| Official Full Name | tumor necrosis factor, alpha-induced protein 6 |
| Background | The protein encoded by this gene is a secretory protein that contains a hyaluronan-binding domain, and thus is a member of the hyaluronan-binding protein family. The hyaluronan-binding domain is known to be involved in extracellular matrix stability and cell migration. This protein has been shown to form a stable complex with inter-alpha-inhibitor (I alpha I), and thus enhance the serine protease inhibitory activity of I alpha I, which is important in the protease network associated with inflammation. This gene can be induced by proinflammatory cytokines such as tumor necrosis factor alpha and interleukin-1. Enhanced levels of this protein are found in the synovial fluid of patients with osteoarthritis and rheumatoid arthritis. |
| Synonyms | TNFAIP6; tumor necrosis factor, alpha-induced protein 6; tumor necrosis factor-inducible gene 6 protein; TSG 6; TSG6; Hyaluronate binding protein; TNF stimulated gene 6 protein; TNFAIP 6; Tumor necrosis factoralpha induced protein 6; Tumor necrosis factor alpha induced protein 6; Tumor necrosis factor stimulated gene 6 protein; OTTHUMP00000162710; TNF alpha-induced protein 6; hyaluronate-binding protein; TNF-stimulated gene 6 protein; tumor necrosis factor alpha-inducible protein 6; tumor necrosis factor-stimulated gene-6 protein; TSG-6 |
| Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
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TNFAIP6 involved in several pathways and played different roles in them. We selected most pathways TNFAIP6 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with TNFAIP6 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
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TNFAIP6 has several biochemical functions, for example, hyaluronic acid binding. Some of the functions are cooperated with other proteins, some of the functions could acted by TNFAIP6 itself. We selected most functions TNFAIP6 had, and list some proteins which have the same functions with TNFAIP6. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| hyaluronic acid binding | HAPLN3; BCAN; HYAL2; NCAN; VCAN; HAPLN1A; LAYN; IMPG2; LYVE1; VCANB |
TNFAIP6 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TNFAIP6 here. Most of them are supplied by our site. Hope this information will be useful for your research of TNFAIP6.
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