tcp1
Share
  • Official Full Name
  • t-complex 1
  • Background
  • T-complex protein 1 subunit alpha is a protein that in humans is encoded by the TCP1 gene.
  • Synonyms
  • TCP1; t-complex 1; T-complex protein 1 subunit alpha; CCT1; Ccta; D6S230E; tailless complex polypeptide 1; T-complex protein 1, alpha subunit; CCT-alpha; TCP-1-alpha
Cat.#:TCP1-27950THTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human TCP1, His-tagged
+Inquiry
Cat.#:TCP1-2851HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human T-complex 1, His-tagged
+Inquiry
Cat.#:TCP1-16579MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse TCP1 Protein
+Inquiry
Cat.#:TCP1-5992RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat TCP1 Protein
+Inquiry
Cat.#:TCP1-1009CTag:His
Source (Host):Mammalian CellsSpecies:Cynomolgus Monkey
Product nameRecombinant Cynomolgus TCP1 Protein, His-tagged
+Inquiry
Cat.#:TCP1-4656RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey TCP1 Protein, His-tagged
+Inquiry
Cat.#:TCP1-1547CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken TCP1
+Inquiry
Cat.#:TCP1-8829ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish TCP1
+Inquiry
Cat.#:TCP1-1169HCLTag:N/A
Source (Host):Species:Human
Product nameRecombinant Human TCP1 293 Cell Lysate
+Inquiry

Involved Pathway

TCP1 involved in several pathways and played different roles in them. We selected most pathways TCP1 participated on our site, such as Assembly of the primary cilium, Association of TriC/CCT with target proteins during biosynthesis, BBSome-mediated cargo-targeting to cilium, which may be useful for your reference. Also, other proteins which involved in the same pathway with TCP1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Assembly of the primary cilium
CLUAP1; BBS10; CCT3; BBS13; CEP290; IFT-20; TTC8; RP2; RAB3IP; MKKS
Association of TriC/CCT with target proteins during biosynthesis
CCT4; CCT6A; CCT2; KIFC3; TCP1; CCT7; FBXL5; CCT8; FBXW9; CCT3
BBSome-mediated cargo-targeting to cilium
RAB3IP; BBS10; CCT4; BBS9; SSTR3; TTC8; CCT5; BBS7; MKKS; BBS2
Cargo trafficking to the periciliary membrane
CCT8; MKKS; BBS5; PROL1; NPHP3; CNGA2; EXOC6; ARL3; CNGA5; BBS10
Chaperonin-mediated protein folding
CCT8; NOP56; FKBP9; CCT5; TCP1; FBXW9; CCT4; FBXW5; CCT7; PFDN2
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding
PFDN4; TUBB4B; CCT4; CCT3; CCT2; CCT5; TUBB4A; PFDN6; TUBA1B; TUBA3D
Folding of actin by CCT/TriC
CCT3; TCP1; CCT6A; CCT2; CCT4; CCT7; CCT5; CCT8
Formation of tubulin folding intermediates by CCT/TriC
CCT4; CCT2; TUBA1B; TUBB4A; TUBA3D; TUBB4B; CCT7; CCT8; CCT6A; CCT3

Protein Function

TCP1 has several biochemical functions, for example, ATP binding, poly(A) RNA binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by TCP1 itself. We selected most functions TCP1 had, and list some proteins which have the same functions with TCP1. You can find most of the proteins on our site.
Function
Related Protein
Function ATP binding
Related Protein CHKA; NLRP10; CIT; ACVR1BA; ACTB2; AK9; PSMC5; TTLL11; ABCG3; TXK
Function poly(A) RNA binding
Related Protein YWHAZ; PPIL4; NXF2; SR140; EXOSC9; RCC2; RIMS1; DDX41; SRPR; MRPL41
Function protein binding
Related Protein CORO1C; TMEM27; EIF4EA; ATG3; TRIM26; ACVR1; GPRC5A; NADSYN1; EFNA1; RSPH3
Function ubiquitin protein ligase binding
Related Protein FZD5; BCL2; PER3; TRAF4; MC1R; RPA3; FANCL; SLC25A5; DTX1; SCAMP3
Function unfolded protein binding
Related Protein DNAJA4; DNAJB5; PPIA; DNAJB1; DNAJB4; DNAJB8; SRSF12; CALRL2; CALR3; HSP90B1

Interacting Protein

TCP1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TCP1 here. Most of them are supplied by our site. Hope this information will be useful for your research of TCP1.
PPP2CA; PPP4C; PPP2CB; OLR1; STRN3; ILK

TCP1 Related Articles

Fijak, M; Zeller, T; et al. Autoantibodies against protein disulfide isomerase ER-60 are a diagnostic marker for low-grade testicular inflammation. HUMAN REPRODUCTION 29:2382-2392(2014).
Inoue, Y; Aizaki, H; et al. Chaperonin TRiC/CCT participates in replication of hepatitis C virus genome via interaction with the viral NS5B protein. VIROLOGY 410:38-47(2011).