SURF1
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Official Full Name
surfeit 1
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Overview
This gene encodes a protein localized to the inner mitochondrial membrane and thought to be involved in the biogenesis of the cytochrome c oxidase complex. The protein is a member of the SURF1 family, which includes the related yeast protein SHY1 and rickettsial protein RP733. The gene is located in the surfeit gene cluster, a group of very tightly linked genes that do not share sequence similarity, where it shares a bidirectional promoter with SURF2 on the opposite strand. Defects in this gene are a cause of Leigh syndrome, a severe neurological disorder that is commonly associated with systemic cytochrome c oxidase deficiency. -
Synonyms
SURF1; surfeit 1; surfeit locus protein 1; MS403; OTTHUMP00000022473; OTTHUMP00000022474; SURF 1; SURF-1; SURF1_HUMAN;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Arabidopsis thaliana (Mouse-ear cress)
- Chicken
- Drosophila melanogaster (Fruit fly)
- Gallus gallus (Chicken)
- Homo sapiens (Human)
- Human
- Mouse
- Mus musculus (Mouse)
- Rat
- Rattus norvegicus (Rat)
- Takifugu rubripes (Japanese pufferfish) (Fugu rubripes)
- Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
- Zebrafish
- E.coli
- E.coli expression system
- HEK293
- Mammalian Cell
- His
- His (Fc)
- Avi
- His|GST
- N/A
| Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| Human | SURF1-31483TH | Recombinant Human SURF1, His-tagged | E.coli | His | 194 amino acids |
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| Human | SURF1-1830H | Recombinant Human Surfeit 1, His tagged | E.coli | His |
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| Human | SURF1-3060H | Recombinant Human SURF1, His-tagged | E.coli | His | 1-300aa | |
| Human | SURF1-1337HCL | Recombinant Human SURF1 293 Cell Lysate | HEK293 | N/A |
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| Mouse | SURF1-16252M | Recombinant Mouse SURF1 Protein | Mammalian Cell | His |
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| Mouse | SURF1-8881M | Recombinant Mouse SURF1 Protein, His (Fc)-Avi-tagged | HEK293 | His (Fc)-Avi |
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| Mouse | SURF1-8881M-B | Recombinant Mouse SURF1 Protein Pre-coupled Magnetic Beads | HEK293 |
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| Rat | SURF1-5843R | Recombinant Rat SURF1 Protein | Mammalian Cell | His |
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| Rat | Surf1-8133R | Recombinant Rat Surf1 protein, His & GST-tagged | E.coli | His/GST | Met1~Val306 (Accession # Q9QXU2) |
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| Rat | SURF1-5502R | Recombinant Rat SURF1 Protein, His (Fc)-Avi-tagged | HEK293 | His (Fc)-Avi |
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| Rat | SURF1-5502R-B | Recombinant Rat SURF1 Protein Pre-coupled Magnetic Beads | HEK293 |
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| Arabidopsis thaliana (Mouse-ear cress) | RFL31692AF | Recombinant Full Length Arabidopsis Thaliana Surfeit Locus Protein 1(Surf1) Protein, His-Tagged | E.coli expression system | His | Full Length (1-354) |
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| Drosophila melanogaster (Fruit fly) | RFL21643DF | Recombinant Full Length Drosophila Melanogaster Surf1-Like Protein(Surf1) Protein, His-Tagged | E.coli expression system | His | Full Length (1-300) |
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| Gallus gallus (Chicken) | RFL25340GF | Recombinant Full Length Chicken Surfeit Locus Protein 1(Surf1) Protein, His-Tagged | E.coli expression system | His | Full Length (1-309) |
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| Homo sapiens (Human) | RFL24015HF | Recombinant Full Length Human Surfeit Locus Protein 1(Surf1) Protein, His-Tagged | E.coli expression system | His | Full Length (1-300) |
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| Mus musculus (Mouse) | RFL6088MF | Recombinant Full Length Mouse Surfeit Locus Protein 1(Surf1) Protein, His-Tagged | E.coli expression system | His | Full Length (1-306) |
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| Rattus norvegicus (Rat) | RFL18658RF | Recombinant Full Length Rat Surfeit Locus Protein 1(Surf1) Protein, His-Tagged | E.coli expression system | His | Full Length (1-306) |
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| Takifugu rubripes (Japanese pufferfish) (Fugu rubripes) | RFL34751TF | Recombinant Full Length Takifugu Rubripes Surfeit Locus Protein 1(Surf1) Protein, His-Tagged | E.coli expression system | His | Full Length (1-240) |
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| Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) | RFL12959XF | Recombinant Full Length Xenopus Tropicalis Surfeit Locus Protein 1(Surf1) Protein, His-Tagged | E.coli expression system | His | Full Length (1-307) |
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| Zebrafish | SURF1-5032Z | Recombinant Zebrafish SURF1 | Mammalian Cell | His |
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| Chicken | SURF1-1983C | Recombinant Chicken SURF1 | Mammalian Cell | His |
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- Involved Pathway
- Protein Function
- Interacting Protein
SURF1 involved in several pathways and played different roles in them. We selected most pathways SURF1 participated on our site, such as Electron Transport Chain, Gene Expression, Generic Transcription Pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with SURF1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Electron Transport Chain | SLC25A14;COX7A2;COX17;NDUFS7;COX7C;UCP3;ATPIF1;COX15;COX5B |
| Gene Expression | GTF3C3;PRPF8;ZNF738;NR1D2A;PLD6;COX6C;ZFP1;TSN;PHF1 |
| Generic Transcription Pathway | Txn1;ZNF713;PRDM7;ZKSCAN1;ZNF777;COX6A1;ZNF230;ZNF684;USP9 |
| Metabolism | CBLC-1;UGT1B4;GSTK1;CKB;PFKLB;CYP2K6;ARSD;SYT5;CYP4T8 |
| Respiratory electron transport | LRPPRC;NDUFAF3;FAM36A;NDUFAF2;ETFB;NDUFAF7;C2orf56;NDUFAF6;C20orf7 |
| Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. | COX14;SLC25A14;LRPPRC;NDUFAF2;COX16;ETFA;SCO1;ETFB;NDUFAF7 |
| TP53 Regulates Metabolic Genes | SESN3;PRDX2;SCO1;TACO1;COX16;COX18;FAM36A;LRPPRC;SURF1 |
| The citric acid (TCA) cycle and respiratory electron transport | TACO1;C20orf7;PDK3;NDUFAF5;COX16;PDPR;NDUFAF2;PDK4;SURF1 |
SURF1 has several biochemical functions, for example, cytochrome-c oxidase activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SURF1 itself. We selected most functions SURF1 had, and list some proteins which have the same functions with SURF1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| cytochrome-c oxidase activity | COX5B;COX5B2;CYB5A;COX11;COX7C;COX6A1;COX7A1;COX7B;COX6B2 |
| protein binding | PSMC2;ULK3;RPL9;NDC80;IDE;TXLNG;ARHGEF40;ANKS4B;RCC2 |
SURF1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SURF1 here. Most of them are supplied by our site. Hope this information will be useful for your research of SURF1.
COA3; PTGES3; SLC25A5; COX6C; COX14; COA1
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