SP100
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Official Full Name
SP100 nuclear antigen -
Overview
This gene encodes a subnuclear organelle and major component of the PML (promyelocytic leukemia)-SP100 nuclear bodies. PML and SP100 are covalently modified by the SUMO-1 modifier, which is considered crucial to nuclear body interactions. The encoded protein binds heterochromatin proteins and is thought to play a role in tumorigenesis, immunity, and gene regulation. Alternatively spliced variants have been identified for this gene; one of which encodes a high-mobility group protein. [provided by RefSeq, Aug 2011] -
Synonyms
SP100;SP100 nuclear antigen;lysp100b;nuclear autoantigen Sp-100;speckled 100 kDa;SP100-HMG nuclear autoantigen;nuclear dot-associated Sp100 protein
Recombinant Proteins
- Human
- Mouse
- Rat
- E.coli
- Wheat Germ
- In Vitro Cell Free System
- GST
- His
- Non
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| SP100-201H | Recombinant Human SP100 Protein, GST-tagged | E.coli | Human | GST | 700-876 |
|
| SP100-202H | Recombinant Human SP100 Protein, His-tagged | E.coli | Human | His | 700-876 |
|
| SP100-30988TH | Recombinant Human SP100 | Wheat Germ | Human | Non | 480 amino acids |
|
| SP100-30989TH | Recombinant Human SP100 | Wheat Germ | Human | Non | 98 amino acids |
|
| SP100-462H | Recombinant Human SP100 Protein, His-tagged | E.coli | Human | His | Gly610~Lys802 |
|
| Sp100-463M | Recombinant Mouse Sp100 Protein, His-tagged | E.coli | Mouse | His | Thr261~Lys465 |
|
| Sp100-464R | Recombinant Rat Sp100 Protein, His-tagged | E.coli | Rat | His | Phe116~Pro333 |
|
| SP100-1674HCL | Recombinant Human SP100 cell lysate | Human | Non |
|
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| SP100-488HF | Recombinant Full Length Human SP100 Protein | In Vitro Cell Free System | Human | Full L. 480 amino acids |
|
Involved Pathway
SP100 involved in several pathways and played different roles in them. We selected most pathways SP100 participated on our site, such as Herpes simplex infection,Viral carcinogenesis, which may be useful for your reference. Also, other proteins which involved in the same pathway with SP100 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Viral carcinogenesis | YWHAG,SCIN,IRF7,SND1,HIST1H4F,ACTN3,NFKB2,GSN,HIST2H2BE,CCND2 |
| Herpes simplex infection | CLOCKB,IFNA8,Ifna11,CSNK2A2A,CDC34A,ALYREF,USP7,EIF2AK3,EEF1DB,EIF2AK1 |
Protein Function
SP100 has several biochemical functions, for example, DNA binding,chromatin binding,chromo shadow domain binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SP100 itself. We selected most functions SP100 had, and list some proteins which have the same functions with SP100. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| identical protein binding | HAPLN2,CASC3,DYNLT3,AMOTL2,MRAP2,SH3GL2,TFRC,TRAF2,TOPBP1,BNIP3 |
| protein homodimerization activity | CCL5,TREX2,HOGA1,VEGFB,APOBEC3G,NOS1,HNF1B,FASN,SNX6,NLRC4 |
| cytokine activity | CSF1A,HMGB1B,TNFSF10,IFNA14,WNT1,Il23a; Il12b,TGFB3,LFT1,Il1f6,TNFSF14 |
| chromo shadow domain binding | NIPBL,TRIM28,LBR,CHAF1A,ATRX |
| DNA binding | TFDP1,CLOCK,MTF1,CLSPN,ZFP579,ASXL1,MSH4,PSMC3IP,RPS15,EZH2 |
| protein binding | HIST1H2BB,TIMM8A,ELAVL2,TRAF3IP2,SERTAD1,RPUSD3,CATSPERG2,SENP1,JUN,TEN1 |
| kinase binding | PER1,PARK2,PRPSAP1,DLG4,LDHA,MIDN,EMP2,PTPN22,MOB4,RASGRP3 |
| transcription factor binding | IFT172,MSX2,MAFB,TRIM6,GTF2A2,SUMO1,CXXC5,ZEB1,NFATC3,CCND1 |
| transcription corepressor activity | IRF2BP2,LHX9,BCOR,SSX4,NRIP1,CBX4,HSBP1,PIAS1,AEBP1,FEV |
Interacting Protein
SP100 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SP100 here. Most of them are supplied by our site. Hope this information will be useful for your research of SP100.
SUMO1;UL123;CASP8AP2;ACTN2
Resources
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References
- Norman, GL; Yang, CY; et al. Anti-kelch-like 12 and anti-hexokinase 1: novel autoantibodies in primary biliary cirrhosis. LIVER INTERNATIONAL 35:642-651(2015).
- Villalta, D; Sorrentino, MC; et al. Autoantibody profiling of patients with primary biliary cirrhosis using a multiplexed line-blot assay. CLINICA CHIMICA ACTA 438:135-138(2015).
