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TCF4

  • Official Full Name

    transcription factor 4

  • Overview

    T-cell factor 3 and 4 (TCF3 and TCF4) are transcription factors of the High Mobility Group of DNA binding proteins. They are members of a family of four proteins referred to as LEF/TCF transcription factors (LEF1, TCF1, TCF3 and TCF4). These factors play crucial roles in WNT/Wingless signaling, a signal transduction cascade that directs cell differentiation. Aberrant activation of the WNT/Wingless pathway is also a root cause in the genesis of certain cancers such as colon cancer, melanoma and breast cancer. TCF4 generates transcriptionally active complexes with beta catenin in colon carcinoma cells. TCF3 appears to be expressed independently of TCF4 in the hair follicles, stomach epithelium, and keratinocytes of the skin.
  • Synonyms

    TCF4; transcription factor 4; bHLHb19; E2 2; ITF2; SEF2 1B; SL3-3 enhancer factor 2; transcription factor 4, isoform D; transcription factor 4, isoform R; immunoglobulin transcription factor 2; class B basic helix-loop-helix protein 19; E2-2; PTHS; SEF2;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Rat
  • E.coli
  • HEK293
  • HEK293T
  • Insect Cell
  • Mammalian Cell
  • Mammalian cells
  • Wheat Germ
  • Flag
  • GST
  • His
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • Myc|DDK
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human TCF4-29463TH Recombinant Human TCF4 protein, GST-tagged Wheat Germ GST
Human TCF4-5109H Recombinant Human TCF4, His-tagged E.coli His
Human TCF4-31H Recombinant Human TCF4 protein, His-tagged Insect Cell His
Human TCF4-12H Recombinant Human TCF4 Protein, MYC/DDK-tagged HEK293 Myc/DDK
Human TCF4-580H Recombinant Human TCF4 Protein, His-tagged E.coli His
Human TCF4-1178HCL Recombinant Human TCF4 293 Cell Lysate HEK293 N/A
Human TCF4-1179HCL Recombinant Human TCF4 293 Cell Lysate HEK293 N/A
Human TCF4-742HFL Recombinant Full Length Human TCF4 Protein, C-Flag-tagged Mammalian cells Flag
Human TCF4-2168H Recombinant Human TCF4 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human TCF4-30167H Recombinant Human TCF4 protein, GST-tagged E.coli GST Pro407-Glu560
Human TCF4-2168H-B Recombinant Human TCF4 Protein Pre-coupled Magnetic Beads HEK293
Mouse TCF4-16563M Recombinant Mouse TCF4 Protein Mammalian Cell His
Mouse TCF4-9081M Recombinant Mouse TCF4 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse TCF4-9081M-B Recombinant Mouse TCF4 Protein Pre-coupled Magnetic Beads HEK293
Mouse Tcf4-6340M Recombinant Mouse Tcf4 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Rat TCF4-5990R Recombinant Rat TCF4 Protein Mammalian Cell His
Rat TCF4-5649R Recombinant Rat TCF4 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat TCF4-5649R-B Recombinant Rat TCF4 Protein Pre-coupled Magnetic Beads HEK293
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Other Resource

TCF4 involved in several pathways and played different roles in them. We selected most pathways TCF4 participated on our site, such as CDO in myogenesis, Coregulation of Androgen receptor activity, Corticotropin-releasing hormone, which may be useful for your reference. Also, other proteins which involved in the same pathway with TCF4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
CDO in myogenesisMYF6;CDON;MYOG;CTNNA2;BOC;TCF4;CDH4;SPAG9;MYOD1
Coregulation of Androgen receptor activityPAWR;KDM3A;TMF1;TGFB1I1;MAK;ZMIZ1;CMTM2;CARM1;CTDSP1
Corticotropin-releasing hormoneIVL;CASP12;JUND;CRHR1;TCF4;CRH;TFAP2A;KRT14;CRHR2
Developmental BiologyWDR83;CHL1;MED16;GFRA1;SPRED2;COL6A2;DNM1;EFNA1;EPHA2
MyogenesisCDH4;MYOG;BOC;CDON;MEF2B;MYF6;TCF3B;TCF12;TCF4
Neural Crest DifferentiationMYB;MIA;CDH7;ASCL1;TFAP2A;FOXD3;DCT;DLL3;CTBP2
Regulation of Wnt-mediated beta catenin signaling and target gene transcriptionZCCHC12;TCF4;CYR61;CDX4;TLE1;IGF2BP1;TLE2;MYOG;TNIK
Wnt Signaling Pathway NetPathSOX1;SALL1;TFAP2A;NR5A1;HIPK2;TAX1BP3;CSNK2A1P;BRD7;ANKRD6

