TCF4 Protein, transcription factor 4


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Official Full Name transcription factor 4
Background T-cell factor 3 and 4 (TCF3 and TCF4) are transcription factors of the High Mobility Group of DNA binding proteins. They are members of a family of four proteins referred to as LEF/TCF transcription factors (LEF1, TCF1, TCF3 and TCF4). These factors play crucial roles in WNT/Wingless signaling, a signal transduction cascade that directs cell differentiation. Aberrant activation of the WNT/Wingless pathway is also a root cause in the genesis of certain cancers such as colon cancer, melanoma and breast cancer. TCF4 generates transcriptionally active complexes with beta catenin in colon carcinoma cells. TCF3 appears to be expressed independently of TCF4 in the hair follicles, stomach epithelium, and keratinocytes of the skin.
Synonyms TCF4; transcription factor 4; bHLHb19; E2 2; ITF2; SEF2 1B; SL3-3 enhancer factor 2; transcription factor 4, isoform D; transcription factor 4, isoform R; immunoglobulin transcription factor 2; class B basic helix-loop-helix protein 19; E2-2; PTHS; SEF2
    • Species :
    • Human
    • Mouse
    • Rat
    • Source :
    • E.coli
    • HEK293
    • Insect Cell
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • Myc
    • DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human TCF4-1178HCL Recombinant Human TCF4 293 Cell Lysate HEK293 N/A
    Human TCF4-1179HCL Recombinant Human TCF4 293 Cell Lysate HEK293 N/A
    Human TCF4-12H Recombinant Human TCF4 Protein, MYC/DDK-tagged HEK293 Myc/DDK
    Human TCF4-29463TH Recombinant Human TCF4 protein, GST-tagged Wheat Germ GST
    Human TCF4-31H Recombinant Human TCF4 protein, His-tagged Insect Cell His
    Human TCF4-5109H Recombinant Human TCF4, His-tagged E.coli His
    Human TCF4-580H Recombinant Human TCF4 Protein, His-tagged E.coli His
    Mouse TCF4-16563M Recombinant Mouse TCF4 Protein Mammalian Cell His
    Rat TCF4-5990R Recombinant Rat TCF4 Protein Mammalian Cell His

    TCF4 involved in several pathways and played different roles in them. We selected most pathways TCF4 participated on our site, such as CDO in myogenesis, Coregulation of Androgen receptor activity, Corticotropin-releasing hormone, which may be useful for your reference. Also, other proteins which involved in the same pathway with TCF4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    CDO in myogenesis TCF3B; CDH4; CDH2; SPAG9; TCF3A; CDON; BNIP2; TCF4; MEF2B; BOC
    Coregulation of Androgen receptor activity MAK; SNURF; SVIL; KDM4C; PA2G4; ZMIZ1; CMTM2; KDM3A; CMTM2A; KDM1A
    Corticotropin-releasing hormone TCF4; JUNB; JUND; ADRBK2; CYP21A2; CRHBP; KRT1; TFAP2A; CRH; CRHR1
    Developmental Biology GPC1B; MYOD1; SPRED1; FOXH1; CDON; RHOC; WDR83; CAP1; CCNC; INSM1A
    Myogenesis CDH4; MYOG; MEF2B; SPAG9; CDON; BOC; TCF12; MEF2AA; BNIP2; TCF4
    Neural Crest Differentiation OLIG3; TFAP2A; PRTG; PHOX2B; SOX5; CTBP2; FOXD3; MIA; HEY2; DCT
    Regulation of Wnt-mediated beta catenin signaling and target gene transcription CDX1; AES; HBP1; CYR61; ZCCHC12; TLE1; KRT1; SALL4; IGF2BP1; TCF4
    Wnt Signaling Pathway NetPath TFAP2A; PAX2; MARK2; MTAP1B; SOX1; CSNK2A1P; CRYBB2; TCF4; MAP1B; BCL9

    TCF4 has several biochemical functions, for example, DNA binding, E-box binding, RNA polymerase II core promoter proximal region sequence-specific DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by TCF4 itself. We selected most functions TCF4 had, and list some proteins which have the same functions with TCF4. You can find most of the proteins on our site.

    Function Related Protein
    DNA binding KRBA2; SAP30; TP63; IRF2A; WRNIP1; NKX2.4B; GON4L; FOXA; HOMEZA; PAX6A
    E-box binding TFAP4; ASCL2; MYOG; PER1; NEUROG1; TWIST1; GATA3; TCF4; SREBF2; LMO2
    RNA polymerase II core promoter proximal region sequence-specific DNA binding MAFB; H2AFZ; MYPOP; MYOG; FOXD1; MYC; OTX2; SRF; TCF3B; TFAP2E
    TFIIB-class transcription factor binding TCF4
    bHLH transcription factor binding IKZF4; LMO2; USF2; RUNX2; USF1; FOXH1; TCF3B; TCF3; ASCL1; BHLHE40
    protein C-terminus binding STIP1; YEATS4; NPAT; MKI67; EP300; YAP1; PEX26; VGLL3; HIC2; SHANK3
    protein binding DAG1; ZNF239; CYP2S1; CD160; WT1; NCAPH; EXOSC2; FGF19; EFS; RPL10A
    protein heterodimerization activity HIST3H2A; UGT1A7; BCL2; TOP2B; WHRN; CXorf15; ADRA1B; HIST1H2BO; SNX1; CAPN2
    protein homodimerization activity SLC30A8; NACC2; HLCS; MBL1; HPGDS; GALE; MECOM; CHEK2; TERF2; ABCG1
    transcription factor activity, TFIIB-class binding TCF4
    transcription factor activity, sequence-specific DNA binding NFIL3-5; FOXG1; SOX11; HOXC4A; BUD31; E2F2; ZNF26; NOTCH1; KDM5B; GRHL2
    transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting TCF4
    transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding ONECUT3; IRF4; ETV2; NEUROD1; BCL11B; FOXK2; SOX1; GABPA; EBF3A; TCF21

    TCF4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TCF4 here. Most of them are supplied by our site. Hope this information will be useful for your research of TCF4.


    Kim, JT; Liu, CM; et al. Neurotensin, a novel target of Wnt/beta-catenin pathway, promotes growth of neuroendocrine tumor cells. INTERNATIONAL JOURNAL OF CANCER 136:1475-1481(2015).
    Sisirak, V; Ganguly, D; et al. Genetic evidence for the role of plasmacytoid dendritic cells in systemic lupus erythematosus. JOURNAL OF EXPERIMENTAL MEDICINE 211:1969-1976(2014).

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