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SYK

  • Official Full Name

    spleen tyrosine kinase

  • Overview

    Syk (72 kDa) is a non-receptor protein tyrosine kinase that plays a central role in immune receptor signal transduction and is implicated in endothelial cell functions, including cell growth and migration. Syk is activated upon binding to immunoreceptor t
  • Synonyms

    SYK; spleen tyrosine kinase; tyrosine-protein kinase SYK; p72-Syk; FLJ25043; FLJ37489; DKFZp313N1010;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Assay Kits
  • Chicken
  • Human
  • Mouse
  • Rat
  • Rhesus Macaque
  • Zebrafish
  • E.coli
  • HEK293
  • HEK293T
  • Insect (sf21)
  • Insect Cell
  • Mammalian Cell
  • Mammalian cells
  • Sf9 Insect Cell
  • C
  • Myc
  • DDK
  • Flag
  • GST
  • His
  • His (Fc)
  • Avi
  • His|Flag
  • Myc|DDK
  • N/A
  • N
  • No tag
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human SYK-1491H Active Recombinant Human SYK, GST-tagged Sf9 Insect Cell GST Full length
Human SYK-557H Active Recombinant Human SYK, GST-tagged Sf9 Insect Cell GST
Human SYK-715H Recombinant Human Spleen Tyrosine Kinase, GST-His Sf9 Insect Cell GST
Human SYK-31488TH Recombinant Human SYK N/A
Human SYK-439H Recombinant Human Spleen Tyrosine Kinase, GST-tagged, Active Sf9 Insect Cell GST
Human SYK-3069H Recombinant Human SYK, His-tagged E.coli His 367-635aa
Human SYK-81H Recombinant Human SYK protein, Flag-tagged, Biotinylated Insect Cell Flag
Human SYK-1320HCL Recombinant Human SYK 293 Cell Lysate HEK293 N/A
Human SYK-0753H Recombinant Human SYK Protein (E356-N635), His tagged Insect Cell His E356-N635
Human SYK-030H Recombinant Human SYK Protein, MYC/DDK-tagged, C13 and N15-labeled HEK293 C-Myc/DDK
Human SYK-109H Recombinant Human SYK Protein, His-FLAG-tagged HEK293 His/Flag
Human SYK-6584HF Active Recombinant Full Length Human SYK Protein, DDK-tagged, Biotinylated Insect (sf21) DDK 1-635(end)
Human SYK17089H Recombinant Human SYK (356-635) Protein
Human SYK-7918HF Active Recombinant Full Length Human SYK Protein, DDK-tagged, Biotinylated Insect (sf21) DDK 1-635(end)
Human SYK-35H Recombinant Human SYK Protein, MYC/DDK-tagged HEK293 Myc/DDK
Human SYK-4845HF Active Recombinant Full Length Human SYK Protein, GST-tagged Insect (sf21) GST 1-635(end)
Human SYK-376HFL Recombinant Full Length Human SYK Protein, C-Flag-tagged Mammalian cells Flag
Human SYK-2144H-B Recombinant Human SYK Protein Pre-coupled Magnetic Beads HEK293
Human SYK-2144H Recombinant Human SYK Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human SYK-307H Active Recombinant Human SYK protein, His-tagged E.coli His Asp374~Asn635
Human SYK-0754H Recombinant Human SYK Protein (E356-N635), Tag Free Insect Cell No tag E356-N635
Human SYK-3070H Recombinant Human SYK protein, GST-tagged E.coli GST 367-635 aa
Human SYK-3071H Recombinant Human SYK protein, His-tagged E.coli His 239-427 aa
Human SYK-6385H Recombinant Human SYK Protein (Asp374-Asn635), N-His tagged E.coli N-His Asp374-Asn635
Mouse SYK-16300M Recombinant Mouse SYK Protein Mammalian Cell His
Mouse Syk-1187M Recombinant Mouse Syk protein, His-tagged E.coli His Glu340~Val607
Mouse SYK-8908M-B Recombinant Mouse SYK Protein Pre-coupled Magnetic Beads HEK293
Mouse Syk-6245M Recombinant Mouse Syk Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mouse SYK-8908M Recombinant Mouse SYK Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat SYK-5859R Recombinant Rat SYK Protein Mammalian Cell His
Rat SYK-5518R Recombinant Rat SYK Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat SYK-5518R-B Recombinant Rat SYK Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque SYK-4578R Recombinant Rhesus monkey SYK Protein, His-tagged Mammalian Cell His
Rhesus Macaque SYK-4394R Recombinant Rhesus Macaque SYK Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque SYK-4394R-B Recombinant Rhesus Macaque SYK Protein Pre-coupled Magnetic Beads HEK293
Zebrafish SYK-12105Z Recombinant Zebrafish SYK Mammalian Cell His
Chicken SYK-3079C Recombinant Chicken SYK Mammalian Cell His
Kit-1625 SYK Activity Assay Kit N/A
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • SYK Related Articles
  • SYK Related Research Area

