TRAF3
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Official Full Name
TNF receptor-associated factor 3
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Overview
The protein encoded by this gene is a member of the TNF receptor associated factor (TRAF) protein family. TRAF proteins associate with, and mediate the signal transduction from, members of the TNF receptor (TNFR) superfamily. This protein participates in the signal transduction of CD40, a TNFR family member important for the activation of the immune response. This protein is found to be a critical component of the lymphotoxin-beta receptor (LTbetaR) signaling complex, which induces NF-kappaB activation and cell death initiated by LTbeta ligation. Epstein-Barr virus encoded latent infection membrane protein-1 (LMP1) can interact with this and several other members of the TRAF family, which may be essential for the oncogenic effects of LMP1. Several alternatively spliced transcript variants encoding three distinct isoforms have been reported. -
Synonyms
TRAF3; TNF receptor-associated factor 3; LAP1; CAP-1; CRAF1; CD40bp; CD40 binding protein; CD40 associated protein 1; LMP1-associated protein 1; CD40 receptor associated factor 1; CAP 1; CD40-binding protein; LAP 1; MIPT3; TRAF3_HUMAN;
- Recombinant Proteins
- Cell & Tissue Lysates
- Human
- Mouse
- Zebrafish
- E.coli
- HEK293
- HEK293T
- In Vitro Cell Free System
- Mamanlian cells
- Mammalian Cell
- Wheat Germ
- Flag
- GST
- His
- Myc
- DDK
- Myc|DDK
- N/A
- N
Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
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Human | TRAF3-3385H | Recombinant Human TRAF3, GST-tagged | Wheat Germ | GST | ||
Human | TRAF3-3384H | Recombinant Human TRAF3, GST-tagged | E.coli | GST | 6-351aa | |
Human | TRAF3-3386H | Recombinant Human TRAF3, GST-tagged | Wheat Germ | GST | ||
Human | TRAF3-3387H | Recombinant Human TRAF3, MYC/DDK-tagged | HEK293 | Myc/DDK | ||
Human | TRAF3-823HCL | Recombinant Human TRAF3 293 Cell Lysate | HEK293 | N/A | ||
Human | TRAF3-822HCL | Recombinant Human TRAF3 293 Cell Lysate | HEK293 | N/A | ||
Human | TRAF3-5407HFL | Recombinant Full Length Human TRAF3, Flag-tagged | Mamanlian cells | Flag | ||
Human | TRAF3-4611H | Recombinant Human TRAF3 protein | E.coli | N/A | 1-568aa | |
Human | TRAF3-6510H | Recombinant Human TRAF3 Protein (Lys6-Lys351), N-His tagged | E.coli | N-His | Lys6-Lys351 | |
Human | TRAF3-1348H | Recombinant Human TRAF3 Protein, Myc/DDK-tagged, C13 and N15-labeled | HEK293T | Myc/DDK | ||
Human | TRAF3-3617H | Recombinant Human TRAF3 protein, His-tagged | E.coli | His | 1-568aa | |
Human | TRAF3-530HF | Recombinant Full Length Human TRAF3 Protein, GST-tagged | In Vitro Cell Free System | GST | 568 amino acids | |
Mouse | Traf3-6618M | Recombinant Mouse Traf3 Protein, Myc/DDK-tagged | HEK293T | Myc/DDK | ||
Zebrafish | TRAF3-954Z | Recombinant Zebrafish TRAF3 | Mammalian Cell | His |
- Involved Pathway
- Protein Function
- Interacting Protein
- TRAF3 Related Articles
- TRAF3 Related Research Area
TRAF3 involved in several pathways and played different roles in them. We selected most pathways TRAF3 participated on our site, such as NF-kappa B signaling pathway, Toll-like receptor signaling pathway, RIG-I-like receptor signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with TRAF3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
---|---|
NF-kappa B signaling pathway | GM1987;ATM;TNFSF11;DDX58;GM10591;TRAF1;CCL21B;BIRC3;IL1R1 |
Toll-like receptor signaling pathway | IL8L1;CASP8;TRAF3;NFKB1;IL6;CD86;RELA;MAPK12B;TLR5B |
RIG-I-like receptor signaling pathway | OTUD5A;RIPK1L;IFNA13;IFNB;ISG15;NFKBIB;RNF125;CXCL8B.3;CXCL10 |
TNF signaling pathway | TRADD;PIK3CA;MAPK1;MAPK13;MAPK3;MAPK8;BCL3;IL1B;MLKL |
Hepatitis C | OAS1A;RXRA;BAD;CLDN3;MAPK13;AKT1;CLDN10;IFNB1;RELA |
Herpes simplex infection | CSNK2A2A;MAPK9;SRSF7A;CASP3B;TLR9;HLA-DQA2;OAS1;IFNG1-2;PPP1CA |
Epstein-Barr virus infection | MAP2K7;PTMA;SPI1;POLR2J;PIK3CG;POLR3B;SND1;PSMD11;PIK3R5 |
Pathways in cancer | BCL2L1;NKX3;RUNX1T1;LAMA2;WNT9B;NTRK1;RAF1;FGF2;PRKACA |
Viral carcinogenesis | KAT2A;CREB3L3;GTF2E1;NRAS;RB1;HIST1H4C;YWHAG;RBPJL;REL |
Small cell lung cancer | CCND1;LAMA5;BIRC7;PIK3CA;BCL2;ITGA3;COL4A1;LAMB2;LAMA1 |
TRAF3 has several biochemical functions, for example, ligase activity, protein binding, protein kinase binding. Some of the functions are cooperated with other proteins, some of the functions could acted by TRAF3 itself. We selected most functions TRAF3 had, and list some proteins which have the same functions with TRAF3. You can find most of the proteins on our site.
Function | Related Protein |
---|---|
ligase activity | C12orf51;SIAH2L;TRIM2;MKRN3;ITCH;HERC2;RNF152;RNF25;UBE2D1A |
protein binding | PECAM1;SYNJ2;CCNY;HP;KLHL35;REL;MSTN;LDLR;MTAP |
protein kinase binding | SHC4;CD226;EMP2;FAM83B;H2AFY;CCNL1B;CD24;RFFL;SYN1 |
protein phosphatase binding | MAP2K7;STAT6;ANAPC4;TRAF3;STAT3;GNB2L1;CDH5;CDC27;PPP1R3G |
signal transducer activity | GPR183A;TAAR13D;PKP1;AVP;SP110;MAPKAPK2;ITGB3BP;TRHR2;TAAR2 |
thioesterase binding | TRAF6;TRAF3;ADRA2A;TRAF2;CALM1;TRAF4;HAUS7;TRAF1;CDC42 |
tumor necrosis factor receptor binding | TRAF3;LTB;Fasl;TNFSF4;TNFSF10L3;TNFB;TNFSF13B;TRAP1;TNFSF15 |
ubiquitin protein ligase binding | HSPA1A;BLZF1;XRCC5;PER3;UBE2NB;RPA3;ARRB1;FAF2;TNFRSF14 |
ubiquitin-protein transferase activity | IRAK1;TRAF5;HECW2;RBCK1;WWP1;RBBP6;UBE2D1;RNF168;UBE2H |
zinc ion binding | NR5A1;TRIM2;TRIM29;S100A3;PARK2;MAP3K1;VPS41;TIMM13;XIAP |
TRAF3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TRAF3 here. Most of them are supplied by our site. Hope this information will be useful for your research of TRAF3.
TANK; TRAF3IP1; RIPK2; CD40
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