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TRAF3

  • Official Full Name

    TNF receptor-associated factor 3

  • Overview

    The protein encoded by this gene is a member of the TNF receptor associated factor (TRAF) protein family. TRAF proteins associate with, and mediate the signal transduction from, members of the TNF receptor (TNFR) superfamily. This protein participates in the signal transduction of CD40, a TNFR family member important for the activation of the immune response. This protein is found to be a critical component of the lymphotoxin-beta receptor (LTbetaR) signaling complex, which induces NF-kappaB activation and cell death initiated by LTbeta ligation. Epstein-Barr virus encoded latent infection membrane protein-1 (LMP1) can interact with this and several other members of the TRAF family, which may be essential for the oncogenic effects of LMP1. Several alternatively spliced transcript variants encoding three distinct isoforms have been reported.
  • Synonyms

    TRAF3; TNF receptor-associated factor 3; LAP1; CAP-1; CRAF1; CD40bp; CD40 binding protein; CD40 associated protein 1; LMP1-associated protein 1; CD40 receptor associated factor 1; CAP 1; CD40-binding protein; LAP 1; MIPT3; TRAF3_HUMAN;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Human
  • Mouse
  • Zebrafish
  • E.coli
  • HEK293
  • HEK293T
  • In Vitro Cell Free System
  • Mamanlian cells
  • Mammalian Cell
  • Wheat Germ
  • Flag
  • GST
  • His
  • Myc
  • DDK
  • Myc|DDK
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human TRAF3-3385H Recombinant Human TRAF3, GST-tagged Wheat Germ GST
Human TRAF3-3384H Recombinant Human TRAF3, GST-tagged E.coli GST 6-351aa
Human TRAF3-3386H Recombinant Human TRAF3, GST-tagged Wheat Germ GST
Human TRAF3-3387H Recombinant Human TRAF3, MYC/DDK-tagged HEK293 Myc/DDK
Human TRAF3-823HCL Recombinant Human TRAF3 293 Cell Lysate HEK293 N/A
Human TRAF3-822HCL Recombinant Human TRAF3 293 Cell Lysate HEK293 N/A
Human TRAF3-5407HFL Recombinant Full Length Human TRAF3, Flag-tagged Mamanlian cells Flag
Human TRAF3-4611H Recombinant Human TRAF3 protein E.coli N/A 1-568aa
Human TRAF3-6510H Recombinant Human TRAF3 Protein (Lys6-Lys351), N-His tagged E.coli N-His Lys6-Lys351
Human TRAF3-1348H Recombinant Human TRAF3 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human TRAF3-3617H Recombinant Human TRAF3 protein, His-tagged E.coli His 1-568aa
Human TRAF3-530HF Recombinant Full Length Human TRAF3 Protein, GST-tagged In Vitro Cell Free System GST 568 amino acids
Mouse Traf3-6618M Recombinant Mouse Traf3 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Zebrafish TRAF3-954Z Recombinant Zebrafish TRAF3 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • TRAF3 Related Articles
  • TRAF3 Related Research Area

TRAF3 involved in several pathways and played different roles in them. We selected most pathways TRAF3 participated on our site, such as NF-kappa B signaling pathway, Toll-like receptor signaling pathway, RIG-I-like receptor signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with TRAF3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
NF-kappa B signaling pathwayGM1987;ATM;TNFSF11;DDX58;GM10591;TRAF1;CCL21B;BIRC3;IL1R1
Toll-like receptor signaling pathwayIL8L1;CASP8;TRAF3;NFKB1;IL6;CD86;RELA;MAPK12B;TLR5B
RIG-I-like receptor signaling pathwayOTUD5A;RIPK1L;IFNA13;IFNB;ISG15;NFKBIB;RNF125;CXCL8B.3;CXCL10
TNF signaling pathwayTRADD;PIK3CA;MAPK1;MAPK13;MAPK3;MAPK8;BCL3;IL1B;MLKL
Hepatitis COAS1A;RXRA;BAD;CLDN3;MAPK13;AKT1;CLDN10;IFNB1;RELA
Herpes simplex infectionCSNK2A2A;MAPK9;SRSF7A;CASP3B;TLR9;HLA-DQA2;OAS1;IFNG1-2;PPP1CA
Epstein-Barr virus infectionMAP2K7;PTMA;SPI1;POLR2J;PIK3CG;POLR3B;SND1;PSMD11;PIK3R5
Pathways in cancerBCL2L1;NKX3;RUNX1T1;LAMA2;WNT9B;NTRK1;RAF1;FGF2;PRKACA
Viral carcinogenesisKAT2A;CREB3L3;GTF2E1;NRAS;RB1;HIST1H4C;YWHAG;RBPJL;REL
Small cell lung cancerCCND1;LAMA5;BIRC7;PIK3CA;BCL2;ITGA3;COL4A1;LAMB2;LAMA1

TRAF3 has several biochemical functions, for example, ligase activity, protein binding, protein kinase binding. Some of the functions are cooperated with other proteins, some of the functions could acted by TRAF3 itself. We selected most functions TRAF3 had, and list some proteins which have the same functions with TRAF3. You can find most of the proteins on our site.

Function Related Protein
ligase activityC12orf51;SIAH2L;TRIM2;MKRN3;ITCH;HERC2;RNF152;RNF25;UBE2D1A
protein bindingPECAM1;SYNJ2;CCNY;HP;KLHL35;REL;MSTN;LDLR;MTAP
protein kinase bindingSHC4;CD226;EMP2;FAM83B;H2AFY;CCNL1B;CD24;RFFL;SYN1
protein phosphatase bindingMAP2K7;STAT6;ANAPC4;TRAF3;STAT3;GNB2L1;CDH5;CDC27;PPP1R3G
signal transducer activityGPR183A;TAAR13D;PKP1;AVP;SP110;MAPKAPK2;ITGB3BP;TRHR2;TAAR2
thioesterase bindingTRAF6;TRAF3;ADRA2A;TRAF2;CALM1;TRAF4;HAUS7;TRAF1;CDC42
tumor necrosis factor receptor bindingTRAF3;LTB;Fasl;TNFSF4;TNFSF10L3;TNFB;TNFSF13B;TRAP1;TNFSF15
ubiquitin protein ligase bindingHSPA1A;BLZF1;XRCC5;PER3;UBE2NB;RPA3;ARRB1;FAF2;TNFRSF14
ubiquitin-protein transferase activityIRAK1;TRAF5;HECW2;RBCK1;WWP1;RBBP6;UBE2D1;RNF168;UBE2H
zinc ion bindingNR5A1;TRIM2;TRIM29;S100A3;PARK2;MAP3K1;VPS41;TIMM13;XIAP

TRAF3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TRAF3 here. Most of them are supplied by our site. Hope this information will be useful for your research of TRAF3.

TANK; TRAF3IP1; RIPK2; CD40

Chang, JH; Hu, HB; et al. TRAF3 regulates the effector function of regulatory T cells and humoral immune responses. JOURNAL OF EXPERIMENTAL MEDICINE 211:137-151(2014).
Xu, HY; He, XZ; et al. miR-338-5p indirectly regulate BAFF signal by targeting TRAF3 during renal allograft antibody-mediated rejection. JOURNAL OF IMMUNOLOGY 190:-(2013).
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