Recombinant Human TLR2 Protein, DYKDDDDK-tagged

• Cat.No.: TLR2-151H
• Product Overview: Recombinant Human toll like receptor 2(TLR2) protein, transcript variant 3(NM_003264), with a DYKDDDDK tag, was expressed in human cells.

Specification

• Description: The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. This protein is a cell-surface protein that can form heterodimers with other TLR family members to recognize conserved molecules derived from microorganisms known as pathogen-associated molecular patterns (PAMPs). Activation of TLRs by PAMPs leads to an up-regulation of signaling pathways to modulate the host's inflammatory response. This gene is also thought to promote apoptosis in response to bacterial lipoproteins. This gene has been implicated in the pathogenesis of several autoimmune diseases. Alternative splicing results in multiple transcript variants.
• Source: Human Cells
• Species: Human
• Tag: DYKDDDDK
• Form: Purified protein formulated in a sterile solution of TBS buffer, pH7.175, without any preservatives.
• Molecular Mass: 89.7 kDa
• Endotoxin: Endotoxin level is < 0.1 ng/µg of protein (<1EU /µg)
• Purity: >90% by SDS-PAGE gel and Coomassie Blue staining
• Applications: Antigens, Western, ELISA and other in vitro binding or in vivo functional assays, and protein-protein interaction studies.

Gene Information

• Gene Name: TLR2 toll-like receptor 2 [ Homo sapiens ]
• Official Symbol: TLR2
• Synonyms: TLR2; toll-like receptor 2; CD282; TIL4; toll/interleukin 1 receptor-like 4; toll/interleukin-1 receptor-like protein 4
• Gene ID: 7097
• mRNA Refseq: NM_003264
• Protein Refseq: NP_003255
• MIM: 603028
• UniProt ID: O60603