traf3
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  • Official Full Name
  • TNF receptor-associated factor 3
  • Background
  • The protein encoded by this gene is a member of the TNF receptor associated factor (TRAF) protein family. TRAF proteins associate with, and mediate the signal transduction from, members of the TNF receptor (TNFR) superfamily. This protein participates in the signal transduction of CD40, a TNFR family member important for the activation of the immune response. This protein is found to be a critical component of the lymphotoxin-beta receptor (LTbetaR) signaling complex, which induces NF-kappaB activation and cell death initiated by LTbeta ligation. Epstein-Barr virus encoded latent infection membrane protein-1 (LMP1) can interact with this and several other members of the TRAF family, which may be essential for the oncogenic effects of LMP1. Several alternatively spliced transcript variants encoding three distinct isoforms have been reported.
  • Synonyms
  • TRAF3; TNF receptor-associated factor 3; LAP1; CAP-1; CRAF1; CD40bp; CD40 binding protein; CD40 associated protein 1; LMP1-associated protein 1; CD40 receptor associated factor 1; CAP 1; CD40-binding protein; LAP 1; MIPT3; TRAF3_HUMAN
Cat.#:TRAF3-3384HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human TRAF3, GST-tagged
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Cat.#:TRAF3-3385HTag:GST
Source (Host):Wheat germSpecies:Human
Product nameRecombinant Human TRAF3, GST-tagged
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Cat.#:TRAF3-3386HTag:GST
Source (Host):Wheat germSpecies:Human
Product nameRecombinant Human TRAF3, GST-tagged
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Cat.#:TRAF3-3387HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human TRAF3, MYC/DDK-tagged
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Cat.#:TRAF3-954ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish TRAF3
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Cat.#:TRAF3-822HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human TRAF3 293 Cell Lysate
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Cat.#:TRAF3-823HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human TRAF3 293 Cell Lysate
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Involved Pathway

TRAF3 involved in several pathways and played different roles in them. We selected most pathways TRAF3 participated on our site, such as NF-kappa B signaling pathway, Toll-like receptor signaling pathway, RIG-I-like receptor signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with TRAF3 were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
NF-kappa B signaling pathway
TICAM2; TRIM25; LBP; ERC1; ICAM1; BIRC2; TNFRSF1A; CCL4; TNFRSF13C; RIPK1
Toll-like receptor signaling pathway
MAPK14B; MAP2K7; IFNAR2; IFNA6; IFNB1; IL12BA; PIK3R1; TICAM2; PIK3R3A; IFNA12
RIG-I-like receptor signaling pathway
CXCL10; IKBKB; CASP10; PIN1; TP-1; IKBKE; TNF; IFNA4; IL12B; IFNW1
TNF signaling pathway
MAP2K4; MAPK11; IL1B; TNFRSF1A; IL6; BIRC2; CCL20; PGAM5; PIK3R3; AKT1
Hepatitis C
IFNAR2; SOCS3; TRAF6; IFNA10; MAPK8; IFNA13; TNF; OCLN; MAVS; TRAF2
Herpes simplex infection
EEF1DA; TAB2; SOCS3; CUL1A; IFNA2; BF1; HLA-DQA2; MAPK8; HLA-DRB5; SRSF1
Epstein-Barr virus infection
TRP53; HDAC2; SNW1; PLCG1; PSMD7; TRAF3; HDAC5; HLA-DRB1; TRADD; CCNA2
Pathways in cancer
FGFR3; BAX; MITF; SOS1; STAT1; SPI1; SLC2A1; HSP90AB1; PRKCB; CASP9
Viral carcinogenesis
REL; PRKACB; HIST1H2BA; HIST1H2BH; PIK3R5; YWHAG; GTF2H4; GTF2E1; CDK1; STAT5A
Small cell lung cancer
PIK3CA; PIK3R5; PIK3R3; FN1; CCND1; LAMA3; PIAS2; ITGAV; SKP2; FHIT

Protein Function

TRAF3 has several biochemical functions, for example, ligase activity, protein binding, protein kinase binding. Some of the functions are cooperated with other proteins, some of the functions could acted by TRAF3 itself. We selected most functions TRAF3 had, and list some proteins which have the same functions with TRAF3. You can find most of the proteins on our site.
Function
Related Protein
Function ligase activity
Related Protein TRIM63; RNF34; CTPS1A; TRIM28; TTLL11; TTC3; UHRF2; NHLRC1; MGRN1; NSMCE2
Function protein binding
Related Protein CYTH2; GTF2H4; CFL1; HSD3B7; ITPRIPL1; RAP1GDS1; TSSC4; FOXP4; RAD51D; TFG
Function protein kinase binding
Related Protein CNTLN; PPP1R12B; VRK1; PTPRR; TCF7L2; DBF4B; PKD1; CCND1; CHRNA7; CHEK2
Function protein phosphatase binding
Related Protein ANAPC4; MAP3K5; CSF1R; ANAPC7; MAPK14; PPP1R3G; RPA2; SNX3; CTNNB1; MET
Function signal transducer activity
Related Protein OLFCS1; GRM6B; VMN1R54; GNG4; OPN1MW1; RHOL; LITAF; NDFIP1; VMN1R41; DRD7
Function thioesterase binding
Related Protein TRAF4; TRAF6; CDC42; TRAF5; RAC1; CALM; CALM2; TRAF1; TRAF2; CALM1
Function tumor necrosis factor receptor binding
Related Protein TRAF2; TNFSF13B; EDA; TNFSF12; TNFSF10L; BRE; FADD; TNFSF14; TRIM37; TNFSF10L4
Function ubiquitin protein ligase binding
Related Protein PINK1; KDM4A; BCL10; JAK1; BAG6; HSPA1B; UBE2L3; TMEM189; CUL5; WFS1
Function ubiquitin-protein transferase activity
Related Protein RBCK1; FBXW11; UBE2D4; UBE2E1; UBE3A; TOPORS; MARCH1; TTC3; UBR5; ITCHA
Function zinc ion binding
Related Protein NUP153; RC3H1; CHURC1; VDRA; AMZ2; ADH1C; ZFYVE20; MT1A; PHF7; LHX3

Interacting Protein

TRAF3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TRAF3 here. Most of them are supplied by our site. Hope this information will be useful for your research of TRAF3.
TANK; TRAF3IP1; RIPK2; CD40

TRAF3 Related Articles

Chang, JH; Hu, HB; et al. TRAF3 regulates the effector function of regulatory T cells and humoral immune responses. JOURNAL OF EXPERIMENTAL MEDICINE 211:137-151(2014).
Xu, HY; He, XZ; et al. miR-338-5p indirectly regulate BAFF signal by targeting TRAF3 during renal allograft antibody-mediated rejection. JOURNAL OF IMMUNOLOGY 190:-(2013).