smad2
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  • Official Full Name
  • SMAD family member 2
  • Background
  • SMAD2 or Mothers against decapentaplegic homolog 2 is a polypeptide that, as its name describes, is a homolog of the Drosophila gene: Mothers against decepentaplegic. It belongs to the SMAD family of proteins, which belong to the TGFbeta superfamily of modulators. Like many other TGFbeta family members SMAD2 is involved in cell signalling. SMAD2 modulates signals of activin and TGFbeta's. It interacts with SMAD anchor for receptor activation (SARA). The binding of ligands causes the phosphorylation of the SMAD2 protein and the dissociation from SARA and the association with SMAD4. It is subsequently transferred to the nucleus where it forms complexes with other proteins and acts as a transcription factor. SMAD2 is a receptor regulated SMAD (R-SMAD) and is activated by bone morphogenetic protein type 1 receptor kinase.
  • Synonyms
  • SMAD2; SMAD family member 2; MAD, mothers against decapentaplegic homolog 2 (Drosophila) , MADH2, SMAD, mothers against DPP homolog 2 (Drosophila); mothers against decapentaplegic homolog 2; JV18 1; MADR2; MAD homolog 2; mother against DPP homolog 2; Sma- and Mad-related protein 2; SMAD, mothers against DPP homolog 2; JV18; MADH2; JV18-1; hMAD-2; hSMAD2; MGC22139; MGC34440
Cat.#:SMAD2-1915HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human SMAD2 Protein, MYC/DDK-tagged
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Cat.#:SMAD2-306HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human SMAD2 Protein, His-tagged
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Cat.#:Smad2-307MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Smad2 Protein, His-tagged
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Cat.#:SMAD2-118HTag:T7/His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human SMAD2 protein, T7/His-tagged
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Cat.#:SMAD2-294HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human SMAD2 protein, GST-tagged
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Cat.#:SMAD2-30446THTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human SMAD2, His-tagged
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Cat.#:SMAD2-30447THTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human SMAD2
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Cat.#:SMAD2-324HTag:His/MBP
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human SMAD2 protein, His/MBP-tagged
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Cat.#:SMAD2-392HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human SMAD Family Member 2, His-tagged
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Cat.#:SMAD2-901MTag:GST/His
Source (Host):Baculovirus-Insect CellsSpecies:Mouse
Product nameRecombinant Mouse SMAD2 Protein, GST & His-tagged
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Cat.#:SMAD2-5607RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat SMAD2 Protein
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Cat.#:SMAD2-4330RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey SMAD2 Protein, His-tagged
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Cat.#:SMAD2-6130CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken SMAD2
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Cat.#:SMAD2-8420ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish SMAD2
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Cat.#:SMAD2-1093HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human SMAD Family Member 2, GST-tagged
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Cat.#:SMAD5-1096HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human SMAD Family Member 5, GST-tagged
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Cat.#:SMAD2-001MCLTag:
Source (Host):Baculovirus-Insect CellsSpecies:Mouse
Product nameRecombinant Mouse SMAD2 cell lysate
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Involved Pathway

SMAD2 involved in several pathways and played different roles in them. We selected most pathways SMAD2 participated on our site, such as FoxO signaling pathway, Cell cycle, Endocytosis, which may be useful for your reference. Also, other proteins which involved in the same pathway with SMAD2 were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
FoxO signaling pathway
SMAD4; TGFB1; TGFBR1B; CAT; GABARAPA; MAPK14A; PLK1; MAPK11; EGFRA; PRKAG3
Cell cycle
RBBP7; CNEP1R1; GADD45AA; CCNA1; MCM3L; FAM175A; DULLARD; GSK3B; CLASP1; CDC14A
Endocytosis
TGFBR1A; CHMP3; ARF6; VPS36; RAB31; FAM125B; AP2M1B; DNM2; ARRB2B; BIN1B
TGF-beta signaling pathway
SPAW; TFDP1; INHBAB; PITX2; SMAD7; IFNG1-2; PPP2R1A; SMAD2; TGFBR2; TFDP1A
Hippo signaling pathway
WNT10B; BMP4; TGFBR2; PPP2R2C; PPP2R1A; WNT5A; WNT9A; MOBKL1A; CRB2; GLI2
Adherens junction
TCF7L1A; CDC42L; TGFBR1; EGFR; WASB; MLLT4; MAPK1; TCF7L2; SMAD3; ACTG1
Signaling pathways regulating pluripotency of stem cells
LIF; PIK3CA; IGF1R; ESX1; WNT8B; BMP4; FGFR3; PIK3CB; BMP2; SMARCAD1
Chagas disease (American trypanosomiasis)
IRAK4; TGFB2; CD3E; CD3D; TICAM1; TRAF6; PIK3R2; IL10; Il2; C1QA; TNF
HTLV-I infection
PDGFA; HLA-DRB5; MAP3K3; RAN; HRAS; POLE; XBP1; PTTG1; CDC27; SMAD2
Pathways in cancer
PPARG; BDKRB2; GNB2; EGLN2; GNAI3; LPAR3; PLEKHG5; COL4A1; Fgf15; GNG7
Proteoglycans in cancer
THBS1; NANOG; WNT2B; GPC3; HRAS; HPSE; PIK3R2; WNT10B; PIK3CB; HSPG2
Colorectal cancer
CYCS; DCC; MAPK3; APC; MAPK1; SMAD3; TGFB2; BCL2; BAD; MAPK8
Pancreatic cancer
RAD51; SMAD2; KRAS; PIK3CA; IKBKG; RAC1; BRCA2; RALB; TGFB2; STAT1
Inflammatory bowel disease (IBD)
IL12A; IL23R; SMAD2; IL12B; TNF; IL2RG; TGFB2; FOXP3; GATA3; IFNG

