traf3
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  • Official Full Name
  • TNF receptor-associated factor 3
  • Background
  • The protein encoded by this gene is a member of the TNF receptor associated factor (TRAF) protein family. TRAF proteins associate with, and mediate the signal transduction from, members of the TNF receptor (TNFR) superfamily. This protein participates in the signal transduction of CD40, a TNFR family member important for the activation of the immune response. This protein is found to be a critical component of the lymphotoxin-beta receptor (LTbetaR) signaling complex, which induces NF-kappaB activation and cell death initiated by LTbeta ligation. Epstein-Barr virus encoded latent infection membrane protein-1 (LMP1) can interact with this and several other members of the TRAF family, which may be essential for the oncogenic effects of LMP1. Several alternatively spliced transcript variants encoding three distinct isoforms have been reported.
  • Synonyms
  • TRAF3; TNF receptor-associated factor 3; LAP1; CAP-1; CRAF1; CD40bp; CD40 binding protein; CD40 associated protein 1; LMP1-associated protein 1; CD40 receptor associated factor 1; CAP 1; CD40-binding protein; LAP 1; MIPT3; TRAF3_HUMAN
Cat.#:TRAF3-3384HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human TRAF3, GST-tagged
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Cat.#:TRAF3-3385HTag:GST
Source (Host):Wheat germSpecies:Human
Product nameRecombinant Human TRAF3, GST-tagged
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Cat.#:TRAF3-3386HTag:GST
Source (Host):Wheat germSpecies:Human
Product nameRecombinant Human TRAF3, GST-tagged
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Cat.#:TRAF3-3387HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human TRAF3, MYC/DDK-tagged
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Cat.#:TRAF3-954ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish TRAF3
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Cat.#:TRAF3-822HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human TRAF3 293 Cell Lysate
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Cat.#:TRAF3-823HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human TRAF3 293 Cell Lysate
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Involved Pathway

TRAF3 involved in several pathways and played different roles in them. We selected most pathways TRAF3 participated on our site, such as NF-kappa B signaling pathway, Toll-like receptor signaling pathway, RIG-I-like receptor signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with TRAF3 were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
NF-kappa B signaling pathway
BCL2; BIRC3; ERC1; GM1987; PIAS4; MAP3K7IP3; LY96; CCL4L1; ICAM1; LRDD
Toll-like receptor signaling pathway
IFNA3; TLR1; TICAM2; RAC1A; MAP2K4B; MAPK8B; CCL3L1; IRAK1; MAPK1; CXCL9
RIG-I-like receptor signaling pathway
TRAF6; MAVS; RNF125; IFNA12; DHX58; IL12A; IFNE; IFNA16; IFNK; MAPK13
TNF signaling pathway
MAPK10; CREB3L2; MAP2K3; CXCL3; MAP2K4; TNFRSF1B; CFLAR; PIK3R3; AKT2; MAP3K7
Hepatitis C
MAVS; EIF2AK2; PIK3R3; IFNA6; OAS2; PIK3CD; IKBKE; OCLN; CD81; ARAF
Herpes simplex infection
IFNB; SRSF7B; PPP1CC; SRSF1B; IL15; NFKBIAB; IL12B; H2-Q10; CSNK2A2; STAT1
Epstein-Barr virus infection
HDAC4; RELB; MAP3K7; IKBKB; HDAC1; PIK3CG; PSMC6; MAPK12; EIF2AK4; RBPJ
Pathways in cancer
RXRB; BRAF; ARAF; APC; STK4; BRCA2; FGF14; LPAR5; RXRG; GNGT1
Viral carcinogenesis
HLA-G; VAC14; HDAC7; SNW1; YWHAG; HIST1H4B; RAC1; CREB3L3; HIST1H2BN; SKP2
Small cell lung cancer
PIK3CD; CASP9; CYCS; BIRC7; PIK3R2; MAX; PTEN; NOS2; BCL2; NFKB1

Protein Function

TRAF3 has several biochemical functions, for example, ligase activity, protein binding, protein kinase binding. Some of the functions are cooperated with other proteins, some of the functions could acted by TRAF3 itself. We selected most functions TRAF3 had, and list some proteins which have the same functions with TRAF3. You can find most of the proteins on our site.
Function
Related Protein
Function ligase activity
Related Protein MARCH10; GLULB; RNF115; TRIM2; PELI1; RNF31; GLULC; NEURL1B; ZNRF1; RNF168
Function protein binding
Related Protein TFAP2B; LGI4; DIS3; PPP1R15B; CEP120; LENG1; SPINK2; PRKRIP1; RBBP7; PNKP
Function protein kinase binding
Related Protein TBC1D14; EEF1A2; AKAP7; RAD9; GDF3; SQSTM1; LAX1; CACNB2; EEF1A1; TRAF2
Function protein phosphatase binding
Related Protein PPP6R1; DRD1A; KCNN4; MAPK14; SNX3; AP3B1; CDC27; TP53; SHOC2; SKAP1
Function signal transducer activity
Related Protein APOL3; OR115-6; OLFCG1; CELSR1; PTH1RA; CBL; TAAR12B; MRGPRB8; TRHR2; TAS2R124
Function thioesterase binding
Related Protein TRAF2; TRAF4; CALM1; TRAF3; TRAF6; RAC1; ADRA2A; TRAF1; TRAF5; CALM
Function tumor necrosis factor receptor binding
Related Protein ERAP1; TNFB; TRAF2; CD70; TNFSF10; TNFSF10L4; TNFSF8; TRAF6; TRAF1; TNFSF4
Function ubiquitin protein ligase binding
Related Protein SMAD3; DTX1; USP13; TUBA1B; GPI1; TRIB2; UBE2KB; JKAMP; UBE2NB; FZD5
Function ubiquitin-protein transferase activity
Related Protein FBXO25; UBE2B; MALT1; ANAPC4; TRIM56; WWP2; WDSUB1; FBXW2; UBE2D4; ZYG11B
Function zinc ion binding
Related Protein BAZ2B; ZNRF2A; LMX1A; PDLIM4; FBXO40; PDLIM3A; FHL1A; BAZ1A; PHF11; TRIM46

Interacting Protein

TRAF3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TRAF3 here. Most of them are supplied by our site. Hope this information will be useful for your research of TRAF3.
TANK; TRAF3IP1; RIPK2; CD40

TRAF3 Related Articles

Chang, JH; Hu, HB; et al. TRAF3 regulates the effector function of regulatory T cells and humoral immune responses. JOURNAL OF EXPERIMENTAL MEDICINE 211:137-151(2014).
Xu, HY; He, XZ; et al. miR-338-5p indirectly regulate BAFF signal by targeting TRAF3 during renal allograft antibody-mediated rejection. JOURNAL OF IMMUNOLOGY 190:-(2013).