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SP2

Official Full Name

Sp2 transcription factor
Overview

This gene encodes a member of the Sp subfamily of Sp/XKLF transcription factors. Sp family proteins are sequence-specific DNA-binding proteins characterized by an amino-terminal trans-activation domain and three carboxy-terminal zinc finger motifs. This protein contains the least conserved DNA-binding domain within the Sp subfamily of proteins, and its DNA sequence specificity differs from the other Sp proteins. It localizes primarily within subnuclear foci associated with the nuclear matrix, and can activate or in some cases repress expression from different promoters.
Synonyms

SP2; Sp2 transcription factor; transcription factor Sp2; KIAA0048; OTTHUMP00000196580; SP2_HUMAN; SPECIFICITY PROTEIN 2;

Type

Recombinant Proteins
Cell & Tissue Lysates
Protein Pre-coupled Magnetic Beads

Species

Human
Mouse
Rhesus Macaque
Zebrafish

Source

HEK293
In Vitro Cell Free System
Mammalian Cell
Wheat Germ

Tag

His
His (Fc)
Avi
N/A

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	SP2-31434TH	Recombinant Human SP2	Wheat Germ	N/A	249 amino acids	Inquiry
Human	SP2-31435TH	Recombinant Human SP2	Wheat Germ	N/A	91 amino acids	Inquiry
Human	SP2-1676HCL	Recombinant Human SP2 cell lysate		N/A		Inquiry
Human	SP2-489HF	Recombinant Full Length Human SP2 Protein	In Vitro Cell Free System		249 amino acids	Inquiry
Mouse	SP2-15793M	Recombinant Mouse SP2 Protein	Mammalian Cell	His		Inquiry
Mouse	SP2-8596M	Recombinant Mouse SP2 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Mouse	SP2-8596M-B	Recombinant Mouse SP2 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Rhesus Macaque	SP2-4418R	Recombinant Rhesus monkey SP2 Protein, His-tagged	Mammalian Cell	His		Inquiry
Rhesus Macaque	SP2-4234R	Recombinant Rhesus Macaque SP2 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Rhesus Macaque	SP2-4234R-B	Recombinant Rhesus Macaque SP2 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Zebrafish	SP2-5794Z	Recombinant Zebrafish SP2	Mammalian Cell	His		Inquiry

Involved Pathway
Protein Function
Interacting Protein

SP2 involved in several pathways and played different roles in them. We selected most pathways SP2 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with SP2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein

SP2 has several biochemical functions, for example, DNA binding, RNA polymerase II transcription factor activity, sequence-specific DNA binding, histone deacetylase binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SP2 itself. We selected most functions SP2 had, and list some proteins which have the same functions with SP2. You can find most of the proteins on our site.

Function	Related Protein
DNA binding	AHRRA;CERS4;GLIS2;CREB1B;FOXP2;KRBA2;ZNF43;SP2;PRDM13
RNA polymerase II transcription factor activity, sequence-specific DNA binding	FLI1B;FOXA1;ZNF174;FOXG1B;TAL1;FOXK1;KLF11;ZNF131;FOXA
histone deacetylase binding	CRY1;SP1;ZMYND15;PRDM1;TOP2B;RAD9A;DDX20;RFXANK;PARK2
metal ion binding	BGLAP2;BNC2;ZFP42;RNFT1;FIBCD1;PVALB7;EYA3;ZBTB22;PPP2R3C
protein binding	SRGAP3;IFT122;SIT1;SLC22A3;SSB;TACR1;TBRG4;SPRED2;AKT1

SP2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SP2 here. Most of them are supplied by our site. Hope this information will be useful for your research of SP2.

BANP; MCM7; FHL2