smad2
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  • Official Full Name
  • SMAD family member 2
  • Background
  • SMAD2 or Mothers against decapentaplegic homolog 2 is a polypeptide that, as its name describes, is a homolog of the Drosophila gene: Mothers against decepentaplegic. It belongs to the SMAD family of proteins, which belong to the TGFbeta superfamily of modulators. Like many other TGFbeta family members SMAD2 is involved in cell signalling. SMAD2 modulates signals of activin and TGFbeta's. It interacts with SMAD anchor for receptor activation (SARA). The binding of ligands causes the phosphorylation of the SMAD2 protein and the dissociation from SARA and the association with SMAD4. It is subsequently transferred to the nucleus where it forms complexes with other proteins and acts as a transcription factor. SMAD2 is a receptor regulated SMAD (R-SMAD) and is activated by bone morphogenetic protein type 1 receptor kinase.
  • Synonyms
  • SMAD2; SMAD family member 2; MAD, mothers against decapentaplegic homolog 2 (Drosophila) , MADH2, SMAD, mothers against DPP homolog 2 (Drosophila); mothers against decapentaplegic homolog 2; JV18 1; MADR2; MAD homolog 2; mother against DPP homolog 2; Sma- and Mad-related protein 2; SMAD, mothers against DPP homolog 2; JV18; MADH2; JV18-1; hMAD-2; hSMAD2; MGC22139; MGC34440
Cat.#:SMAD2-1915HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human SMAD2 Protein, MYC/DDK-tagged
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Cat.#:SMAD2-306HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human SMAD2 Protein, His-tagged
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Cat.#:Smad2-307MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Smad2 Protein, His-tagged
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Cat.#:SMAD2-118HTag:T7/His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human SMAD2 protein, T7/His-tagged
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Cat.#:SMAD2-294HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human SMAD2 protein, GST-tagged
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Cat.#:SMAD2-30446THTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human SMAD2, His-tagged
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Cat.#:SMAD2-30447THTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human SMAD2
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Cat.#:SMAD2-324HTag:His/MBP
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human SMAD2 protein, His/MBP-tagged
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Cat.#:SMAD2-392HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human SMAD Family Member 2, His-tagged
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Cat.#:SMAD2-901MTag:GST/His
Source (Host):Baculovirus-Insect CellsSpecies:Mouse
Product nameRecombinant Mouse SMAD2 Protein, GST & His-tagged
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Cat.#:SMAD2-5607RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat SMAD2 Protein
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Cat.#:SMAD2-4330RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey SMAD2 Protein, His-tagged
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Cat.#:SMAD2-6130CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken SMAD2
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Cat.#:SMAD2-8420ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish SMAD2
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Cat.#:SMAD2-1093HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human SMAD Family Member 2, GST-tagged
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Cat.#:SMAD5-1096HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human SMAD Family Member 5, GST-tagged
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Cat.#:SMAD2-001MCLTag:
Source (Host):Baculovirus-Insect CellsSpecies:Mouse
Product nameRecombinant Mouse SMAD2 cell lysate
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Involved Pathway

SMAD2 involved in several pathways and played different roles in them. We selected most pathways SMAD2 participated on our site, such as FoxO signaling pathway, Cell cycle, Endocytosis, which may be useful for your reference. Also, other proteins which involved in the same pathway with SMAD2 were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
FoxO signaling pathway
BNIP3; CAT; PLK3; CCNB1; FOXO1A; PTENB; AKT2; GRM1; HRASB; MAPK9
Cell cycle
SPC25; SMAD4; ANAPC5; OIP5; MIS18A; NIPBLA; FZR1; STIL; MAPRE1; E2F5
Endocytosis
VPS29; PLD2; SRC; RAB11B; PSD; ARAP2; SH3GL2; DNAJC6; ZFYVE9; CAV3
TGF-beta signaling pathway
TNF; FSTA; ROCK1; RPS6KB1B; BMPR1AA; TFDP1; SMAD9; BMPR1B; LEFTY2; SMAD7B
Hippo signaling pathway
AXIN2; WNT8A; LLGL2; PPP1CC; YWHAE; BMP7; FZD10; YAP1; TGFB1; TCF7
Adherens junction
PVRL4; CTNND1; WASF1; LMO7A; CDH1; CSNK2A2; ACTG1; TGFBR1A; CDC42L2; RAC2
Signaling pathways regulating pluripotency of stem cells
WNT7B; WNT7A; ID1; FGFR2; PIK3CA; IGF1; PIK3R3; ACVR1; AXIN2; NODAL
Chagas disease (American trypanosomiasis)
GNAI2; FAS; IL1B; CD247; PPP2R1A; IFNG; PIK3R1; CCL2; Il2; PLCB3
HTLV-I infection
CCND1; POLE3; TGFB1; SLC25A6; LTA; HLA-DPB1; WNT9A; FZD8; TRP53INP1; ANAPC4
Pathways in cancer
GNA11; GNG13; SMAD2; STAT5B; LAMA5; PIK3CG; TGFB2; RAC1; PIK3R2; MSH6
Proteoglycans in cancer
PRKACB; PAK1; TP53; PIK3CG; RPS6KB2; PPP1CC; CAMK2G; MAP2K2; WNT9A; MMP9
Colorectal cancer
AXIN2; LEF1; FOS; APPL1; BCL2; PIK3R2; GSK3B; TCF7; MAPK1; MAPK9
Pancreatic cancer
TP53; TGFBR2; RALB; PLD1; MAPK3; ARAF; NFKB1; RALBP1; VEGFA; RAD51
Inflammatory bowel disease (IBD)
RORA; HLA-DRB4; IL12RB1; HLA-DMB; FOXP3; HLA-DRA; IL18; TLR4; IL1B; IL21