SYK involved in several pathways and played different roles in them. We selected most pathways SYK participated on our site, such as NF-kappa B signaling pathway, Phospholipase D signaling pathway, PIK-Akt signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with SYK were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
NF-kappa B signaling pathwayTNFRSF11A;BCL2A1A;LTB;PIDD1;TAB2;CD40;PLCG1;LYN;IL1R1
Phospholipase D signaling pathwayGNAS;FYN;Adcy4;MAP2K2;RAF1;AGPAT4;GRM1;PLA2G4F;KIT
PIK-Akt signaling pathwayKitl;ITGA10;GNG11;PDPK1;PPP2R5D;ANGPT4;GRB2;IKBKB;PIK3R1
Osteoclast differentiationSIRPG;IFNG;IKBKB;MAP3K14;LILRB5;SFPI1;PIK3CG;FCGR2B;MAP2K1
Platelet activationITPR1;ARHGEF12;LCP2;P2RY1;MYLK2;PPP1R12A;LYN;GP1BB;PIK3R1
Natural killer cell mediated cytotoxicityMICB;KLRC4-KLRK1;IFNAR2;ICAM2;HCST;IFNA7;Ifna11;HLA-G;IFNGR2
B cell receptor signaling pathwayRELA;MAP2K1;PTPN18;CD79B;Cd79a, Cd79b;NFKBIB;PIK3R5;PTPN6;CRK
Fc epsilon RI signaling pathwayIL4;PIK3CG;PIK3R2;LYN;MAPK9;VAV3;HRAS;MAPK12;MS4A2
Fc gamma R-mediated phagocytosisLAT;PRKCG;ASAP3;VAV3;GSN;SPHK1;PIK3R2;VAV2;MAP2K1
TuberculosisIL10RB;FCGR3B;PMAP-36;BID;HLA-DOA;TLR9;SPHK2;TNFRSF1A;PPP3R1
Epstein-Barr virus infectionPLCG2;POLR2J2;TBPL1;IL10RA;NFKB2;PSMD8;PSMC2;GSK3B;YWHAG
Viral carcinogenesisHIST1H2BI;BAX;PKM2;MAPK3;HIST1H2BK;PIK3CG;HIST1H4I;Casp3;HIST1H4E

SYK has several biochemical functions, for example, ATP binding, integrin binding, non-membrane spanning protein tyrosine kinase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by SYK itself. We selected most functions SYK had, and list some proteins which have the same functions with SYK. You can find most of the proteins on our site.

Function Related Protein
ATP bindingSTK40;SYN3;HELLS;DDX19;RIPK1;CLPX;UBE2U;PI4K2A;DDX52
integrin bindingFN1A;ITGA6;L1CAM;WISP2;LYN;EGFL6;ITGB1;SRC;MMP14
non-membrane spanning protein tyrosine kinase activityBTK;ZNF143B;TNK2B;PKDCC;PRKCD;JAK2B;ABL2;STK16;MELK
protein bindingHHLA2;MYO10;PNKP;AP3S1;HHEX;PAK4;HSFX1;RPS26;MRPL53
protein kinase activityBMPR1BB;CSNK1E;PPP1R9B;PTK6B;PRKCHA;CDK7;LIMK1;PLK1;MAP4K1
protein kinase bindingCAMK2N1;CCNA2;TICAM1;BAD;PTPRJ;PTPN6;AXIN2;ADIPOR1;ELAVL1
protein serine/threonine kinase activityTTK;DCLK3;MAP2K7;STK11;MAP3K9;ROCK2B;DYRK2;MAPK14;ADCK5
protein tyrosine kinase activityCSF1RA;INSRB;LYN;INSRA;ABL2;EPHA2A;JAK2A;ERBB3B;PTK2
receptor signaling protein tyrosine kinase activityERBB3B;EGFRA;KITA;EGFR;INSR;ERBB4A;TYRO3;ERBB4;KITB

SYK has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SYK here. Most of them are supplied by our site. Hope this information will be useful for your research of SYK.

LCK; CBL; STAT3; USP25

Chandran, SR; Tesch, GH; et al. Spleen tyrosine kinase contributes to acute renal allograft rejection in the rat. INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY 96:54-62(2015).
Khairnar, V; Duhan, V; et al. CEACAM1 induces B-cell survival and is essential for protective antiviral antibody production. NATURE COMMUNICATIONS 6:-(2015).
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