tlr2
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  • Official Full Name
  • toll-like receptor 2
  • Background
  • The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This gene is expressed most abundantly in peripheral blood leukocytes, and mediates host response to Gram-positive bacteria and yeast via stimulation of NF-kappaB. [provided by RefSeq, Jul 2008]
  • Synonyms
  • TLR2; toll-like receptor 2; TIL4; CD282; toll/interleukin 1 receptor-like 4; toll/interleukin-1 receptor-like protein 4
Cat.#:TLR2-1106HTag:Myc|DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human TLR2 Protein, MYC/DDK-tagged
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Cat.#:TLR2-182HTag:His
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human TLR2 Protein, His-tagged
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Cat.#:TLR2-30423THTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human TLR2 protein, GST-tagged
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Cat.#:TLR2-3258HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human TLR2, GST-tagged
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Cat.#:TLR2-529HTag:His
Source (Host):NSO CellsSpecies:Human
Product nameRecombinant Human TLR2 Protein, His-tagged
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Cat.#:TLR2-744HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human TLR2 protein, His-tagged
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Cat.#:TLR2-745HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human TLR2 protein, His-tagged
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Cat.#:Tlr2-7396MTag:His
Source (Host):Baculovirus-Insect CellsSpecies:Mouse
Product nameRecombinant Mouse Tlr2, His tagged
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Cat.#:Tlr2-746MTag:His|T7
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Tlr2 protein, His & T7-tagged
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Cat.#:Tlr2-747RTag:His|GST
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Tlr2 protein, His & GST-tagged
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Cat.#:Tlr2-7498RTag:His
Source (Host):Baculovirus-Insect CellsSpecies:Rat
Product nameRecombinant Rat Tlr2, His tagged
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Cat.#:TLR2-1667RTag:N/A
Source (Host):HEK293Species:Rhesus monkey
Product nameRecombinant Rhesus Monkey TLR2 Protein
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Cat.#:TLR2-1668RTag:hIgG1
Source (Host):HEK293Species:Rhesus monkey
Product nameRecombinant Rhesus Monkey TLR2 Protein, hIgG1-tagged
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Cat.#:TLR2-1669RTag:hIgG4
Source (Host):HEK293Species:Rhesus monkey
Product nameRecombinant Rhesus Monkey TLR2 Protein, hIgG4-tagged
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Cat.#:TLR2-4731RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey TLR2 Protein, His-tagged
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Cat.#:TLR2-12078ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish TLR2
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Cat.#:TLR2-439HCLTag:N/A
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human TLR2 cell lysate
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Cat.#:TLR2-001MCLTag:N/A
Source (Host):Baculovirus-Insect CellsSpecies:Mouse
Product nameRecombinant Mouse TLR2 cell lysate
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Cat.#:TLR2-001RCLTag:N/A
Source (Host):Baculovirus-Insect CellsSpecies:Rat
Product nameRecombinant Rat TLR2 cell lysate
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Involved Pathway

TLR2 involved in several pathways and played different roles in them. We selected most pathways TLR2 participated on our site, such as Phagosome, PIK-Akt signaling pathway, Toll-like receptor signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with TLR2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Phagosome
ITGB2; TUBA1C; RAB7A; ATP6V1BA; ATPV0E2; ATP6V1D; BMA2; ATP6V0A1A; SCARB1; ATP6V1AA
PIK-Akt signaling pathway
PRKCA; FGF14; ANGPT1; GNGT1; GNG2; IFNA14; IL2RA; AKT2; MAP2K1; VEGFA
Toll-like receptor signaling pathway
MAPK8; TNF; MAP2K4A; CD40; MAPK3; CCL4L1; LY96; TBK1; STAT1A; MAP3K7
Legionellosis
Casp3; APAF1; SEC22B; RAB1A; EEF1A1; NAIP7; BNIP3; CASP9; SAR1B; TNF
Leishmaniasis
IL1A; IRAK4; HLA-DPB1; FCGR4; PTPN6; HLA-DRB1; FCGR1; FCGR3B; HLA-DRB4; TNF
Chagas disease (American trypanosomiasis)
IL-8; PIK3R3; Fasl; C1QB; PPP2R2C; PIK3CG; IRAK1; TNF; CD3D; MAPK9
Malaria
IL1B; KLRC4-KLRK1; HBA2; TLR4; GYPC; IL6; CCL2; Ccl12; HBA-A2; ICAM1
Toxoplasmosis
LAMA1; IKBKG; HSPA6; Casp3; AKT1; GNAO1; CASP9; LAMC1; RELA; PIK3CB
Amoebiasis
PIK3CB; SERPINB2; CXCL8; LAMB1; LAMA1; LAMC1; LAMC2; TGFB2; COL24A1; PIK3CG
Tuberculosis
CD209C; HLA-DPB1; RFXANK; MAPK10; SYK; APAF1; IFNA4; PPP3CC; Ifna15; ATP6V0A1
Hepatitis B
EP300; TP53; SRC; STAT2; PIK3R3; SMAD4; PIK3R5; HRAS; IFNA7; CCNA2
Measles
CD209; STAT2; IRAK1; IFNA5; TNFRSF10D; NFKBIB; IL2RB; PIK3CD; IFNA14; TBK1
Herpes simplex infection
TRAF3; MAVS; OAS1; CD74A; FOS; JAK2A; IL1B; CLOCKB; IL15; PER3
Proteoglycans in cancer
RRAS; CBL; MAP2K1; CAV2; FGFR1; ERBB4; ITGB3; PIK3CD; IGF1; WNT5B
Inflammatory bowel disease (IBD)
HLA-DMA; IL18; IL13; TBX21; HLA-DRB3; HLA-DOA; IL6; HLA-DQA2; IL23R; TLR2
Rheumatoid arthritis
ATP6V0E1; TGFB2; H2-AA; HLA-DRB5; GM-CSF; HLA-DOA; ATP6V1A; ATP6V1B1; H2-AB1; HLA-DRA