Protein Function

SMAD2 has several biochemical functions, for example, contributes_to DNA binding, I-SMAD binding, R-SMAD binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SMAD2 itself. We selected most functions SMAD2 had, and list some proteins which have the same functions with SMAD2. You can find most of the proteins on our site.
Function
Related Protein
Function contributes_to DNA binding
Related Protein TCF3; AHR2; SMAD4; RFC3; CLOCKA; GTF3C6; MAFGA; MAFGB; MLXIPL; GTF3C4
Function I-SMAD binding
Related Protein AXIN1; SMAD6; CTNNB1; TGFBR1; AXIN2; SMAD4; SMAD7; SMAD2; SMAD1; SMURF1
Function R-SMAD binding
Related Protein AXIN1; SMURF1; PARP1; MEN1; ANKRD1; TRIM33; ZEB2; FOXH1; SMAD2; SMAD6
Function RNA polymerase II core promoter proximal region sequence-specific DNA binding
Related Protein MEF2A; DLX5; POU1F1; H2AFZ; ATF3; PYDC3; HNRNPK; ZFP746; ETV2; KCNIP3
Function SMAD binding
Related Protein CREBBP; ACVRL1; SKI; STUB1; TGFBR1; SKIB; PML; PURB; USP15; COL3A1
Function activating transcription factor binding
Related Protein EEF1D; DGKQ; ZFP516; HDAC4; RELA; PPARG; HDAC1; EP300; SMAD2; MEF2A
Function chromatin binding
Related Protein RELB; MBD1; NUPR1; SIX1; DLX3; ARID3C; CHAF1A; EBF2; ZGLP1; MSL1A
Function co-SMAD binding
Related Protein SMAD2; FOXH1; SMAD3; GATA4; SMAD1; TGIF1; USP9X; CITED1; SMAD6; TRIM33
Function double-stranded DNA binding
Related Protein CTNNB1; MRE11A; RAD51L3; APTX; YBX1; PIN4; SATB1; FBXO18; HNRPDL; TDG
Function enhancer binding
Related Protein ELL3; RAI1; MESP1; SMAD3; ARNT; SP1; FOXH1; SOX9; TCF12; SMAD2
Function metal ion binding
Related Protein B4GALT5; ZNF319; MORC1; DPEP3; ZNF200; RIMS1; PDE2A; ZNF763; ZFP335; ZBTB16A
Function phosphatase binding
Related Protein PPARA; SH3YL1; CARHSP1; SYTL2; KIAA0649; DLG1; CSRNP2; SH2D4A; MAPK1; PPP1R36
Function protein binding
Related Protein CEP350; EIF4A2; USP18; UBE2D3; OOEP; MAP4K5; ZNF16; QARS; PLCG1; HSPA13
Function protein heterodimerization activity
Related Protein BCL2A; ZHX3; BOKA; PPP2R1A; POU5F3; SRI; H2AFB2; BTBD11; PDSS1; PAFAH1B2
Function protein homodimerization activity
Related Protein HNF1B; TMEM192; UGT1A4; PLEKHB1; UGT1A7; NPPC; CBX5; CSF1R; SLC11A1; UNC13A
Function transcription factor activity, sequence-specific DNA binding
Related Protein ALS2CR8; ELF3; ZNF189; PRDM15; ARNT2; T; PBX4; ZNF606; SNAPC4; ZFP184
Function contributes_to transcription factor activity, sequence-specific DNA binding
Related Protein GATA4; SOX19A; TRIM28; VDR; TAF6; HNRNPAB; RXRA; MAFGB; VDRA; SOX19B
Function transcription factor binding
Related Protein HDAC1; HES4; TNFRSF10A; GATA4; DIP2B; DACT2; HMGB2; MED12; EGR1; FHL2
Function transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
Related Protein CEBPG; CEBPB; HEYL; EBF1; RELA; FOSL1; NRL; NFIC; SMAD2; CEBPZ
Function transforming growth factor beta receptor binding
Related Protein SMAD2; GDF6; MSTNA; INHBE; FKBP1A; GDF9; LEFTY2; AMH; BMP8B; TGFB1A
Function transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity
Related Protein SMAD2; SMAD9; SMAD3; SMAD1
Function type I transforming growth factor beta receptor binding
Related Protein SMAD7; FKBP1A; SMAD2; TGFBR2; TGFB1; SNX25; ENG; TGFB3; SMAD6
Function ubiquitin protein ligase binding
Related Protein SKI; DBT; LTBR; SCAMP3; UBE2Z; MC4R; BCL10; UBE2A; CCT2; RBX1

Interacting Protein

SMAD2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SMAD2 here. Most of them are supplied by our site. Hope this information will be useful for your research of SMAD2.
SMAD4

SMAD2 Related Articles

Glenn, DJ; Cardema, MC; et al. Cardiac steatosis potentiates angiotensin II effects in the heart. AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY 308:H339-H350(2015).
Li, TT; Zhang, XH; et al. Artemisinin analogue SM934 ameliorates the proteinuria and renal fibrosis in rat experimental membranous nephropathy. ACTA PHARMACOLOGICA SINICA 36:188-199(2015).

SMAD2 Related Gene Family

TGF