smad2
Share
  • Official Full Name
  • SMAD family member 2
  • Background
  • SMAD2 or Mothers against decapentaplegic homolog 2 is a polypeptide that, as its name describes, is a homolog of the Drosophila gene: Mothers against decepentaplegic. It belongs to the SMAD family of proteins, which belong to the TGFbeta superfamily of modulators. Like many other TGFbeta family members SMAD2 is involved in cell signalling. SMAD2 modulates signals of activin and TGFbeta's. It interacts with SMAD anchor for receptor activation (SARA). The binding of ligands causes the phosphorylation of the SMAD2 protein and the dissociation from SARA and the association with SMAD4. It is subsequently transferred to the nucleus where it forms complexes with other proteins and acts as a transcription factor. SMAD2 is a receptor regulated SMAD (R-SMAD) and is activated by bone morphogenetic protein type 1 receptor kinase.
  • Synonyms
  • SMAD2; SMAD family member 2; MAD, mothers against decapentaplegic homolog 2 (Drosophila) , MADH2, SMAD, mothers against DPP homolog 2 (Drosophila); mothers against decapentaplegic homolog 2; JV18 1; MADR2; MAD homolog 2; mother against DPP homolog 2; Sma- and Mad-related protein 2; SMAD, mothers against DPP homolog 2; JV18; MADH2; JV18-1; hMAD-2; hSMAD2; MGC22139; MGC34440
Cat.#:SMAD2-1915HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human SMAD2 Protein, MYC/DDK-tagged
+Inquiry
Cat.#:SMAD2-306HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human SMAD2 Protein, His-tagged
+Inquiry
Cat.#:Smad2-307MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Smad2 Protein, His-tagged
+Inquiry
Cat.#:SMAD2-118HTag:T7/His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human SMAD2 protein, T7/His-tagged
+Inquiry
Cat.#:SMAD2-294HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human SMAD2 protein, GST-tagged
+Inquiry
Cat.#:SMAD2-30446THTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human SMAD2, His-tagged
+Inquiry
Cat.#:SMAD2-30447THTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human SMAD2
+Inquiry
Cat.#:SMAD2-324HTag:His/MBP
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human SMAD2 protein, His/MBP-tagged
+Inquiry
Cat.#:SMAD2-392HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human SMAD Family Member 2, His-tagged
+Inquiry
Cat.#:SMAD2-901MTag:GST/His
Source (Host):Baculovirus-Insect CellsSpecies:Mouse
Product nameRecombinant Mouse SMAD2 Protein, GST & His-tagged
+Inquiry
Cat.#:SMAD2-5607RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat SMAD2 Protein
+Inquiry
Cat.#:SMAD2-4330RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey SMAD2 Protein, His-tagged
+Inquiry
Cat.#:SMAD2-6130CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken SMAD2
+Inquiry
Cat.#:SMAD2-8420ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish SMAD2
+Inquiry
Cat.#:SMAD2-1093HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human SMAD Family Member 2, GST-tagged
+Inquiry
Cat.#:SMAD5-1096HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human SMAD Family Member 5, GST-tagged
+Inquiry
Cat.#:SMAD2-001MCLTag:
Source (Host):Baculovirus-Insect CellsSpecies:Mouse
Product nameRecombinant Mouse SMAD2 cell lysate
+Inquiry

Involved Pathway

SMAD2 involved in several pathways and played different roles in them. We selected most pathways SMAD2 participated on our site, such as FoxO signaling pathway, Cell cycle, Endocytosis, which may be useful for your reference. Also, other proteins which involved in the same pathway with SMAD2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
FoxO signaling pathway
FASLG; EP300; MAP2K2B; G6PC2; SLC2A4; PIK3R3A; MAPK8A; MAPK12A; GABARAPL1; ATG12
Cell cycle
RUVBL2; CCNA1; MND1; SKA1; RBBP8; BUB3; TERF2; CLSPN; CDK11B; MCM9
Endocytosis
ARPC5A; HLA-C; SNX5; SMURF2; IL2RG; MVB12BA; FGFR2; SMAP1; RAB11FIP2; HLA-F
TGF-beta signaling pathway
NOG3; SPAW; BMP7A; THBS1; SMAD3A; SMAD1; BMP8B; AMH; ID3; RPS6KB1B
Hippo signaling pathway
PPP2CB; WNT10B; TGFBR2; FZD9; SERPINE1; NF2; GDF7; NKD1; PRKCZ; BMP7
Adherens junction
PTBP3; EP300; WASF2; NLK2; CTNNA1; MLLT4; CDH1; TGFBR1B; RHOA; ACP1
Signaling pathways regulating pluripotency of stem cells
BMI1; WNT2B; PCGF2; POU5F1; PCGF3; MAP2K2; ACVR1C; Fzd4; MAPK13; ID3
Chagas disease (American trypanosomiasis)
SMAD2; MAPK3; GNA11; AKT2; TNF; GNAO1; TLR9; TGFB2; PPP2R2C; LOC100033925
HTLV-I infection
PIK3CD; Fzd4; WNT10B; MAP3K3; TNFRSF13C; SLC25A5; WNT16; VDAC3; IL2RG; FOS
Pathways in cancer
HDAC1; NFKB2; EGLN3; AXIN2; DAPK1; FGF3; SPI1; FN1; APPL1; CSF3R
Proteoglycans in cancer
TLR4; PRKACA; LUM; PIK3CD; CAMK2D; WNT2; ANK1; NANOG; PTK2; PIK3CG
Colorectal cancer
AKT2; BCL2; SMAD2; RALGDS; MAP2K1; CYCS; MAPK1; RAC3; RAC1; PIK3CD
Pancreatic cancer
IKBKB; PIK3CA; AKT2; TGFBR2; TRP53; AKT1; MAP2K1; PIK3R1; CDC42; RAC3
Inflammatory bowel disease (IBD)
STAT4; HLA-DMB; HLA-DRB3; HLA-DPB1; TGFB3; IL21R; IL6; IL5; MAF; HLA-DRA