TCF4 has several biochemical functions, for example, DNA binding, E-box binding, RNA polymerase II core promoter proximal region sequence-specific DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by TCF4 itself. We selected most functions TCF4 had, and list some proteins which have the same functions with TCF4. You can find most of the proteins on our site.

Function Related Protein
DNA bindingFOXP1B;SIM2;DHARMA;NR1H5;ZNF146;TBPL1;TAF9;ZNF776;SPI1B
E-box bindingNEUROD1;TAL1;AHR;MYOG;C1orf51;TFAP4;ASCL1;PER1;TWIST1
RNA polymerase II core promoter proximal region sequence-specific DNA bindingRBPJB;NR3C1;ZNF253;KDM6A;RUNX2;TFE3A;PAX5;SOX10;GCFC2
TFIIB-class transcription factor binding
bHLH transcription factor bindingUSF2;RUNX2;ISL1;PSMD9;HAND1;TCF3;SP1;EP300;BHLHE40
protein C-terminus bindingMAPRE1;SIAH1A;BCL10;BLOC1S2A;COIL;VPS36;SHANK2;VPS4B;FIGN
protein bindingCDC20;NCL;MRPL49;ATF6;LPXN;DEDD;ZC3H12A;ELMO1;TMA16
protein heterodimerization activityRALGAPA2;NFE2L2A;SOS1;HIST2H2BE;HIST1H2BP;SLC3A1;CHRNA5;JAM2A;CXorf15
protein homodimerization activityPRDM6;CIB2;S100A6;TENM1;MBL1;NADKD1;JAM3;HIF1AN;SMAGP
transcription factor activity, TFIIB-class binding
transcription factor activity, sequence-specific DNA bindingZNF43;RBPJA;TFAP2B;HNF1B;RORB;HOXB5B;MYOG;SHOX;CSRNP2
transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific bindingELF3;PAX5;ZSCAN21;FOXJ1;TP73;ZFAT;MYB;CAMTA2;PLAG1

TCF4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TCF4 here. Most of them are supplied by our site. Hope this information will be useful for your research of TCF4.

CTNNB1

Research Area

Related articles

Kim, JT; Liu, CM; et al. Neurotensin, a novel target of Wnt/beta-catenin pathway, promotes growth of neuroendocrine tumor cells. INTERNATIONAL JOURNAL OF CANCER 136:1475-1481(2015).
Sisirak, V; Ganguly, D; et al. Genetic evidence for the role of plasmacytoid dendritic cells in systemic lupus erythematosus. JOURNAL OF EXPERIMENTAL MEDICINE 211:1969-1976(2014).
  • Q&As
  • Reviews

Q&As (5)

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How is RPPH1 related to TCF4? 07/14/2022

RPPH1 affects the expression level of TCF4 by regulating miR-326 expression.

What is the relationship between TCF4 expression and the development of malignant tumor cells? 01/02/2022

High TCF4 protein expression or increased expression positivity can significantly promote early malignant tumor cell.

What is the relationship between TCF4 and the development of ovarian cancer? 01/02/2022

High expression of TCF4 promotes ovarian cancer significantly.

Where is TCF4 predominantly expressed? 03/30/2021

TCF4 is mainly expressed in intercellular and embryonic mesenchymal tissue.

What diseases has TCF4 been associated with the study of? 10/21/2020

TCF4 is closely associated with studies of diseases such as ovarian and gastric cancer.

Customer Reviews (3)

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Reviews
08/12/2022

    Prompt delivery helped me get satisfactory experimental results in a short period of time.

    07/14/2022

      The TCF4 protein product received was as advertised, top quality and good value for money.

      10/22/2020

        The technician guided me through the process, which led to satisfactory results.

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