sp100
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  • Official Full Name
  • SP100 nuclear antigen
  • Background
  • This gene encodes a subnuclear organelle and major component of the PML (promyelocytic leukemia)-SP100 nuclear bodies. PML and SP100 are covalently modified by the SUMO-1 modifier, which is considered crucial to nuclear body interactions. The encoded protein binds heterochromatin proteins and is thought to play a role in tumorigenesis, immunity, and gene regulation. Alternatively spliced variants have been identified for this gene; one of which encodes a high-mobility group protein. [provided by RefSeq, Aug 2011]
  • Synonyms
  • SP100; SP100 nuclear antigen; lysp100b; nuclear autoantigen Sp-100; speckled 100 kDa; SP100-HMG nuclear autoantigen; nuclear dot-associated Sp100 protein;
Cat.#:SP100-201HTag:GST
Source (Host):E.coliSpecies:Human
Product nameRecombinant Human SP100 Protein, GST-tagged
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Cat.#:SP100-202HTag:His
Source (Host):E.coliSpecies:Human
Product nameRecombinant Human SP100 Protein, His-tagged
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Cat.#:SP100-30988THTag:
Source (Host):Wheat germSpecies:Human
Product nameRecombinant Human SP100
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Cat.#:SP100-30989THTag:
Source (Host):Wheat germSpecies:Human
Product nameRecombinant Human SP100
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Cat.#:SP100-462HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human SP100 Protein, His-tagged
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Cat.#:Sp100-463MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Sp100 Protein, His-tagged
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Cat.#:Sp100-464RTag:His
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Sp100 Protein, His-tagged
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Cat.#:SP100-1674HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human SP100 cell lysate
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Involved Pathway

SP100 involved in several pathways and played different roles in them. We selected most pathways SP100 participated on our site, such as Herpes simplex infection, Viral carcinogenesis, which may be useful for your reference. Also, other proteins which involved in the same pathway with SP100 were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Herpes simplex infection
IFIT1; TNFRSF1A; SFRS3B; TRAF5; IFNA1; MHC2DAB; HCFC1; ARNTL1A; MHC1UEA; PML
Viral carcinogenesis
NFKB2; YWHAH; TP53; PMAIP1; HDAC9; GTF2E2; RHOA; HIST2H2BB; PIK3R1; TRADD

Protein Function

SP100 has several biochemical functions, for example, DNA binding, chromatin binding, chromo shadow domain binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SP100 itself. We selected most functions SP100 had, and list some proteins which have the same functions with SP100. You can find most of the proteins on our site.
Function
Related Protein
Function DNA binding
Related Protein ZFP771; PPARD; DOT1L; ZFAND5B; YBX1; TBX16; TBX22; HP1BP3; IFT57; THAP11
Function chromatin binding
Related Protein HDAC5; LRWD1; RAN; POU2F1; NCOA2; SMARCA2; TOX3; MCM5; KIAA0101; RDBP
Function chromo shadow domain binding
Related Protein LBR; SP100; NIPBL; CHAF1A; ATRX; TRIM28
Function cytokine activity
Related Protein NRG1; VSTM1; CSF1A; TNFSF9; FASLG; GDF5; Ccl27a; PRL7D1; BMP6; IL6
Function identical protein binding
Related Protein KHDC1A; BRI3; TK1; CD28; CALHM1; TNPO3; GOT1L1; GUCY2E; DHX8; WRNIP1
Function kinase binding
Related Protein PPP1R9B; STRADA; DGKQ; TRADD; SLC2A1; JAKMIP2; PPP2R5A; PRKAA1; GFAP; PER1
Function protein binding
Related Protein HMG20B; NFYC; PPFIA1; RPL19; LRFN4; NT5C3B; TEKT1; GPSM3; PLSCR3; WASH1
Function protein domain specific binding
Related Protein CHMP1B; TRIM11; POU2F2; EHD2; MECP2; CNTLN; GNAI3; WNT3; PPP3R1; TACC2
Function protein homodimerization activity
Related Protein ERCC5; HSP90AA1; CCDC103; FLT3LG; SLC30A8; SDCBP2; MYOM1; DMRT1; GRPEL1; TCF4
Function transcription coactivator activity
Related Protein BIRC2; CTNNB1; MED23; NFKB2; TAF1; NCOA1; SMARCB1; CALCOCO1; TAF7; MTDH
Function transcription corepressor activity
Related Protein TFAP2B; AEBP1; NPAT; BHLHE40; NAB2; DR1; NR0B1; MXI1; LDB1; HDAC9
Function transcription factor binding
Related Protein GPX3; MDFI; SMARCA4; NR0B1; THRA; EPN1; E2F2; PPID; HES3; KEAP1B

Interacting Protein

SP100 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SP100 here. Most of them are supplied by our site. Hope this information will be useful for your research of SP100.
SUMO1; UL123; CASP8AP2; ACTN2

SP100 Related Articles

Norman, GL; Yang, CY; et al. Anti-kelch-like 12 and anti-hexokinase 1: novel autoantibodies in primary biliary cirrhosis. LIVER INTERNATIONAL 35:642-651(2015).
Villalta, D; Sorrentino, MC; et al. Autoantibody profiling of patients with primary biliary cirrhosis using a multiplexed line-blot assay. CLINICA CHIMICA ACTA 438:135-138(2015).