TIMP3 Protein, TIMP metallopeptidase inhibitor 3


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Official Full Name TIMP metallopeptidase inhibitor 3
Background This gene belongs to the TIMP gene family. The proteins encoded by this gene family are inhibitors of the matrix metalloproteinases, a group of peptidases involved in degradation of the extracellular matrix (ECM). Expression of this gene is induced in response to mitogenic stimulation and this netrin domain-containing protein is localized to the ECM. Mutations in this gene have been associated with the autosomal dominant disorder Sorsbys fundus dystrophy. [provided by RefSeq, Jul 2008]
Synonyms TIMP3; TIMP metallopeptidase inhibitor 3; SFD; K222; K222TA2; HSMRK222; metalloproteinase inhibitor 3; TIMP-3; MIG-5 protein; protein MIG-5; tissue inhibitor of metalloproteinases 3;
    • Species :
    • Cattle
    • Chicken
    • Cynomolgus Monkey
    • Human
    • Mouse
    • Rat
    • Rhesus Macaque
    • Source :
    • CHO
    • E.coli
    • HEK293
    • Mammalian Cell
    • NSO
    • Tag :
    • Fc
    • His
    • T7
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human TIMP3-001H Recombinant Human TIMP3, MIgG2a Fc-tagged CHO Fc
    Human TIMP3-002H Recombinant Human TIMP3 protein, Fc-tagged HEK293 Fc
    Human TIMP3-1064HCL Recombinant Human TIMP3 293 Cell Lysate HEK293 N/A
    Human TIMP3-2528H Recombinant Human TIMP Metallopeptidase Inhibitor 3 NSO N/A
    Human TIMP3-2529H Recombinant Human TIMP Metallopeptidase Inhibitor 3, GST-tagged E.coli His
    Human TIMP3-31151TH Recombinant Human TIMP3 N/A
    Human TIMP3-545H Recombinant Human TIMP3 protein, His & T7-tagged E.coli His/T7
    Human TIMP3-852H Recombinant Human TIMP3 protein, His-tagged E.coli His
    Mouse TIMP3-16800M Recombinant Mouse TIMP3 Protein Mammalian Cell His
    Mouse Timp3-546M Recombinant Mouse Timp3 protein, His-tagged E.coli His
    Rat Timp3-547R Recombinant Rat Timp3 protein, His-tagged E.coli His
    Cynomolgus Monkey TIMP3-1024C Recombinant Cynomolgus TIMP3 Protein, His-tagged Mammalian Cell His
    Rhesus Macaque TIMP3-4723R Recombinant Rhesus monkey TIMP3 Protein, His-tagged Mammalian Cell His
    Chicken TIMP3-7036C Recombinant Chicken TIMP3 Mammalian Cell His
    Cattle TIMP3-544C Recombinant Cattle TIMP3 protein, His & T7-tagged E.coli His/T7

    TIMP3 involved in several pathways and played different roles in them. We selected most pathways TIMP3 participated on our site, such as Proteoglycans in cancer, MicroRNAs in cancer, which may be useful for your reference. Also, other proteins which involved in the same pathway with TIMP3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Proteoglycans in cancer MDM2; ITPR1; PRKCA; WNT9B; FZD6; WNT16; VEGFA; FASLG; CAV3; AKT1
    MicroRNAs in cancer PRKCB; HDAC1; DNMT3B; CDC25A; BMI1; PIK3CA; PDGFRB; MAPK1; TP63; RHOA

    TIMP3 has several biochemical functions, for example, metal ion binding, metalloendopeptidase inhibitor activity, protease binding. Some of the functions are cooperated with other proteins, some of the functions could acted by TIMP3 itself. We selected most functions TIMP3 had, and list some proteins which have the same functions with TIMP3. You can find most of the proteins on our site.

    Function Related Protein
    metal ion binding WEE2; JAZF1; ZMYND19; FGD6; ZNF326; GALNTL6; ZYMND12; ZFP639; ZNF454; PPP4CA
    metalloendopeptidase inhibitor activity SPOCK3; TIMP1; TIMP2; TIMP3; COL4A3; TIMP2B; RECK; WFIKKN1; TIMP2A; LXN
    protease binding COMP; SRI; DVL3; CSTA; CRADD; FADD; ELANE; BCL2; MBL1; KIT
    protein binding SHOC2; NECAB3; GCNT1; PRF1; UBL4A; TPR; GLYAT; FAM125A; TSN; RABIF

    TIMP3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TIMP3 here. Most of them are supplied by our site. Hope this information will be useful for your research of TIMP3.


    Jackson, MT; Moradi, B; et al. Activation of Matrix Metalloproteinases 2, 9, and 13 by Activated Protein C in Human Osteoarthritic Cartilage Chondrocytes. ARTHRITIS & RHEUMATOLOGY 66:1525-1536(2014).
    Weizman, A; Huang, B; et al. Clinical, Serologic, and Genetic Factors Associated with Pyoderma Gangrenosum and Erythema Nodosum in Inflammatory Bowel Disease Patients. INFLAMMATORY BOWEL DISEASES 20:525-533(2014).

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