Active Recombinant Human TIMP3, MIgG2a Fc-tagged

• Cat.No.: TIMP3-001H
• Product Overview: The extracellular domain of human TIMP3(AAH14277.1)(Cys24-Pro211) is fused to the N-terminus of the Fc region of mouse IgG2a was expressed in CHO cell.

Specification

• Species: Human
• Source: CHO
• Tag: Fc
• Protein Length: 24-211 a.a.
• Description: This gene belongs to the TIMP gene family. The proteins encoded by this gene family are inhibitors of the matrixmetalloproteinases, a group of peptidases involved in degradation of the extracellular matrix (ECM). Expressionof this gene is induced in response to mitogenic stimulation and this netrin domain-containing protein islocalized to the ECM. Mutations in this gene have been associated with the autosomal dominant disorder Sorsby"sfundus dystrophy.
• Form: Lyophilized from 0.2μm-filtered solution in PBS.
• Bio-activity: Measured by its ability to induce alkaline phosphatase production .
• Molecular Mass: 48KDa (monomer)
• AA Sequence: Cys24-Pro211
• Endotoxin: <0.06 eu/μg="" as="" determined="" by="" lal="" test.="">
• Purity: >98%, by SDS-PAGE under reducing conditions.
• Stability: Stable for at least 1 year after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C.
• Reconstitution: Reconstitute at 100μg/ml in sterile PBS.
• Warning: Avoid freeze/thaw cycles.

Gene Information

• Gene Name: TIMP3 TIMP metallopeptidase inhibitor 3 [ Homo sapiens ]
• Official Symbol: TIMP3
• Synonyms: TIMP3; TIMP metallopeptidase inhibitor 3; SFD, tissue inhibitor of metalloproteinase 3 (Sorsby fundus dystrophy, pseudoinflammatory); metalloproteinase inhibitor 3; TIMP-3; MIG-5 protein; protein MIG-5; tissue inhibitor of metalloproteinases 3; SFD; K222; K222TA2; HSMRK222
• Gene ID: 7078
• mRNA Refseq: NM_000362
• Protein Refseq: NP_000353
• MIM: 188826
• UniProt ID: P35625
• Chromosome Location: 22q12.3
• Pathway: Endochondral Ossification, organism-specific biosystem; Matrix Metalloproteinases, organism-specific biosystem
• Function: enzyme inhibitor activity; metal ion binding; metalloendopeptidase inhibitor activity; protein binding