| Official Full Name | SP100 nuclear antigen |
| Background | This gene encodes a subnuclear organelle and major component of the PML (promyelocytic leukemia)-SP100 nuclear bodies. PML and SP100 are covalently modified by the SUMO-1 modifier, which is considered crucial to nuclear body interactions. The encoded protein binds heterochromatin proteins and is thought to play a role in tumorigenesis, immunity, and gene regulation. Alternatively spliced variants have been identified for this gene; one of which encodes a high-mobility group protein. [provided by RefSeq, Aug 2011] |
| Synonyms | SP100; SP100 nuclear antigen; lysp100b; nuclear autoantigen Sp-100; speckled 100 kDa; SP100-HMG nuclear autoantigen; nuclear dot-associated Sp100 protein; |
| Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
|---|
SP100 involved in several pathways and played different roles in them. We selected most pathways SP100 participated on our site, such as Herpes simplex infection, Viral carcinogenesis, which may be useful for your reference. Also, other proteins which involved in the same pathway with SP100 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Herpes simplex infection | TAP2; IRF9; BLB1; IKBKE; MHC2DCB; C3; CLOCK; HLA-DRB1; HLA-DRA; HMGN1 |
| Viral carcinogenesis | HIST1H2BH; HIST1H4L; NFKB1; YWHAZ; TRAF3; HIST1H4M; HIST1H2BO; PKM2; VDAC3; GTF2B |
SP100 has several biochemical functions, for example, DNA binding, chromatin binding, chromo shadow domain binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SP100 itself. We selected most functions SP100 had, and list some proteins which have the same functions with SP100. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| DNA binding | APEX2; ZNF45; ZEB2; CLSPN; ZNF19; POLR2B; HOXC3A; CRSP7; CXXC4; ZFY1 |
| chromatin binding | FABP1; BRD2; ING5; NKX2; MB21D2; CDK9; RING1; EWSR1A; GLI3; Ar |
| chromo shadow domain binding | LBR; TRIM28; CHAF1A; ATRX; SP100; NIPBL |
| cytokine activity | CSF2; IFNA10; LTB; NDR2; CMTM1; WNT5A; IL11; IL22; MSTNB; CMTM5 |
| identical protein binding | FGFR1; HSPB8; DPY30; NELL2; RABAC1; PPPDE2; EPOR; TLR3; CLDN20; ITGA2B |
| kinase binding | PIP5K1A; CHP1; MIDN; PFKL; PPP1R9B; JAKMIP1; SGOL1; UBQLN1; WWC2; CAB39 |
| protein binding | ARRB1; PABPC4; PLLP; SOCS7; C18orf56; DNAJB11; FAS; MYO5A; ESRP1; PHC3 |
| protein domain specific binding | TACC2; SLC34A2; STXBP1; COX4I2; CALM3; AKAP5; RAN; CHMP2B; PRKCZ; HIST2H4A |
| protein homodimerization activity | ADSSL1; ADD2; SETMAR; NR4A3; APOBEC3G; PDGFRA; LGALS6; NACC2; HSPB6; Il6ra |
| transcription coactivator activity | YY1; SRA1; LPIN2; SCAND1; MED16; HSF2; GTF2F1; GRIP1; MYOD1; NR2F1 |
| transcription corepressor activity | HDAC7A; FEV; CTBP2A; NCOR2; SKIL; SKOR1B; PPP1R13L; TLE2; HOMEZ; ATF5 |
| transcription factor binding | Ar; PPP1R13BB; TCF7L2; EPN1; HOXA7; HEY2; ATG7; HDAC8; APBB2; PIAS2 |
SP100 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SP100 here. Most of them are supplied by our site. Hope this information will be useful for your research of SP100.
SUMO1; UL123; CASP8AP2; ACTN2
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