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Official Full Name tousled-like kinase 1
Background The protein encoded by this gene is a serine/threonine kinase that may be involved in the regulation of chromatin;assembly. The encoded protein is only active when it is phosphorylated, and this phosphorylation is cell;cycle-dependent, with the maximal activity of this protein coming during S phase. The catalytic activity of this;protein is diminished by DNA damage and by blockage of DNA replication. Three transcript variants encoding different;isoforms have been found for this gene.
Synonyms TLK1; tousled-like kinase 1; serine/threonine-protein kinase tousled-like 1; KIAA0137; PKU BETA; SNARE protein kinase SNAK; serine threonine protein kinase; PKU-beta
    • Species :
    • Human
    • Mouse
    • Source :
    • E.coli
    • HEK293
    • HEK293T
    • Insect Cell
    • Sf9 Insect Cell
    • Tag :
    • GST
    • His
    • Myc/DDK
    • Myc
    • DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human TLK1-2081H Recombinant Human TLK1 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Mouse Tlk1-6449M Recombinant Mouse Tlk1 Protein, Myc/DDK-tagged HEK293T Myc/DDK
    Human TLK1-1107H Recombinant Human TLK1 Protein, MYC/DDK-tagged HEK293 Myc/DDK
    Human TLK1-1112H Recombinant Human Tousled-Like Kinase 1, GST-tagged Sf9 Insect Cell GST
    Human TLK1-1361H Recombinant Human Tousled-Like Kinase 1, GST-tagged Insect Cell GST
    Human TLK1-1497H Recombinant Human TLK1 (Active), GST-tagged Sf9 Insect Cell GST
    Human TLK1-3252H Recombinant Human TLK1, GST-tagged E.coli GST
    Human TLK1-589HCL Recombinant Human TLK1 cell lysate Insect Cell N/A
    Human TLK1-901H Recombinant Human TLK1, His & GST tagged Insect Cell His/GST

    TLK1 involved in several pathways and played different roles in them. We selected most pathways TLK1 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with TLK1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein

    TLK1 has several biochemical functions, for example, molecular_function. Some of the functions are cooperated with other proteins, some of the functions could acted by TLK1 itself. We selected most functions TLK1 had, and list some proteins which have the same functions with TLK1. You can find most of the proteins on our site.

    Function Related Protein
    molecular_function CRYGS1; TLE4; SPON1A; PWWP2A; NUDCD1; HSCB; KRTAP15; OTOL1; MS4A4D; CCDC77

    TLK1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TLK1 here. Most of them are supplied by our site. Hope this information will be useful for your research of TLK1.

    TPM3; LUZP4; Dynll1; ASF1B; YWHAE; UBE3C; pykA; ppsC; uup; ASF1A; SNAP23

    Klimovskaia, IM; Young, C; et al. Tousled-like kinases phosphorylate Asf1 to promote histone supply during DNA replication. NATURE COMMUNICATIONS 5:-(2014).
    Pascoalino, B; Dindar, G; et al. Characterization of two different Asf1 histone chaperones with distinct cellular localizations and functions in Trypanosoma brucei. NUCLEIC ACIDS RESEARCH 42:2906-2918(2014).

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