syk
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  • Official Full Name
  • spleen tyrosine kinase
  • Background
  • Syk (72 kDa) is a non-receptor protein tyrosine kinase that plays a central role in immune receptor signal transduction and is implicated in endothelial cell functions, including cell growth and migration. Syk is activated upon binding to immunoreceptor t
  • Synonyms
  • SYK; spleen tyrosine kinase; tyrosine-protein kinase SYK; p72-Syk; FLJ25043; FLJ37489; DKFZp313N1010
Cat.#:SYK-35HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human SYK Protein, MYC/DDK-tagged
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Cat.#:SYK-109HTag:His-FLAG
Source (Host):HEK293Species:Human
Product nameRecombinant Human SYK Protein, His-FLAG-tagged
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Cat.#:SYK-3069HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human SYK, His-tagged
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Cat.#:SYK-31488THTag:
Source (Host):Species:Human
Product nameRecombinant Human SYK
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Cat.#:SYK-439HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human Spleen Tyrosine Kinase, GST-tagged, Active
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Cat.#:SYK-557HTag:GST
Source (Host):Sf 9 insect cellsSpecies:Human
Product nameRecombinant Human SYK, GST-tagged
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Cat.#:SYK-715HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human Spleen Tyrosine Kinase, GST-His
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Cat.#:SYK-81HTag:Flag
Source (Host):Insect cellSpecies:Human
Product nameRecombinant Human SYK protein, Flag-tagged, Biotinylated
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Cat.#:Syk-1187MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Syk protein, His-tagged
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Cat.#:SYK-16300MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse SYK Protein
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Cat.#:SYK-5859RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat SYK Protein
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Cat.#:SYK-4578RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey SYK Protein, His-tagged
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Cat.#:SYK-3079CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken SYK
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Cat.#:SYK-12105ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish SYK
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Cat.#:SYK-1491HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human SYK (Active), GST-tagged
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Cat.#:SYK-1320HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human SYK 293 Cell Lysate
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Cat.#:Kit-1625Tag:
Source (Host):Species:
Product nameSYK Activity Assay Kit
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Involved Pathway

SYK involved in several pathways and played different roles in them. We selected most pathways SYK participated on our site, such as NF-kappa B signaling pathway, Phospholipase D signaling pathway, PIK-Akt signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with SYK were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
NF-kappa B signaling pathway
PLCG2; ZAP70; TNFSF13B; CCL4L1; PRKCB; BLNK; MAP3K7; TRAF2; GM1987; ICAM1
Phospholipase D signaling pathway
HRAS; SOS1; RALGDS; GRM3; PLCB2; PPAP2B; PLCG1; MAPK1; AGPAT5; Kitl
PIK-Akt signaling pathway
Il2; FGFR4; GNB1; IFNA6; IL3RA; PDGFA; ITGA10; THBS1; G6PC2; PIK3R5
Osteoclast differentiation
SOCS3; SIRP-BETA; GAB2; TGFBR1; FCGR2A; SQSTM1; CYBB; IKBKB; SFPI1; RELB
Platelet activation
ARHGEF12; ACTG1; GP9; P2RX1; STIM1; COL27A1; PLCB3; RAP1B; PLCB4; MYL12A
Natural killer cell mediated cytotoxicity
GM-CSF; PRKCA; FCGR3A; CD247; KLRC2; HLA-B; ULBP3; KIR3DL1; FCER1G; KIR2DS3
B cell receptor signaling pathway
HDAC5; RAC1; CMTM3; ARPC1B; LAT2; DOK1; PIK3R3; GSK3AB; VAV1; PIK3CG
Fc epsilon RI signaling pathway
PIK3CD; MAPK11; PIK3CB; MAP2K7; MAPK8; PLCG1; SYK; PLCG2; PLA2G4F; RAC1
Fc gamma R-mediated phagocytosis
ARPC5L; WASL; PIP5K1C; MARCKSL1; MAPK1; ASAP1; PLA2G4D; PIK3R2; VAV2; DOCK2
Tuberculosis
MAPK12; IRAK4; SYK; LBP; CORO1A; IFNA1; KSR1; ARHGEF12; IRAK1; CASP8
Epstein-Barr virus infection
GTF2E2; PIK3CA; POLR3G; CD38; YWHAZ; YWHAH; MDM2; POLR3B; POLR2C; PSMC1
Viral carcinogenesis
CREB5; HDAC11; SYK; CCND3; PIK3R5; HIST1H2BA; MAPK3; ACTN4; MAPKAPK2; NRAS

Protein Function

SYK has several biochemical functions, for example, ATP binding, integrin binding, non-membrane spanning protein tyrosine kinase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by SYK itself. We selected most functions SYK had, and list some proteins which have the same functions with SYK. You can find most of the proteins on our site.
Function
Related Protein
Function ATP binding
Related Protein AK5; NLRP7; ABCG2A; DHX35; ADCK1; MYO1A; TRPV1; MB21D1; GRK7; LIG3
Function integrin binding
Related Protein VWF; ICAM1; CTGF; SEMA7A; CXADR; WISP1B; EDIL3; Npnt; ADAMTS8; SYK
Function non-membrane spanning protein tyrosine kinase activity
Related Protein MATK; EIF2AK2; FER; Fert2; PRKCD; STYK1; ZAP70; YES1; BTK; LCK
Function protein binding
Related Protein FYTTD1; PDE4D; ATP1B1; CCDC60; MAP2K7; ATP6V1F; CASP9; AAGAB; CLIP1; KRTAP19-5
Function protein kinase activity
Related Protein WEE2; MAP3K11; DCLK3; MYO3A; NRBP1; GRK7B; ERBB3B; TNIKB; PRKCI; MAPKAPK2A
Function protein kinase binding
Related Protein BCL10; LLGL1; MAVS; CRY1; AXIN2; SPRY2; CCND1; AP1B1; NSF; PLCG1
Function protein serine/threonine kinase activity
Related Protein AKT3A; CAMK1DB; STK25; BMPR1AB; OXSR1B; HIPK1; PKN2; LIMK1; ACVR2AA; DCLK3
Function protein tyrosine kinase activity
Related Protein JAK2; INSRA; ABL1; MAP2K4; FGFR1A; RET; BAZ1B; FYNA; IGF1RA; LCK
Function receptor signaling protein tyrosine kinase activity
Related Protein INSR; KITA; ERBB3B; KIT; TYRO3; ERBB4; EGFR; ERBB4A; EGFRA; ERBB2

Interacting Protein

SYK has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SYK here. Most of them are supplied by our site. Hope this information will be useful for your research of SYK.
LCK; CBL; STAT3; USP25

SYK Related Articles

Chandran, SR; Tesch, GH; et al. Spleen tyrosine kinase contributes to acute renal allograft rejection in the rat. INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY 96:54-62(2015).
Khairnar, V; Duhan, V; et al. CEACAM1 induces B-cell survival and is essential for protective antiviral antibody production. NATURE COMMUNICATIONS 6:-(2015).