syk
Share
  • Official Full Name
  • spleen tyrosine kinase
  • Background
  • Syk (72 kDa) is a non-receptor protein tyrosine kinase that plays a central role in immune receptor signal transduction and is implicated in endothelial cell functions, including cell growth and migration. Syk is activated upon binding to immunoreceptor t
  • Synonyms
  • SYK; spleen tyrosine kinase; tyrosine-protein kinase SYK; p72-Syk; FLJ25043; FLJ37489; DKFZp313N1010
Cat.#:SYK-35HTag:Myc|DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human SYK Protein, MYC/DDK-tagged
+Inquiry
Cat.#:SYK-109HTag:His|Flag
Source (Host):HEK293Species:Human
Product nameRecombinant Human SYK Protein, His-FLAG-tagged
+Inquiry
Cat.#:SYK-3069HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human SYK, His-tagged
+Inquiry
Cat.#:SYK-31488THTag:N/A
Source (Host):Species:Human
Product nameRecombinant Human SYK
+Inquiry
Cat.#:SYK-439HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human Spleen Tyrosine Kinase, GST-tagged, Active
+Inquiry
Cat.#:SYK-557HTag:GST
Source (Host):Sf 9 insect cellsSpecies:Human
Product nameRecombinant Human SYK, GST-tagged
+Inquiry
Cat.#:SYK-715HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human Spleen Tyrosine Kinase, GST-His
+Inquiry
Cat.#:SYK-81HTag:Flag
Source (Host):Insect cellSpecies:Human
Product nameRecombinant Human SYK protein, Flag-tagged, Biotinylated
+Inquiry
Cat.#:Syk-1187MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Syk protein, His-tagged
+Inquiry
Cat.#:SYK-16300MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse SYK Protein
+Inquiry
Cat.#:SYK-5859RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat SYK Protein
+Inquiry
Cat.#:SYK-4578RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey SYK Protein, His-tagged
+Inquiry
Cat.#:SYK-3079CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken SYK
+Inquiry
Cat.#:SYK-12105ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish SYK
+Inquiry
Cat.#:SYK-1491HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human SYK (Active), GST-tagged
+Inquiry
Cat.#:SYK-1320HCLTag:N/A
Source (Host):Species:Human
Product nameRecombinant Human SYK 293 Cell Lysate
+Inquiry
Cat.#:Kit-1625Tag:N/A
Source (Host):Species:
Product nameSYK Activity Assay Kit
+Inquiry

Involved Pathway

SYK involved in several pathways and played different roles in them. We selected most pathways SYK participated on our site, such as NF-kappa B signaling pathway, Phospholipase D signaling pathway, PIK-Akt signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with SYK were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
NF-kappa B signaling pathway
RELB; CARD11; BIRC3; IRAK4; BCL2A1; CD14; TNF; CCL21; PLCG1; ERC1
Phospholipase D signaling pathway
AGPAT5; PIK3R5; PLCB4; GRM6; PLCB3; KIT; PIK3R2; PTGFR; PDGFRA; GAB1
PIK-Akt signaling pathway
IL7R; LAMB4; INS1; FGF21; ANGPT1; ITGB4; IKBKB; ITGB6; ITGB7; TLR2
Osteoclast differentiation
FYN; CYLD; MAPK10; SPI1; TYK2; TGFBR1; FCGR1; CSF1R; LILRA4; PIK3R5
Platelet activation
TBXAS1; PLCB1; PIK3R5; LYN; PPP1CC; PIK3R1; ITGA2B; PTGIR; ARHGAP35; NOS3
Natural killer cell mediated cytotoxicity
IFNAR1; PPP3CB; TNF; TNFRSF10C; MICA; Ifna15; NCR2; Fasl; IFNAR2; IFNA2
B cell receptor signaling pathway
PLEKHA1; AKT1; PIK3CD; LYN; RAP2A; GSK3B; IGHM; PIK3CB; SLA2; SOS1
Fc epsilon RI signaling pathway
MAPK12; HRAS; PLA2G4A; IL3; VAV2; MAP2K3; VAV3; GRB2; PIK3R5; TNF
Fc gamma R-mediated phagocytosis
WASL; DOCK2; LYN; NCF1; ASAP2; PIK3R5; WASF3; HCK; CDC42; PAK1
Tuberculosis
KSR1; TNFRSF1A; IRAK1; H2-AA; HLA-DOB; TLR9; IFNA16; ATP6V0D1; CARD9; CD209B
Epstein-Barr virus infection
POLR2I; POLR3F; TAB2; PLCG2; TRAF3; POLR3D; HLA-DRA; EIF2AK3; ENTPD8; POLR1D
Viral carcinogenesis
HIST1H4L; HIST1H4G; PIK3R1; HIST3H2BB-PS; HLA-B; PIK3CG; H2-Q10; CCND3; HDAC4; LTBR

Protein Function

SYK has several biochemical functions, for example, ATP binding, integrin binding, non-membrane spanning protein tyrosine kinase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by SYK itself. We selected most functions SYK had, and list some proteins which have the same functions with SYK. You can find most of the proteins on our site.
Function
Related Protein
Function ATP binding
Related Protein OAS2; NME2A; ATAD1; PAPOLA; EPHB4B; CARKD; DDX23; TOR1B; MTHFD1L; CAMK1DA
Function integrin binding
Related Protein FERMT3; MMP14; PPAP2B; CIB2; ITGA6; WISP1A; TGFBI; IGF1; ADAM10; CD151
Function non-membrane spanning protein tyrosine kinase activity
Related Protein PKDCC; LYN; TEC; CSK; EIF2AK2; JAK3; ITK; JAK2; PTK6; FRK
Function protein binding
Related Protein ARL6IP4; TGOLN2; GFM2; KRTAP8-1; SNX11; C9orf86; TMEM31; FAM9B; CISH; BANK1
Function protein kinase activity
Related Protein CLK2B; PAN3; NEK10; CAMK2D1; GM4922; CASKA; BMPR1AB; GRK1; MAP2K2B; MAPK14A
Function protein kinase binding
Related Protein PPP1R12B; CCNA2; GHR; CCNL1A; PPME1; ZC3HC1; PKD1; RCC2; ADCY6; TOM1L1
Function protein serine/threonine kinase activity
Related Protein ACVR1; DAPK2; TLK1B; MARK2; PBK; TRIOA; MAP2K7; PKN1; AKT3A; PHKG1B
Function protein tyrosine kinase activity
Related Protein PTK2BB; EPHA4B; ALK; Fert2; PTK2AA; SHC1; RET; TNK2B; TYRO3; MUSK
Function receptor signaling protein tyrosine kinase activity
Related Protein TYRO3; KIT; LYN; ERBB4A; ERBB2; KITB; EGFR; ERBB4; EGFRA; KITA

Interacting Protein

SYK has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SYK here. Most of them are supplied by our site. Hope this information will be useful for your research of SYK.
LCK; CBL; STAT3; USP25

SYK Related Articles

Chandran, SR; Tesch, GH; et al. Spleen tyrosine kinase contributes to acute renal allograft rejection in the rat. INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY 96:54-62(2015).
Khairnar, V; Duhan, V; et al. CEACAM1 induces B-cell survival and is essential for protective antiviral antibody production. NATURE COMMUNICATIONS 6:-(2015).