srf
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  • Official Full Name
  • serum response factor (c-fos serum response element-binding transcription factor)
  • Background
  • This gene encodes a ubiquitous nuclear protein that stimulates both cell proliferation and differentiation. It is a member of the MADS (MCM1, Agamous, Deficiens, and SRF) box superfamily of transcription factors. This protein binds to the serum response element (SRE) in the promoter region of target genes. This protein regulates the activity of many immediate-early genes, for example c-fos, and thereby participates in cell cycle regulation, apoptosis, cell growth, and cell differentiation. This gene is the downstream target of many pathways; for example, the mitogen-activated protein kinase pathway (MAPK) that acts through the ternary complex factors (TCFs).
  • Synonyms
  • SRF; serum response factor (c-fos serum response element-binding transcription factor); serum response factor; MCM1
Cat.#:SRF-1863MTag:His|SUMO
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse SRF Protein (1-504 aa), His-SUMO-tagged
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Cat.#:SRF-2460HTag:His
Source (Host):YeastSpecies:Human
Product nameRecombinant Human SRF Protein (1-508 aa), His-tagged
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Cat.#:SRF-2746HTag:Myc|DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human SRF Protein, MYC/DDK-tagged
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Cat.#:SRF-102HTag:His
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human SRF, His-tagged
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Cat.#:SRF-2719HTag:His|T7
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human SRF protein, His & T7-tagged
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Cat.#:SRF-2948HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human SRF, His-tagged
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Cat.#:SRF-30614THTag:N/A
Source (Host):Wheat germSpecies:Human
Product nameRecombinant Human SRF
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Cat.#:SRF-15977MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse SRF Protein
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Cat.#:SRF-4551CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken SRF
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Involved Pathway

SRF involved in several pathways and played different roles in them. We selected most pathways SRF participated on our site, such as MAPK signaling pathway, cGMP-PKG signaling pathway, HTLV-I infection, which may be useful for your reference. Also, other proteins which involved in the same pathway with SRF were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
MAPK signaling pathway
MAPKAPK2A; JUND; CACNB3; RPS6KA3B; HRAS; CACNB4; RPS6KA5; FAS; Fasl; FGFR1
cGMP-PKG signaling pathway
CALM1; VASP; NFATC1; KCNMB4; INS1; PDE2A; GUCY1A3; PPP1R12A; CALML5; PRKG1
HTLV-I infection
FZD5; MSX2; WNT7A; POLD2; WNT10B; H2-Q10; KAT2B; ITGB2; CRTC3; FZD10
Viral carcinogenesis
HLA-C; TRADD; SCRIB; YWHAE; HIST1H2BQ; KAT2B; PIK3CB; HIST1H2BG; DLG1; ATF4

Protein Function

SRF has several biochemical functions, for example, RNA polymerase II core promoter proximal region sequence-specific DNA binding, chromatin DNA binding, histone deacetylase binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SRF itself. We selected most functions SRF had, and list some proteins which have the same functions with SRF. You can find most of the proteins on our site.
Function
Related Protein
Function RNA polymerase II core promoter proximal region sequence-specific DNA binding
Related Protein NFKB2; SALL1; TBX3; NFIA; YBX1; SMAD2; MAFB; MYF5; TBP; PHOX2B
Function chromatin DNA binding
Related Protein INSM1A; GRHL3; THRB; APEX1; EZH2; HIST1H1A; GRHL2; MED1; ZIC2; GRHL1
Function histone deacetylase binding
Related Protein DHX36; RAD9; RUNX2; RAD9A; HEY2; ANKRD1; ZNF703; SP2; BRMS1L; HIF1A
Function primary miRNA binding
Related Protein DGCR8; SRF
Function protein binding
Related Protein PLXNB2; EMD; MAPK7; TEN1; GRIK3; PAK3; NFKB2; GNAI1; PLEKHG2; RFPL3
Function protein homodimerization activity
Related Protein AGXT; USF2; HEXB; SLC26A5; PRDM6; CHKA; PDXK; IKBKG; DPY30; DRD2
Function serum response element binding
Related Protein NKX2-5; SRF; NKX2
Function contributes_to transcription factor activity, RNA polymerase II core promoter sequence-specific
Related Protein SRF; NKX3-1
Function transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding
Related Protein SFPI1; AHR; POU4F1; NR1H4; USF1; IRF8; GATA6; ATF1; NKX2-1; GLI1
Function transcription factor activity, RNA polymerase II transcription factor binding
Related Protein MYOCD; LHX2; MAMSTR; SRF; GATA4; TWIST2; THRAA; NACC2; SMAD4; GTF2E1
Function transcription factor activity, sequence-specific DNA binding
Related Protein NKX3-1; NFIL3-6; ATF7A; HOXB4A; KLF4; ZNF74; FLI1A; STAT1B; ETV5A; RCOR2
Function transcription factor binding
Related Protein SORBS3; SMARCA4; TNFRSF10A; GATA2; PIANP; MAFB; SMARCD3; NAAA; EGR1; RBL1
Function transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
Related Protein GLIS2; YBX1; ONECUTL; PHOX2B; AKNA; PAX5; SOX9; NKX2-5; NFATC3; NRF1
Function transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
Related Protein ETV5; GATA2; OVOL2; STAG2; FOXF2; MAFBB; HOXD8; CSRNP1; GRHL2; NR1I2

Interacting Protein

SRF has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SRF here. Most of them are supplied by our site. Hope this information will be useful for your research of SRF.
MKL2; MKL1; MYOD1; MYOG; MYOCD; ALDH3A1; CIRBP; q8clf6_yerpe

SRF Related Articles

Olar, A; He, DD; et al. Biologic correlates and significance of axonogenesis in prostate cancer. HUMAN PATHOLOGY 45:1358-1364(2014).
Shyu, KG; Cheng, WP; et al. Hypoxia activates muscle-restricted coiled-coil protein (MURC) expression via transforming growth factor-beta in cardiac myocytes. CLINICAL SCIENCE 126:367-375(2014).