tbx3
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  • Official Full Name
  • T-box 3
  • Background
  • This gene is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. This protein is a transcriptional repressor and is thought to play a role in the anterior/posterior axis of the tetrapod forelimb. Mutations in this gene cause ulnar-mammary syndrome, affecting limb, apocrine gland, tooth, hair, and genital development. Alternative splicing of this gene results in three transcript variants encoding different isoforms; however, the full length nature of one variant has not been determined.
  • Synonyms
  • TBX3; T-box 3; ulnar mammary syndrome , UMS; T-box transcription factor TBX3; TBX3 ISO; XHL; T-box protein 3; bladder cancer related protein XHL; UMS; TBX3-ISO
Cat.#:TBX3-1586HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human TBX3 protein, His-tagged
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Cat.#:TBX3-29459THTag:
Source (Host):Wheat germSpecies:Human
Product nameRecombinant Human TBX3
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Cat.#:TBX3-3143HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human TBX3, GST-tagged
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Cat.#:Tbx3-1587MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Tbx3 protein, His-tagged
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Cat.#:TBX3-16532MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse TBX3 Protein
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Cat.#:Tbx3-1588RTag:His
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Tbx3 protein, His-tagged
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Cat.#:TBX3-5975RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat TBX3 Protein
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Cat.#:TBX3-4655CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken TBX3
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Cat.#:TBX3-1199HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human TBX3 293 Cell Lysate
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Involved Pathway

TBX3 involved in several pathways and played different roles in them. We selected most pathways TBX3 participated on our site, such as Signaling pathways regulating pluripotency of stem cells, which may be useful for your reference. Also, other proteins which involved in the same pathway with TBX3 were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Signaling pathways regulating pluripotency of stem cells
PIK3R1; MAPK1; FGFR3; WNT4; IL6ST; INHBA; POU5F1; ACVR1; WNT9B; PIK3CG

Protein Function

TBX3 has several biochemical functions, for example, RNA polymerase II activating transcription factor binding, RNA polymerase II core promoter proximal region sequence-specific DNA binding, RNA polymerase II transcription factor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by TBX3 itself. We selected most functions TBX3 had, and list some proteins which have the same functions with TBX3. You can find most of the proteins on our site.
Function
Related Protein
Function RNA polymerase II activating transcription factor binding
Related Protein EOMES; BHLHE40; SMAD3; HEY2; NCOR1; HIPK2; DUSP26; LDB1; SETD3; HNF4A
Function RNA polymerase II core promoter proximal region sequence-specific DNA binding
Related Protein MEF2A; NFAT5; TGIF1; RBPJB; MITFA; ZNF148; AGO1; CREB3L2; NACC2; HOXA2
Function RNA polymerase II transcription factor binding
Related Protein CHST13; ANKRD1; TBX6; MTA2; ZGLP1; TOX2; KLF4; MKX; GATA5; PITX2
Function protein binding
Related Protein CXorf40A; PEF1; DEDD; C1QTNF8; NTRK1; RSPO1; CTCF; ATXN2; PBLD; KCNIP3
Function sequence-specific DNA binding
Related Protein IRX5; ZNF238; ATF4; HMX3; ENG2A; HOXA13; BARHL1A; NR2C2; IRX4A; ENG2B
Function transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding
Related Protein HES1; TFAP2A; NR2E1; HINFP; HHEX; ZFP536; CC2D1B; KLF17; NKX3-2; SP3

Interacting Protein

TBX3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TBX3 here. Most of them are supplied by our site. Hope this information will be useful for your research of TBX3.
CA8; AES; Dlg4; TOLLIP