thop1
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  • Official Full Name
  • thimet oligopeptidase 1
  • Background
  • Thimet oligopeptidase is an enzyme that in humans is encoded by the THOP1 gene.
  • Synonyms
  • THOP1; thimet oligopeptidase 1; thimet oligopeptidase; EC 3.4.24.15; Endopeptidase 24.15; EP24.15; MEPD_HUMAN; MP78; THOP1_HUMAN; TOP
Cat.#:THOP1-650HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human THOP1 Protein, His-tagged
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Cat.#:THOP1-888HTag:Myc|DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human THOP1 Protein, MYC/DDK-tagged
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Cat.#:THOP1-29998THTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human THOP1, His-tagged
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Cat.#:THOP1-528HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human THOP1 Protein, His-tagged
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Cat.#:Thop1-2555MTag:His
Source (Host):Baculovirus-Insect CellsSpecies:Mouse
Product nameRecombinant Mouse Thop1, His tagged
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Cat.#:THOP1-6056RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat THOP1 Protein
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Cat.#:THOP1-1464ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish THOP1
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Cat.#:THOP1-529MCLTag:N/A
Source (Host):Baculovirus-Insect CellsSpecies:Mouse
Product nameRecombinant Mouse THOP1 cell lysate
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Involved Pathway

THOP1 involved in several pathways and played different roles in them. We selected most pathways THOP1 participated on our site, such as Renin-angiotensin system, African trypanosomiasis, which may be useful for your reference. Also, other proteins which involved in the same pathway with THOP1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Renin-angiotensin system
REN; ACE; MAS1; KLK1B26; LNPEP; PREP; CTSA; KLK1B5; AGTR1B; KLK1B8
African trypanosomiasis
FAS; F2RL1; LAMA4; HBB-B1; MYD88; HBA1; ICAM1; IL18; IL12B; PRKCB

Protein Function

THOP1 has several biochemical functions, for example, metal ion binding, metalloendopeptidase activity, peptide binding. Some of the functions are cooperated with other proteins, some of the functions could acted by THOP1 itself. We selected most functions THOP1 had, and list some proteins which have the same functions with THOP1. You can find most of the proteins on our site.
Function
Related Protein
Function metal ion binding
Related Protein SAR1B; HBBE2; GIT2B; SUCLA2; CYP4A10; SMYD2; AARSD1; ZNF83; CYGB1; PHLPP1
Function metalloendopeptidase activity
Related Protein ASTL; ADAM25; MMP13; ADAM23; ADAM7; TLL1; PMPCB; ADAMDEC1; NRD1B; MMP19
Function peptide binding
Related Protein BDKRB1; GNRHR2; ERAP1; ENPEP; RPS6KB2; CCKAR; PCSK5; AVPR1A; NPFFR1L1; RNPEPL1
Function protein binding
Related Protein FAM154A; TBX6; TUT1; SRA1; SRGN; GAPDHS; ZKSCAN17; CYB5R1; CDC42EP4; CEP120

Interacting Protein

THOP1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with THOP1 here. Most of them are supplied by our site. Hope this information will be useful for your research of THOP1.
Calm1; IKBKE; STK11; MPHOSPH6; CALM1

THOP1 Related Articles

Miners, JS; Verbeek, MM; et al. Immunocapture-based fluorometric assay for the measurement of neprilysin-specific enzyme activity in brain tissue homogenates and cerebrospinal fluid. JOURNAL OF NEUROSCIENCE METHODS 167:229-236(2008).
York, IA; Bhutani, N; et al. Tripeptidyl peptidase II is the major peptidase needed to trim long antigenic precursors, but is not required for most MHC class I antigen presentation. JOURNAL OF IMMUNOLOGY 177:1434-1443(2006).