sfrp2
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  • Official Full Name
  • secreted frizzled-related protein 2
  • Background
  • This gene encodes a member of the SFRP family that contains a cysteine-rich domain homologous to the putative;Wnt-binding site of Frizzled proteins. SFRPs act as soluble modulators of Wnt signaling. Methylation of this gene is a;potential marker for the presence of colorectal cancer.
  • Synonyms
  • SFRP2; secreted frizzled-related protein 2; FRP 2; SARP1; SDF 5; SARP-1; sFRP-2; secreted apoptosis related protein 1; secreted apoptosis-related protein 1; FRP-2; SDF-5
Cat.#:SFRP2-223HTag:GST|His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human SFRP2 Protein, GST-His-tagged
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Cat.#:SFRP2-299HTag:N/A
Source (Host):NSO cellsSpecies:Human
Product nameRecombinant Human SFRP2
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Cat.#:SFRP2-509HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human secreted frizzled-related protein 2, His-tagged
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Cat.#:SFRP2-5110HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human SFRP2, His-tagged
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Cat.#:SFRP2-7655HTag:His
Source (Host):HEK293Species:Human
Product nameRecombinant Human SFRP2, His-tagged
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Cat.#:Sfrp2-223MTag:His
Source (Host):NSO cellsSpecies:Mouse
Product nameRecombinant Mouse Sfrp2, His-tagged
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Cat.#:Sfrp2-862MTag:His
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse Sfrp2, His tagged
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Cat.#:SFRP2-6337CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken SFRP2
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Cat.#:SFRP2-4716ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish SFRP2
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Cat.#:SFRP2-2851MCLTag:N/A
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse SFRP2 cell lysate
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Involved Pathway

Sfrp2 involved in several pathways and played different roles in them. We selected most pathways Sfrp2 participated on our site, such as Wnt signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with Sfrp2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Wnt signaling pathway
PRKACBA; FZD7A; NLK2; CCND2A; DKK1; PPP3CCB; LEF1; APC; PPP3CA; BTRC

Protein Function

Sfrp2 has several biochemical functions, for example, NOT G-protein coupled receptor activity, NOT Wnt-activated receptor activity, Wnt-protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by Sfrp2 itself. We selected most functions Sfrp2 had, and list some proteins which have the same functions with Sfrp2. You can find most of the proteins on our site.
Function
Related Protein
Function NOT G-protein coupled receptor activity
Related Protein SFRP1; SZL; LGR5; SFRP1B; SFRP1A; FRZB; SFRP4; LGR6; SFRP2; LGR4
Function NOT Wnt-activated receptor activity
Related Protein FRZB; SZL; SFRP2; SETD6; SFRP1; SFRP1A; SFRP1B; TSPAN12; SMO; SFRP4
Function Wnt-protein binding
Related Protein FZD7A; FZD1; SFRP2; CTHRC1; LRP5; FZD9B; Fzd4; SETD6; FZD7; FZD3
Function endopeptidase activator activity
Related Protein ADRM1; PSMD14; SFRP2; PSME2; PSME3; PSME1
Function fibronectin binding
Related Protein PLEKHA2; ITGAV; SDC4; VEGFA; LACRT; ITGA3; FBLN1; IGFBP5A; THBS1; CTSK
Function integrin binding
Related Protein ACTN2; WISP1; CTGFB; ESM1; S1PR2; ITGB6; NF2; KDR; ADAM2; ICAM1
Function metalloenzyme activator activity
Related Protein SFRP2
Function receptor agonist activity
Related Protein WNT2; WNT3A; WNT8A; WNT3; GREM1; WNT4; WNT1; SFRP2; WNT10B; NODAL

Interacting Protein

Sfrp2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Sfrp2 here. Most of them are supplied by our site. Hope this information will be useful for your research of Sfrp2.
BUB1; PFKM; CDH1; EEF1G; CTNNA1; BMPR1A; DCC; SMAD4; DBNDD2; MLH3; RAD54B

Sfrp2 Related Articles

Mastri, M; Shah, Z; et al. Secreted Frizzled-related protein 2 as a target in antifibrotic therapeutic intervention. AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY 306:C531-C539(2014).
Tsuruta, JK; Klauber-DeMore, N; et al. Ultrasound Molecular Imaging of Secreted Frizzled Related Protein-2 Expression in Murine Angiosarcoma. PLOS ONE 9:-(2014).