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Official Full Name SP100 nuclear antigen
Background This gene encodes a subnuclear organelle and major component of the PML (promyelocytic leukemia)-SP100 nuclear bodies. PML and SP100 are covalently modified by the SUMO-1 modifier, which is considered crucial to nuclear body interactions. The encoded protein binds heterochromatin proteins and is thought to play a role in tumorigenesis, immunity, and gene regulation. Alternatively spliced variants have been identified for this gene; one of which encodes a high-mobility group protein. [provided by RefSeq, Aug 2011]
Synonyms SP100; SP100 nuclear antigen; lysp100b; nuclear autoantigen Sp-100; speckled 100 kDa; SP100-HMG nuclear autoantigen; nuclear dot-associated Sp100 protein;
    • Species :
    • Human
    • Mouse
    • Rat
    • Source :
    • E.coli
    • Wheat Germ
    • Tag :
    • GST
    • His
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human SP100-1674HCL Recombinant Human SP100 cell lysate N/A
    Human SP100-201H Recombinant Human SP100 Protein, GST-tagged E.coli GST
    Human SP100-202H Recombinant Human SP100 Protein, His-tagged E.coli His
    Human SP100-30988TH Recombinant Human SP100 Wheat Germ N/A
    Human SP100-30989TH Recombinant Human SP100 Wheat Germ N/A
    Human SP100-462H Recombinant Human SP100 Protein, His-tagged E.coli His
    Mouse Sp100-463M Recombinant Mouse Sp100 Protein, His-tagged E.coli His
    Rat Sp100-464R Recombinant Rat Sp100 Protein, His-tagged E.coli His

    SP100 involved in several pathways and played different roles in them. We selected most pathways SP100 participated on our site, such as Herpes simplex infection, Viral carcinogenesis, which may be useful for your reference. Also, other proteins which involved in the same pathway with SP100 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Herpes simplex infection TAP2; IRF9; BLB1; IKBKE; MHC2DCB; C3; CLOCK; HLA-DRB1; HLA-DRA; HMGN1
    Viral carcinogenesis HIST1H2BH; HIST1H4L; NFKB1; YWHAZ; TRAF3; HIST1H4M; HIST1H2BO; PKM2; VDAC3; GTF2B

    SP100 has several biochemical functions, for example, DNA binding, chromatin binding, chromo shadow domain binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SP100 itself. We selected most functions SP100 had, and list some proteins which have the same functions with SP100. You can find most of the proteins on our site.

    Function Related Protein
    DNA binding APEX2; ZNF45; ZEB2; CLSPN; ZNF19; POLR2B; HOXC3A; CRSP7; CXXC4; ZFY1
    chromatin binding FABP1; BRD2; ING5; NKX2; MB21D2; CDK9; RING1; EWSR1A; GLI3; Ar
    chromo shadow domain binding LBR; TRIM28; CHAF1A; ATRX; SP100; NIPBL
    cytokine activity CSF2; IFNA10; LTB; NDR2; CMTM1; WNT5A; IL11; IL22; MSTNB; CMTM5
    identical protein binding FGFR1; HSPB8; DPY30; NELL2; RABAC1; PPPDE2; EPOR; TLR3; CLDN20; ITGA2B
    kinase binding PIP5K1A; CHP1; MIDN; PFKL; PPP1R9B; JAKMIP1; SGOL1; UBQLN1; WWC2; CAB39
    protein binding ARRB1; PABPC4; PLLP; SOCS7; C18orf56; DNAJB11; FAS; MYO5A; ESRP1; PHC3
    protein domain specific binding TACC2; SLC34A2; STXBP1; COX4I2; CALM3; AKAP5; RAN; CHMP2B; PRKCZ; HIST2H4A
    protein homodimerization activity ADSSL1; ADD2; SETMAR; NR4A3; APOBEC3G; PDGFRA; LGALS6; NACC2; HSPB6; Il6ra
    transcription coactivator activity YY1; SRA1; LPIN2; SCAND1; MED16; HSF2; GTF2F1; GRIP1; MYOD1; NR2F1
    transcription corepressor activity HDAC7A; FEV; CTBP2A; NCOR2; SKIL; SKOR1B; PPP1R13L; TLE2; HOMEZ; ATF5
    transcription factor binding Ar; PPP1R13BB; TCF7L2; EPN1; HOXA7; HEY2; ATG7; HDAC8; APBB2; PIAS2

    SP100 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SP100 here. Most of them are supplied by our site. Hope this information will be useful for your research of SP100.

    SUMO1; UL123; CASP8AP2; ACTN2

    Norman, GL; Yang, CY; et al. Anti-kelch-like 12 and anti-hexokinase 1: novel autoantibodies in primary biliary cirrhosis. LIVER INTERNATIONAL 35:642-651(2015).
    Villalta, D; Sorrentino, MC; et al. Autoantibody profiling of patients with primary biliary cirrhosis using a multiplexed line-blot assay. CLINICA CHIMICA ACTA 438:135-138(2015).

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