tp53bp1
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  • Official Full Name
  • tumor protein p53 binding protein 1
  • Background
  • May have a role in checkpoint signaling during mitosis. Enhances TP53-mediated transcriptional activation. Plays a role in the response to DNA damage.
  • Synonyms
  • TP53BP1; tumor protein p53 binding protein 1; p202; 53BP1; tumor suppressor p53-binding protein 1; p53BP1; p53-binding protein 1; tumor protein 53-binding protein, 1; tumor protein p53-binding protein, 1;
Cat.#:TP53BP1-2302HTag:Myc|DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human TP53BP1 Protein, MYC/DDK-tagged
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Cat.#:TP53BP1-641HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human TP53BP1 Protein, His-tagged
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Cat.#:TP53BP1-15HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human TP53BP1, GST-tagged
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Cat.#:TP53BP1-26025THTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human TP53BP1, His-tagged
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Cat.#:TP53BP1-5029ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish TP53BP1
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Involved Pathway

TP53BP1 involved in several pathways and played different roles in them. We selected most pathways TP53BP1 participated on our site, such as Cell Cycle, Cell Cycle Checkpoints, DNA Double Strand Break Response, which may be useful for your reference. Also, other proteins which involved in the same pathway with TP53BP1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Cell Cycle
GADD45AB; CENPP; CETN2; BRE; SPO11; NEDD1; FGFR1OP; MAD2L2; WAPAL; SFN
Cell Cycle Checkpoints
RAD1; BRCC3; HIST3H2BB; CDK2; UBE2V2; UIMC1; THRSP; DBF4; MCM10; HTATIP
DNA Double Strand Break Response
EYA4; EYA3; FAM175A; TP53BP1; KDM4B; BABAM1; UIMC1; BAZ1B; RNF168; BRE
DNA Double-Strand Break Repair
UIMC1; GEN1; BRCC3; FAM175A; TOPBP1; PPP4R2B; TP53BP1; RAD9A; PPP4CB; PPP4R2A
DNA Repair
COPS7B; RAD9B; INO80C; FAM175A; EME2; PPP4R2; FUZ; TDP1; RAD9A; NFRKB
G2/M Checkpoints
BARD1; TP53BP1; RAD1; HUS1; RAD9B; RAD9; RNF168; FAM175A; THRSP; RAD17
G2/M DNA damage checkpoint
RNF168; BABAM1; BARD1; TP53BP1; BRE; BRCC3; FAM175A; UIMC1; THRSP
HDR through Homologous Recombination (HR) or Single Strand Annealing (SSA)
RBBP8; PPP4CA; TP53BP1; RAD51AP1; EME2; HUS1; PPP4R2A; PPP4R2; TIPIN; RTEL1

Protein Function

TP53BP1 has several biochemical functions, for example, RNA polymerase II activating transcription factor binding, RNA polymerase II transcription cofactor activity, damaged DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by TP53BP1 itself. We selected most functions TP53BP1 had, and list some proteins which have the same functions with TP53BP1. You can find most of the proteins on our site.
Function
Related Protein
Function RNA polymerase II activating transcription factor binding
Related Protein EGR2; PITX2; POU1F1; IFI27; SMAD3; ISL1; NHLH2; NEUROD1; TBX20; CTNNB1
Function RNA polymerase II transcription cofactor activity
Related Protein MED31; MED4; MED13; NKX2-5; MED22; MED11; RBM14; MED14; MED15; TDG
Function damaged DNA binding
Related Protein ERCC1; TRP63; RAD23B; XPA; XRCC5; HMGB1; RPA2; POLK; POLI; POLH
Function methylated histone binding
Related Protein SUZ12; MSL3; WDR92; RBBP5; CHD8; TP53BP1; CBX4; CBX7; JHDM1D; RAG2
Function p53 binding
Related Protein GSK3B; PSME3; TP63; ZNF385D; TAF3; TRIM24; TRIM29; TAF1; BLM; SIRT1
Function protein binding
Related Protein EPHA4; ADI1; DNAJC28; PDIA2; RPL39L; TBCEL; GTSE1; BLOC1S3; RBL1; ERC2
Function telomeric DNA binding
Related Protein SMG6; TP53BP1; TERT; NCL; TEN1; CDAN1; TERF1; OBFC1; TERFA; HNRNPD

Interacting Protein

TP53BP1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TP53BP1 here. Most of them are supplied by our site. Hope this information will be useful for your research of TP53BP1.
H2AFX; HIST2H4B; PAXIP1; HIST1H3D