Protein Function

SMAD2 has several biochemical functions, for example, contributes_to DNA binding, I-SMAD binding, R-SMAD binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SMAD2 itself. We selected most functions SMAD2 had, and list some proteins which have the same functions with SMAD2. You can find most of the proteins on our site.
Function
Related Protein
Function contributes_to DNA binding
Related Protein GTF3C2; NFE2L2A; MAFGA; GTF3C6; ARNTL1A; RFC3; ARNTL1B; GTF3C3; GTF3C4; MAFGB
Function I-SMAD binding
Related Protein TGFB1I1; SMURF1; AXIN2; CTNNB1; TGFBR1; SMAD2; SMAD4; AXIN1; SMAD6; SMAD7
Function R-SMAD binding
Related Protein SMAD3; PPM1A; TRIM33; JUN; ZC3H3; SMAD2; PAX6; FOS; PARP1; C18orf1
Function RNA polymerase II core promoter proximal region sequence-specific DNA binding
Related Protein GCFC2; Ar; ELK1; SMAD6; MAFA; NKX2-8; H2AFZ; NFAT5; SKIL; HOXD13
Function SMAD binding
Related Protein SKOR1A; MAGI2; TGFBR3; CTNNB1; COL1A2; BMPR1B; COL5A2; SKIL; SKOR1; TGFBRAP1
Function activating transcription factor binding
Related Protein ATOH8; GATA4; ZFP516; MEF2C; HDAC4; PPARG; DGKQ; MEF2D; EP300; SMAD2
Function chromatin binding
Related Protein CBX1; NSD1; NFATC3; OVOL2; BRD3; UBE2T; NCAPD2; POLR2B; TTC5; SLC30A9
Function co-SMAD binding
Related Protein TGIF1; CITED1; SMAD1; SMAD6; USP9X; SMAD3; GATA4; TRIM33; FOXH1; SMAD2
Function double-stranded DNA binding
Related Protein IFI16; HMGB3; KLF6; HNRNPDL; TEF; HNRPDL; FEN1; RAD51L1; XRCC5; ZNF638
Function enhancer binding
Related Protein SMAD2; MESP1; ELL3; SOX9; LEF1; TCF3; SP1; TIPARP; FOXH1; ARNT
Function metal ion binding
Related Protein LATS2; ZFP704; KLF11; PPP6C; ADH8B; ASAP2A; ZNF396; ZNF705B; ADNP2A; RBM4B
Function phosphatase binding
Related Protein PPP1R18; CHCHD3; ELL; PPP1R35; KIAA0649; DLG1; CARHSP1; SH3GL1; TPRN; PPP1R32
Function protein binding
Related Protein ZMYND10; TIGIT; ASMTL; DOK3; LINC01588; RFESD; DNAJC28; DPYSL3; KLC4; CCDC130
Function protein heterodimerization activity
Related Protein ERBB2; SCGB2A1; UGT1A9; CYBB; HOMER2; BCL2L1; SMAD1; PPP2R1A; HIST1H4L; H2AFVA
Function protein homodimerization activity
Related Protein TNNC1; BARD1; RNF40; UGT1A7; MAP3K12; DMRT1; RAG1; PVRL3; TCF3A; NADK2
Function transcription factor activity, sequence-specific DNA binding
Related Protein BHLHE40; ZFP42; RAB11FIP4A; SOX4; LHX1; ZFP12; SOX2; ZFP161; ATOH1; STAT3
Function contributes_to transcription factor activity, sequence-specific DNA binding
Related Protein MAFGA; GATA4; NKX2; VDRB; SMAD2; VDRA; MAFGB; TAF7; SOX19A; SOX1B
Function transcription factor binding
Related Protein MAPK9; CEBPG; NLK; MED12; TRERF1; HDAC4; E2F2; IFT172; KCTD1; FIGLA
Function transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
Related Protein GATA3; CTCFL; POU2F2; NR3C1; AKNA; KLF4; TTC6; ARNT2; SMAD4; ONECUT2
Function transforming growth factor beta receptor binding
Related Protein BMP3; INHBAB; BMP4; LEFTY1; GDF15; GDF10; INHBAA; SMAD3; INHBE; BMP2
Function transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity
Related Protein SMAD3; SMAD9; SMAD2; SMAD1
Function type I transforming growth factor beta receptor binding
Related Protein FKBP1A; TGFB3; TGFB1; SMAD7; TGFBR2; SMAD2; SMAD6; SNX25; ENG
Function ubiquitin protein ligase binding
Related Protein HERC2; RNF34; USP2; YWHAZ; FAF2; STX8; AKTIP; PRDX6; PRR5L; HSPA8

Interacting Protein

SMAD2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SMAD2 here. Most of them are supplied by our site. Hope this information will be useful for your research of SMAD2.
SMAD4

SMAD2 Related Articles

Glenn, DJ; Cardema, MC; et al. Cardiac steatosis potentiates angiotensin II effects in the heart. AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY 308:H339-H350(2015).
Li, TT; Zhang, XH; et al. Artemisinin analogue SM934 ameliorates the proteinuria and renal fibrosis in rat experimental membranous nephropathy. ACTA PHARMACOLOGICA SINICA 36:188-199(2015).

SMAD2 Related Gene Family

TGF