Protein Function

SMAD2 has several biochemical functions, for example, contributes_to DNA binding, I-SMAD binding, R-SMAD binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SMAD2 itself. We selected most functions SMAD2 had, and list some proteins which have the same functions with SMAD2. You can find most of the proteins on our site.
Function
Related Protein
Function contributes_to DNA binding
Related Protein GTF3C2; GTF3C5; CLOCKA; GTF3C4; MAFGA; TCF3; GTF3C3; MLXIPL; FOXH1; MAFGB
Function I-SMAD binding
Related Protein SMAD2; TGFB1I1; SMURF1; SMAD6; SMAD4; CTNNB1; SMAD1; AXIN1; TGFBR1; SMAD7
Function R-SMAD binding
Related Protein ZEB2; FOS; SMAD6; ANKRD1; JUN; FOXH1; PARP1; TRIM33; SMAD4; RANBP3
Function RNA polymerase II core promoter proximal region sequence-specific DNA binding
Related Protein ZNF100; ZNF695; MEOX1; GLI3; CRX; GMEB2; ELK3; CARF; NFKB2; GATA1
Function SMAD binding
Related Protein TGFBR3; PURA; SNW1; RNF111; TOB1; BMPR1A; SMURF2; YY1; FOXH1; EID2
Function activating transcription factor binding
Related Protein HDAC4; PSIP1; EEF1D; MEF2A; EP300; MEF2D; HDAC7; ATOH8; MEF2C; SMAD2
Function chromatin binding
Related Protein ZGLP1; APITD1; PHF8; SMARCE1; MEOX1; SVEP1; TLE1; NCOA1; SMC1A; HMGB2
Function co-SMAD binding
Related Protein SMAD1; USP9X; CITED1; SMAD6; TRIM33; SMAD2; FOXH1; SMAD3; TGIF1; GATA4
Function double-stranded DNA binding
Related Protein NTHL1; HMGB1; USF1; RAD51D; KLF6; ERCC5; DMC1; MEN1; GTF2H4; PIN4
Function enhancer binding
Related Protein ELL3; SMAD3; ARNT; RAI1; SP1; TIPARP; AHR; TCF12; SMAD2; FOXH1
Function metal ion binding
Related Protein CPSF3; ARHGEF1A; ZNF83; ATP2A2B; CYP2P6; RFPL4; SCRT1A; RFESD; ZSCAN21; ZFAND5A
Function phosphatase binding
Related Protein MAGI2; ELFN2; PPP1R26; SYTL2; CNST; PPP1R18; PPP1R32; PPARA; DZIP3; TSC2
Function protein binding
Related Protein CAPNS2; MOBKL2B; TMIGD2; TPX2; CD58; DCC; PDK3; DDX18; PAK4; MYBL2
Function protein heterodimerization activity
Related Protein YWHAE; APITD1; APOA2; TLR6; HNF1B; SOX32; BOK; CEBPB; HOMER1; BRAF
Function protein homodimerization activity
Related Protein HPGD; RAP1GAP; KCNK9; GRPEL2; ADRA2A; ABCB9; MCL1; NDP; GM5506; ANXA6
Function transcription factor activity, sequence-specific DNA binding
Related Protein DEAF1; ZNF615; SOX13; FOXP1B; ZBTB14; ZNF649; ZNF565; PHF5A; KDM1A; HLFB
Function contributes_to transcription factor activity, sequence-specific DNA binding
Related Protein SOX19B; TAF6; SMAD4; NKX2-5; SOX1A; RXRA; NKX2; SOX1B; TAF12; FOXH1
Function transcription factor binding
Related Protein NKX2; BCL3; MYBBP1A; CDKN2A; SP1; KAT6B; TLE1; CCND1; APBB1; FOXC1
Function transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
Related Protein MYBL2; KLF5; CAMTA2; PITX3; SFPI1; TFAM; SIX1; NOBOX; GATA2; CEBPB
Function transforming growth factor beta receptor binding
Related Protein MSTNB; BMP7B; BMP6; GDF9; SMURF2; INHBB; SMAD3; INHA; NODAL; GDF7
Function transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity
Related Protein SMAD3; SMAD2; SMAD9; SMAD1
Function type I transforming growth factor beta receptor binding
Related Protein SNX25; SMAD7; TGFB1; SMAD2; SMAD6; FKBP1A; TGFBR2; ENG; TGFB3
Function ubiquitin protein ligase binding
Related Protein RRAGA; BAG6; DNM1L; CUL3B; CUL3; GABARAPL1; HSPD1; UBE2G1A; BRCA1; TSG101

Interacting Protein

SMAD2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SMAD2 here. Most of them are supplied by our site. Hope this information will be useful for your research of SMAD2.
SMAD4

SMAD2 Related Articles

Glenn, DJ; Cardema, MC; et al. Cardiac steatosis potentiates angiotensin II effects in the heart. AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY 308:H339-H350(2015).
Li, TT; Zhang, XH; et al. Artemisinin analogue SM934 ameliorates the proteinuria and renal fibrosis in rat experimental membranous nephropathy. ACTA PHARMACOLOGICA SINICA 36:188-199(2015).

SMAD2 Related Gene Family

TGF