|Official Full Name||TIMP metallopeptidase inhibitor 3|
|Background||This gene belongs to the TIMP gene family. The proteins encoded by this gene family are inhibitors of the matrix metalloproteinases, a group of peptidases involved in degradation of the extracellular matrix (ECM). Expression of this gene is induced in response to mitogenic stimulation and this netrin domain-containing protein is localized to the ECM. Mutations in this gene have been associated with the autosomal dominant disorder Sorsbys fundus dystrophy. [provided by RefSeq, Jul 2008]|
|Synonyms||TIMP3; TIMP metallopeptidase inhibitor 3; SFD; K222; K222TA2; HSMRK222; metalloproteinase inhibitor 3; TIMP-3; MIG-5 protein; protein MIG-5; tissue inhibitor of metalloproteinases 3;|
|Species||Cat.#||Product name||Source (Host)||Tag||Protein Length||Price|
TIMP3 involved in several pathways and played different roles in them. We selected most pathways TIMP3 participated on our site, such as Proteoglycans in cancer, MicroRNAs in cancer, which may be useful for your reference. Also, other proteins which involved in the same pathway with TIMP3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
|Pathway Name||Pathway Related Protein|
|Proteoglycans in cancer||MDM2; ITPR1; PRKCA; WNT9B; FZD6; WNT16; VEGFA; FASLG; CAV3; AKT1|
|MicroRNAs in cancer||PRKCB; HDAC1; DNMT3B; CDC25A; BMI1; PIK3CA; PDGFRB; MAPK1; TP63; RHOA|
TIMP3 has several biochemical functions, for example, metal ion binding, metalloendopeptidase inhibitor activity, protease binding. Some of the functions are cooperated with other proteins, some of the functions could acted by TIMP3 itself. We selected most functions TIMP3 had, and list some proteins which have the same functions with TIMP3. You can find most of the proteins on our site.
|metal ion binding||WEE2; JAZF1; ZMYND19; FGD6; ZNF326; GALNTL6; ZYMND12; ZFP639; ZNF454; PPP4CA|
|metalloendopeptidase inhibitor activity||SPOCK3; TIMP1; TIMP2; TIMP3; COL4A3; TIMP2B; RECK; WFIKKN1; TIMP2A; LXN|
|protease binding||COMP; SRI; DVL3; CSTA; CRADD; FADD; ELANE; BCL2; MBL1; KIT|
|protein binding||SHOC2; NECAB3; GCNT1; PRF1; UBL4A; TPR; GLYAT; FAM125A; TSN; RABIF|
TIMP3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TIMP3 here. Most of them are supplied by our site. Hope this information will be useful for your research of TIMP3.