Recombinant Full Length Human TLR2 Protein, C-Flag-tagged

• Cat.No.: TLR2-1095HFL
• Product Overview: Recombinant Full Length Human TLR2 Protein, fused to Flag-tag at C-terminus, was expressed in Mammalian cells.

Specification

• Description: The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. This protein is a cell-surface protein that can form heterodimers with other TLR family members to recognize conserved molecules derived from microorganisms known as pathogen-associated molecular patterns (PAMPs). Activation of TLRs by PAMPs leads to an up-regulation of signaling pathways to modulate the host's inflammatory response. This gene is also thought to promote apoptosis in response to bacterial lipoproteins. This gene has been implicated in the pathogenesis of several autoimmune diseases. Alternative splicing results in multiple transcript variants.
• Source: Mammalian cells
• Species: Human
• Tag: Flag
• Form: 25 mM Tris HCl, pH 7.3, 100 mM glycine, 10% glycerol.
• Molecular Mass: 89.7 kDa
• AA Sequence: MPHTLWMVWVLGVIISLSKEESSNQ ASLSCDRNGICKGSSGSLNSIPSGL TEAVKSLDLSNNRITYISNS DLQRCVNLQALVLTSNGINTIEEDS FSSLGSLEHLDLSYNYLSNLSSSWF KPLSSLTFLNLLGNPYKTLG ETSLFSHLTKLQILRVGNMDTFTKI QRKDFAGLTFLEELEIDASDLQSYE PKSLKSIQNVSHLILHMKQH ILLLEIFVDVTSSVECLELRDTDLD TFHFSELSTGETNSLIKKFTFRNVK ITDESLFQVMKLLNQISGLL ELEFDDCTLNGVGNFRASDNDRVID PGKVETLTIRRLHIPRFYLFYDLST LYSLTERVKRITVENSKVFL VPCLLSQHLKSLEYLDLSENLMVEE YLKNSACEDAWPSLQTLILRQNHLA SLEKTGETLLTLKNLTNIDI SKNSFHSMPETCQWPEKMKYLNLSS TRIHSVTGCIPKTLEILDVSNNNLN LFSLNLPQLKELYISRNKLM TLPDASLLPMLLVLKISRNAITTFS KEQLDSFHTLKTLEAGGNNFICSCE FLSFTQEQQALAKVLIDWPA NYLCDSPSHVRGQQVQDVRLSVSEC HRTALVSGMCCALFLLILLTGVLCH RFHGLWYMKMMWAWLQAKRK PRKAPSRNICYDAFVSYSERDAYWV ENLMVQELENFNPPFKLCLHKRDFI PGKWIIDNIIDSIEKSHKTV FVLSENFVKSEWCKYELDFSHFRLF DENNDAAILILLEPIEKKAIPQRFC KLRKIMNTKTYLEWPMDEAQ
  REGFWVNLRAAIKSTRTRPLEQKLI SEEDLAANDILDYKDDDDKV
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining.
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade.
• Concentration: >50 ug/mL as determined by microplate BCA method.
• Preparation: Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps.
• Protein Families: Druggable Genome, Transmembrane
• Protein Pathways: Toll-like receptor signaling pathway

Gene Information

• Gene Name: TLR2 toll like receptor 2 [ Homo sapiens (human) ]
• Official Symbol: TLR2
• Synonyms: TIL4; CD282
• Gene ID: 7097
• mRNA Refseq: NM_003264.5
• Protein Refseq: NP_003255.2
• MIM: 603028
• UniProt ID: O60603