surf1
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  • Official Full Name
  • surfeit 1
  • Background
  • This gene encodes a protein localized to the inner mitochondrial membrane and thought to be involved in the biogenesis of the cytochrome c oxidase complex. The protein is a member of the SURF1 family, which includes the related yeast protein SHY1 and rickettsial protein RP733. The gene is located in the surfeit gene cluster, a group of very tightly linked genes that do not share sequence similarity, where it shares a bidirectional promoter with SURF2 on the opposite strand. Defects in this gene are a cause of Leigh syndrome, a severe neurological disorder that is commonly associated with systemic cytochrome c oxidase deficiency.
  • Synonyms
  • SURF1; surfeit 1; surfeit locus protein 1; MS403; OTTHUMP00000022473; OTTHUMP00000022474; SURF 1; SURF-1; SURF1_HUMAN
Cat.#:SURF1-1830HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Surfeit 1, His tagged
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Cat.#:SURF1-3060HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human SURF1, His-tagged
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Cat.#:SURF1-31483THTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human SURF1, His-tagged
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Cat.#:SURF1-16252MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse SURF1 Protein
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Cat.#:SURF1-5843RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat SURF1 Protein
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Cat.#:Surf1-8133RTag:His/GST
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Surf1 protein, His & GST-tagged
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Cat.#:SURF1-1983CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken SURF1
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Cat.#:SURF1-5032ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish SURF1
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Cat.#:SURF1-1337HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human SURF1 293 Cell Lysate
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Involved Pathway

SURF1 involved in several pathways and played different roles in them. We selected most pathways SURF1 participated on our site, such as Electron Transport Chain, Gene Expression, Generic Transcription Pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with SURF1 were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Electron Transport Chain
COX6B1; UCP2; COX4I1; COX15; ATP5H; COX11; NDUFS7; ATPIF1; SCO1; ATP5L
Gene Expression
DDX4; IGF2BP1; ZNF285A; A1CF; ZNF383; ZNF227; CTDP1; TPRKB; DNMT3A; POLR3C
Generic Transcription Pathway
COX8A; RORAA; NR6A1A; ZFP30; SCO1; ZNF205; ZNF498; ZIM3; ZNF668; SURF1
Metabolism
ARSK; CLPS; Sult2a2; AGL; GLIPR1; B3GNT1; OAZ1; CYP17A1; ACOT11B; FA2H
Respiratory electron transport
COX18; NDUFAF6; SURF1; NDUFAF7; LRPPRC; COX11; NDUFAF5; ETFB; NDUFAF2; TIMMDC1
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
SLC25A14; NDUFAF5; ETFDH; UCP3; C20orf7; NDUFAF6; SCO1; LRPPRC; ATP5S; ATP5L
TP53 Regulates Metabolic Genes
PRDX2; COX18; SESN3; COX16; FAM36A; COX14; TACO1; LRPPRC; SURF1; SCO1
The citric acid (TCA) cycle and respiratory electron transport
NDUFAF2; SCO1; PDK3; NDUFAF5; COX18; PDPR; UCP2; MPC1; NDUFAF6; PDP1

Protein Function

SURF1 has several biochemical functions, for example, cytochrome-c oxidase activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SURF1 itself. We selected most functions SURF1 had, and list some proteins which have the same functions with SURF1. You can find most of the proteins on our site.
Function
Related Protein
Function cytochrome-c oxidase activity
Related Protein COX7A3; COX5B; COX7B2; COX5AA; COX7A2L; COX7B; COX6B2; COX5A; COX6A1; CYB5A
Function protein binding
Related Protein LATS2; SSRP1; HOXB9; NCS1; FLI1; CHMP1B; BNIP3L; FAM117B; THSD4; KLHL6

Interacting Protein

SURF1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SURF1 here. Most of them are supplied by our site. Hope this information will be useful for your research of SURF1.
COA3; PTGES3; SLC25A5; COX6C; COX14; COA1