Recombinant Full Length Human SYK Protein, C-Flag-tagged

• Cat.No.: SYK-376HFL
• Product Overview: Recombinant Full Length Human SYK Protein, fused to Flag-tag at C-terminus, was expressed in Mammalian cells.

Specification

• Description: This gene encodes a member of the family of non-receptor type Tyr protein kinases. This protein is widely expressed in hematopoietic cells and is involved in coupling activated immunoreceptors to downstream signaling events that mediate diverse cellular responses, including proliferation, differentiation, and phagocytosis. It is thought to be a modulator of epithelial cell growth and a potential tumour suppressor in human breast carcinomas. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
• Source: Mammalian cells
• Species: Human
• Tag: Flag
• Form: 25 mM Tris HCl, pH 7.3, 100 mM glycine, 10% glycerol.
• Molecular Mass: 71.9 kDa
• AA Sequence: MASSGMADSANHLPFFFGNITREEA EDYLVQGGMSDGLYLLRQSRNYLGG FALSVAHGRKAHHYTIEREL NGTYAIAGGRTHASPADLCHYHSQE SDGLVCLLKKPFNRPQGVQPKTGPF EDLKENLIREYVKQTWNLQG QALEQAIISQKPQLEKLIATTAHEK MPWFHGKISREESEQIVLIGSKTNG KFLIRARDNNGSYALCLLHE GKVLHYRIDKDKTGKLSIPEGKKFD TLWQLVEHYSYKADGLLRVLTVPCQ KIGTQGNVNFGGRPQLPGSH PATWSAGGIISRIKSYSFPKPGHRK SSPAQGNRQESTVSFNPYEPELAPW AADKGPQREALPMDTEVYES PYADPEEIRPKEVYLDRKLLTLEDK ELGSGNFGTVKKGYYQMKKVVKTVA VKILKNEANDPALKDELLAE ANVMQQLDNPYIVRMIGICEAESWM LVMEMAELGPLNKYLQQNRHVKDKN IIELVHQVSMGMKYLEESNF VHRDLAARNVLLVTQHYAKISDFGL SKALRADENYYKAQTHGKWPVKWYA PECINYYKFSSKSDVWSFGV LMWEAFSYGQKPYRGMKGSEVTAML EKGERMGCPAGCPREMYDLMNLCWT YDVENRPGFAAVELRLRNYY
  YDVVNTRTRPLEQKLISEEDLAAND ILDYKDDDDKV
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining.
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade.
• Concentration: >50 ug/mL as determined by microplate BCA method.
• Preparation: Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps.
• Protein Families: Druggable Genome, Protein Kinase
• Protein Pathways: B cell receptor signaling pathway, Fc epsilon RI signaling pathway, Fc gamma R-mediated phagocytosis, Natural killer cell mediated cytotoxicity

Gene Information

• Gene Name: SYK spleen associated tyrosine kinase [ Homo sapiens (human) ]
• Official Symbol: SYK
• Synonyms: IMD82; p72-Syk
• Gene ID: 6850
• mRNA Refseq: NM_003177.7
• Protein Refseq: NP_003168.2
• MIM: 600085
• UniProt ID: P43405