• Official Full Name
  • STEAP family member 2, metalloreductase
  • Background
  • This gene is a member of the STEAP family and encodes a multi-pass membrane protein that localizes to the Golgi complex, the plasma membrane, and the vesicular tubular structures in the cytosol. A highly similar protein in mouse has both ferrireductase and cupric reductase activity, and stimulates the cellular uptake of both iron and copper in vitro. Increased transcriptional expression of the human gene is associated with prostate cancer progression. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
  • Synonyms
  • STEAP2; STEAP family member 2, metalloreductase; PCANAP1, prostate cancer associated protein 1 , six transmembrane epithelial antigen of the prostate 2; metalloreductase STEAP2; IPCA 1; STAMP1; STMP; prostate cancer associated protein 1; prostate cancer
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human STEAP2 protein, GST-tagged
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human STEAP2 protein, GST-tagged
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human STEAP2, His-tagged

Involved Pathway

STEAP2 involved in several pathways and played different roles in them. We selected most pathways STEAP2 participated on our site, such as Mineral absorption, which may be useful for your reference. Also, other proteins which involved in the same pathway with STEAP2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Mineral absorption

Protein Function

STEAP2 has several biochemical functions, for example, cupric reductase activity, ferric-chelate reductase (NADPH) activity, metal ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by STEAP2 itself. We selected most functions STEAP2 had, and list some proteins which have the same functions with STEAP2. You can find most of the proteins on our site.
Related Protein
Function cupric reductase activity
Related Protein STEAP3; STEAP4; STEAP2
Function ferric-chelate reductase (NADPH) activity
Related Protein STEAP3; STEAP2; STEAP4
Function metal ion binding
Related Protein CAR3; ZNF410; ILKAP; LRRK1; Itgam&Itgb2; ITGA6; JAZF1B; ZNF70; ENDOG; ZNF781
Function transporter activity
Related Protein ATP6V1C1; AQP9A; SLC4A1A; AQP12B; AP3D1; SLC15A2; LCN15; SLC4A4A; MFSD10; RBP2

STEAP2 Related Articles

Grunewald, TGP; Bach, H; et al. The STEAP protein family: Versatile oxidoreductases and targets for cancer immunotherapy with overlapping and distinct cellular functions. BIOLOGY OF THE CELL 104:641-657(2012).
McCarthy, RC; Kosman, DJ; et al. Mechanistic analysis of iron accumulation by endothelial cells of the BBB. BIOMETALS 25:665-675(2012).
Vaghjiani, RJ; Talma, S; et al. Six-Transmembrane Epithelial Antigen of the Prostate (STEAP1 and STEAP2)-Differentially Expressed by Murine and Human Mesenchymal Stem Cells. TISSUE ENGINEERING PART A 15:2073-2083(2009).