"TIMP3" Related Products


Recombinant Human TIMP3 protein, His-tagged

Cat.No.: TIMP3-852H
Product Overview: Recombinant Human TIMP3(Cys24-Pro211) fused with His tag at N-terminal was expressed in E. coli.
Description: This gene belongs to the TIMP gene family. The proteins encoded by this gene family are inhibitors of the matrix metalloproteinases, a group of peptidases involved in degradation of the extracellular matrix (ECM). expression of this gene is induced in response to mitogenic stimulation and this netrin domain-containing protein is localized to the ECM. Mutations in this gene have been associated with the autosomal dominant disorder Sorsby's fundus dystrophy.
Source: E. coli
Species: Human
Tag: His
Form: Lyophilized from a 0.2 µm filtered PBS solution (pH 7.4).
Molecular Mass: 23.4 kDa
Purity: Purity: >90%, as determined by SDS-PAGE under reducing conditions and visualized by Coomassie blue staining.
Applications: ELISA, Western blotting, Dot Blotting, Immunogen, Protein Array, Function Assay, etc. Before use, heat the WBC control at 95 centigrade for 5 minutes. Spin down the sample and load 5 µL per lane onto SDS-PAGE gel.
Storage: Upon arrival, the protein may be stored for 2 weeks at 4 centigrade. For long term storage, it is recommended to store at -20 centigrade or -80 centigrade in appropriate aliquots. Avoid repeated freeze-thaw cycles.
Reconstitution: Briefly spin the vial and bring the contents to the bottom prior to opening. It is recommended to reconstitute at 0.5~1.0 mg/mL with sterile deionized water or PBS.
Gene Name: TIMP3 TIMP metallopeptidase inhibitor 3 [ Homo sapiens ]
Official Symbol: TIMP3
Synonyms: TIMP3; TIMP metallopeptidase inhibitor 3; SFD, tissue inhibitor of metalloproteinase 3 (Sorsby fundus dystrophy, pseudoinflammatory); metalloproteinase inhibitor 3; TIMP-3; MIG-5 protein; protein MIG-5; tissue inhibitor of metalloproteinases 3; SFD; K222; K222TA2; HSMRK222;
Gene ID: 7078
mRNA Refseq: NM_000362
Protein Refseq: NP_000353
MIM: 188826
UniProt ID: P35625
Chromosome Location: 22q12.3
Pathway: Endochondral Ossification, organism-specific biosystem; Matrix Metalloproteinases, organism-specific biosystem;
Function: enzyme inhibitor activity; metal ion binding; metalloendopeptidase inhibitor activity; protein binding;

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Optional requirements on this protein    +Expand
C-fusion    N-fusion   Non-tagged
His    GST   Fc   Others
<1.0 eu/μg    <0.1 eu/μg   <0.01 eu/μg   Not required
Monomer Isolation    Dimer Isolation    Not required
>80% by SDS-PAGE    >90% by SDS-PAGE   >95% by SDS-PAGE   Others

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