Protein Function

TLR2 has several biochemical functions, for example, Toll-like receptor binding, diacyl lipopeptide binding, lipopolysaccharide binding. Some of the functions are cooperated with other proteins, some of the functions could acted by TLR2 itself. We selected most functions TLR2 had, and list some proteins which have the same functions with TLR2. You can find most of the proteins on our site.
Function
Related Protein
Function Toll-like receptor binding
Related Protein TLR2; TOLLIP
Function diacyl lipopeptide binding
Related Protein TLR2; TLR6
Function lipopolysaccharide binding
Related Protein CD14; P2RX7; TLR2; SPON2; CATHL3; PTAFR; BPIFC; SCARB1; HMGB1; LBP
Function lipopolysaccharide receptor activity
Related Protein PTAFR; LY96; TLR4; SCARB1; TLR2
Function lipoteichoic acid binding
Related Protein TLR2; TREM2; LBP; CD14; CD6
Function peptidoglycan binding
Related Protein PGLYRP3; NOD1; NLRP3; TLR2; RNASE7; TREM2; PGLYRP2; PGLYRP1; PGLYRP4
Function protein binding
Related Protein FAM167A; APOH; HIST2H4A; ALAS2; NCS1; MSH5; PSMD3; CABP5; USH2A; PPP1R9A
Function protein heterodimerization activity
Related Protein PPP2R1A; SYT14; BTBD11A; HIST1H4E; UBA2; LIFR; HIST1H2BP; BAK1; ADIPOR1; NFYBB
Function receptor activity
Related Protein ITGB1A; SELS; ANXA2R; SLC40A1; ADIPOR2; CSF2RB; RAMP3; CLEC4M; TNFRSF10B; CD200
Function signaling pattern recognition receptor activity
Related Protein MARCO; COLEC12; FCN1; CLEC7A; TRIM5; TLR2; DMBT1
Function transmembrane signaling receptor activity
Related Protein OR4C13; CD3D; GP6; OR12D3; CD69; CD27; TLR18; BAI2; MPL; OR12D2
Function triacyl lipopeptide binding
Related Protein TLR2

Interacting Protein

TLR2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TLR2 here. Most of them are supplied by our site. Hope this information will be useful for your research of TLR2.
PAUF; EGFR; MYD88; BGN; PIK3R1; ppe68; PE35; ATG16L1; TGFB1; FBP1; TMOD1; AKT1; STX17; MAP2K1; SMAD1; ANP32B

TLR2 Related Articles

Ammerdorffer, A; Schoffelen, T; et al. Recognition of Coxiella burnetii by Toll-like Receptors and Nucleotide-Binding Oligomerization Domain-like Receptors. JOURNAL OF INFECTIOUS DISEASES 211:978-987(2015).
Zhang, XJ; Xu, J; et al. Expression and function of Toll-like receptors in peripheral blood mononuclear cells from patients with ovarian cancer. CANCER IMMUNOLOGY IMMUNOTHERAPY 64:275-286(2015).