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Official Full Name tumor necrosis factor, alpha-induced protein 6
Background The protein encoded by this gene is a secretory protein that contains a hyaluronan-binding domain, and thus is a member of the hyaluronan-binding protein family. The hyaluronan-binding domain is known to be involved in extracellular matrix stability and cell migration. This protein has been shown to form a stable complex with inter-alpha-inhibitor (I alpha I), and thus enhance the serine protease inhibitory activity of I alpha I, which is important in the protease network associated with inflammation. This gene can be induced by proinflammatory cytokines such as tumor necrosis factor alpha and interleukin-1. Enhanced levels of this protein are found in the synovial fluid of patients with osteoarthritis and rheumatoid arthritis.
Synonyms TNFAIP6; tumor necrosis factor, alpha-induced protein 6; tumor necrosis factor-inducible gene 6 protein; TSG 6; TSG6; Hyaluronate binding protein; TNF stimulated gene 6 protein; TNFAIP 6; Tumor necrosis factoralpha induced protein 6; Tumor necrosis factor alpha induced protein 6; Tumor necrosis factor stimulated gene 6 protein; OTTHUMP00000162710; TNF alpha-induced protein 6; hyaluronate-binding protein; TNF-stimulated gene 6 protein; tumor necrosis factor alpha-inducible protein 6; tumor necrosis factor-stimulated gene-6 protein; TSG-6
    • Species :
    • Chicken
    • Human
    • Mouse
    • Rhesus Macaque
    • Zebrafish
    • Source :
    • E. coli
    • E.coli
    • HEK293
    • Mammalian Cell
    • NS0
    • Wheat Germ
    • Tag :
    • GST
    • His
    • T7
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human TNFAIP6-3004H Recombinant Human Tumor Necrosis Factor, Alpha-Induced Protein 6, His-tagged E.coli His
    Human TNFAIP6-3005H Recombinant Human TNFAIP6 protein, GST-tagged Wheat Germ GST
    Human TNFAIP6-3315H Recombinant Human TNFAIP6, His-tagged E.coli His
    Human TNFAIP6-42H Recombinant Human TNFAIP6 protein, His-tagged NS0 His
    Human TNFAIP6-896HCL Recombinant Human TNFAIP6 293 Cell Lysate HEK293 N/A
    Mouse Tnfaip6-1417M Recombinant Mouse Tnfaip6 protein, His & T7-tagged E.coli His/T7
    Mouse TNFAIP6-17146M Recombinant Mouse TNFAIP6 Protein Mammalian Cell His
    Mouse TNFAIP6-25M Recombinant Mouse TNFAIP6 Protein, His-tagged E. coli His
    Mouse Tnfaip6-916M Recombinant Mouse Tnfaip6 Protein, His-tagged NS0 His
    Rhesus Macaque TNFAIP6-4863R Recombinant Rhesus monkey TNFAIP6 Protein, His-tagged Mammalian Cell His
    Chicken TNFAIP6-3306C Recombinant Chicken TNFAIP6 Mammalian Cell His
    Zebrafish TNFAIP6-3730Z Recombinant Zebrafish TNFAIP6 Mammalian Cell His

    TNFAIP6 involved in several pathways and played different roles in them. We selected most pathways TNFAIP6 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with TNFAIP6 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein

    TNFAIP6 has several biochemical functions, for example, hyaluronic acid binding. Some of the functions are cooperated with other proteins, some of the functions could acted by TNFAIP6 itself. We selected most functions TNFAIP6 had, and list some proteins which have the same functions with TNFAIP6. You can find most of the proteins on our site.

    Function Related Protein
    hyaluronic acid binding HAPLN3; BCAN; HYAL2; NCAN; VCAN; HAPLN1A; LAYN; IMPG2; LYVE1; VCANB

    TNFAIP6 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TNFAIP6 here. Most of them are supplied by our site. Hope this information will be useful for your research of TNFAIP6.

    Jang, YJ; Park, JI; et al. Cumulus Cell-Expressed Type I Interferons Induce Cumulus Expansion in Mice. BIOLOGY OF REPRODUCTION 92:-(2015).
    Anderson, RA; Bayne, RAL; et al. Brain-derived neurotrophic factor is a regulator of human oocyte maturation and early embryo development. FERTILITY AND STERILITY 93:1394-1406(2010).
    Nagyova, E; Camaioni, A; et al. Synthesis of tumor necrosis factor alpha-induced protein 6 in porcine preovulatory follicles: A study with A38 antibody. BIOLOGY OF REPRODUCTION 78:903-909(2008).

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