIK3R3; AKT1
Pancreatic cancer
MAPK8; BRCA2; PLD1; PIK3R1; RAF1; ARAF; RALGDS; ERBB2; TGFB1; TRP53
Inflammatory bowel disease (IBD)
IL12B; Il4ra; TGFB1; FOXP3; STAT3; IL17A; STAT4; HLA-DMA; Il2; IL12RB1

Protein Function

SMAD2 has several biochemical functions, for example, contributes_to DNA binding, I-SMAD binding, R-SMAD binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SMAD2 itself. We selected most functions SMAD2 had, and list some proteins which have the same functions with SMAD2. You can find most of the proteins on our site.
Function
Related Protein
Function contributes_to DNA binding
Related Protein MLXIPL; ARNTL1B; GTF3C3; NFE2L2A; FOXH1; GTF3C5; GTF3C4; AHR2; SMAD4; ARNTL1A
Function I-SMAD binding
Related Protein SMAD4; SMURF1; CTNNB1; TGFBR1; AXIN1; TGFB1I1; SMAD6; SMAD2; SMAD1; SMAD7
Function R-SMAD binding
Related Protein AXIN1; JUN; PMEPA1; MYOCD; FOS; SMAD4; ANKRD1; PARP1; ZEB2; ZC3H3
Function RNA polymerase II core promoter proximal region sequence-specific DNA binding
Related Protein NPAS4; Ar; HSF1; CEBPE; ETV4; GCFC2; CREB3L2; DPF2; RFX1; CDX4
Function SMAD binding
Related Protein AXIN1; USP15; SKIL; BMPR1A; SNW1; TCF12; CREBBP; SKOR1; MAGI2; ACVR1
Function activating transcription factor binding
Related Protein GATA4; RELA; PRDM16; HDAC4; TAF9; PSIP1; HDAC1; MEF2D; ATOH8; HDAC7A
Function chromatin binding
Related Protein PHF21B; PHF21A; Trl; ZKSCAN3; ERCC6; JMJD5; CCDC111; SKI; BAHCC1; HOXD10
Function co-SMAD binding
Related Protein SMAD2; USP9X; TGIF1; TRIM33; SMAD1; GATA4; FOXH1; SMAD6; CITED1; SMAD3
Function double-stranded DNA binding
Related Protein CGGBP1; MTERFD1; HNRNPDL; SATB1; AFF3; SP1; SP8B; RAD51AP1; GATA1A; DDX58
Function enhancer binding
Related Protein RAI1; SMAD3; AHR; LEF1; ELL3; ARNT; SP1; MESP1; SMAD2; TIPARP
Function metal ion binding
Related Protein ZNF831; CTH1; TDO2; MTMR3; CPS1; CYP2AA8; ZFP27; MAP3K3; GTPBP6; MORC2B
Function phosphatase binding
Related Protein ELFN2; DLG1; DYSFIP1; DZIP3; SPRED1; KIAA0649; MAGI2; TSC2; SH3GL1; MAST2
Function protein binding
Related Protein GRIA2; ZC3HC1; PML; NFKB1; ULK1; PRMT2; AMBP; ZDHHC17; DES; OGG1
Function protein heterodimerization activity
Related Protein PPP1CBL; GRIN1; VEGFB; BIK; JAM3; TGFB2; CENPA; SLC51A; BTBD11A; CLCN3
Function protein homodimerization activity
Related Protein IMPA1; HINT2; BMP4; S100A16; XPA; NDP; SLC26A5; ATPIF1; ERBB4; RAB11FIP4
Function transcription factor activity, sequence-specific DNA binding
Related Protein FLI1; ZNF323; ZNF445; RFX8; ZNF565; RARA; FOSL1A; ZNF573; ZIC2; PBX1
Function contributes_to transcription factor activity, sequence-specific DNA binding
Related Protein GATA4; SMAD2; VDR; NFE2L2A; FOXH1; TAF7; SMAD3; MAFGB; SOX1A; NKX2
Function transcription factor binding
Related Protein BCL2; NFATC2; CEBPA; NFATC4; SOST; ZBTB49; RBPJ; KEAP1B; TRIM6; THRA
Function transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
Related Protein TFAP2C; MEF2C; MYBL1; CEBPA; STK16; RFX4; POU3F2; NEUROD1; BCL11B; CRX
Function transforming growth factor beta receptor binding
Related Protein SMAD3; MSTNB; AMH; USP15; BMP2; FKBP1A; GDF6; NODAL; BMP2B; LEFTY1
Function transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity
Related Protein SMAD2; SMAD9; SMAD1; SMAD3
Function type I transforming growth factor beta receptor binding
Related Protein ENG; TGFB3; SMAD2; TGFB1; FKBP1A; SNX25; TGFBR2; SMAD6; SMAD7
Function ubiquitin protein ligase binding
Related Protein FZD8; UBE2KA; ATP6V0C; TRIB2; ARIH1; AURKA; TOLLIP; UBE2KB; EGR2; CDC34B

Interacting Protein

SMAD2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SMAD2 here. Most of them are supplied by our site. Hope this information will be useful for your research of SMAD2.
SMAD4

SMAD2 Related Articles

Glenn, DJ; Cardema, MC; et al. Cardiac steatosis potentiates angiotensin II effects in the heart. AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY 308:H339-H350(2015).
Li, TT; Zhang, XH; et al. Artemisinin analogue SM934 ameliorates the proteinuria and renal fibrosis in rat experimental membranous nephropathy. ACTA PHARMACOLOGICA SINICA 36:188-199(2015).

SMAD2 Related Gene Family

TGF