Recombinant Human THOP1 Protein (Asn451-Thr597), His tagged

• Cat.No.: THOP1-6448H
• Product Overview: Recombinant human THOP1 (Asn451-Thr597) fused with His tag was expressed in E. coli.

Specification

• Species: Human
• Source: E.coli
• Tag: His
• Protein Length: Asn451-Thr597
• Description: THOP1, also known as Thimet oligopeptidase 1, Thimet oligopeptidase, EC 3.4.24.15, or EP24.15, is a zinc (II) endopeptidase implicated in the processing of numerous physiological peptides. As an intracellular enzyme, highly expressed in the brain, kidneys and neuroendocrine tissue, THOP1 has been proposed to metabolize peptides within cells, thereby affecting antigen presentation and G protein-coupled receptor signal transduction. Its substrates is gonadotrophin-releasing hormone (GnRH), an important hypothalamic hormone that regulates the synthesis and release of oestradiol and facilitates female sexual behaviour. THOP1 against toxic effects of Abeta in the early stages of Alzheimer disease (AD) pathology, and suggest that the observed increase in THOP1 expression might be part of a compensatory defense mechanism of the brain against an increased Abeta load.
• Form: Lyophilized powder/frozen liquid
• Molecular Mass: 18.62 kDa
• Purity: > 90 % as determined by SDS-PAGE
• Notes: For research use only.
• Storage: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8 centigrade for one week. Store at -20 to -80 centigrade for twelve months from the date of receipt.
• Storage Buffer: Supplied as solution form in PBS, pH 7.5 or lyophilized from PBS, pH 7.5.
• Reconstitution: Reconstitute in sterile water for a stock solution.
• Shipping: They are shipped out with dry ice/blue ice unless customers require otherwise.

Gene Information

• Gene Name: THOP1 thimet oligopeptidase 1 [ Homo sapiens (human) ]
• Official Symbol: THOP1
• Synonyms: THOP1; thimet oligopeptidase 1; thimet oligopeptidase; endopeptidase 24.15; TOP; MP78; EP24.15; MEPD_HUMAN
• Gene ID: 7064
• mRNA Refseq: NM_003249
• Protein Refseq: NP_003240
• MIM: 601117
• UniProt ID: P52888