Recombinant Human TRAF3, GST-tagged
Cat.No. : | TRAF3-3384H |
Product Overview : | Recombinant Human TRAF3 protein, fused to GST-tag, was expressed in E.coli and purified by GSH-sepharose. |
Availability | July 01, 2025 |
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Species : | Human |
Source : | E.coli |
Tag : | GST |
Protein Length : | 6-351aa |
Storage : | The protein is stored in PBS buffer at -20℃. Avoid repeated freezing and thawing cycles. |
Storage Buffer : | 1M PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH8. ) added with 100mM GSH and 1% Triton X-100,15%glycerol. |
Gene Name | TRAF3 TNF receptor-associated factor 3 [ Homo sapiens ] |
Official Symbol | TRAF3 |
Synonyms | TRAF3; TNF receptor-associated factor 3; CAP 1; CD40bp; CRAF1; LAP1; CD40 binding protein; CD40 associated protein 1; LMP1-associated protein 1; CD40 receptor associated factor 1; CAP-1; |
Gene ID | 7187 |
mRNA Refseq | NM_001199427 |
Protein Refseq | NP_001186356 |
MIM | 601896 |
UniProt ID | Q13114 |
Chromosome Location | 14q32.32 |
Pathway | Apoptosis, organism-specific biosystem; CD40/CD40L signaling, organism-specific biosystem; Hepatitis C, organism-specific biosystem; Hepatitis C, conserved biosystem; Herpes simplex infection, organism-specific biosystem; Herpes simplex infection, conserv |
Function | ligase activity; metal ion binding; protein binding; signal transducer activity; ubiquitin-protein ligase activity; zinc ion binding; |
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E3 ligase Nedd4l promotes antiviral innate immunity by catalyzing K29-linked cysteine ubiquitination of TRAF3
Journal: Nature Communications PubMed ID: 33608556 Data: 2021/2/19
Authors: Peng Gao, Xianwei Ma, Huazhang An
Article Snippet:LTA (L2515) and Protein G Sepharose (P3296) were from Sigma.LTA (L2515) and Protein G Sepharose (P3296) were from Sigma.. GST-TRAF3 (3384H) was from Creative BioMart.. Recombinant Nedd4l (TP327866) and recombinant TRAF3 (TP318682) were from Origene.Recombinant Nedd4l (TP327866) and recombinant TRAF3 (TP318682) were from Origene.

a Peritoneal macrophages from wild-type ( Nedd4l +/+ ) and Nedd4l-deficient ( Nedd4l ?/? ) mice were infected with VSV (MOI = 10) for indicated time. Phosphorylated and total TBK1, IRF3, p38, JNK, ERK1/2, NF-kB p65, and IκBα were detected by western blot. Intensities of p-TBK1, TBK1, p-IRF3, and IRF3 signals in the three independent experiments were quantified by ImageJ and averages of the signals were shown in graphs. b Wild-type ( Nedd4l +/+ ) and Nedd4l-deficient ( Nedd4l ?/? ) peritoneal macrophages were infected with VSV (MOI = 10) for indicated time, followed by immunoprecipitation (IP) with

a IB of HA-MAVS, HA-TBK1,

a IB of total ubiquitination, K48- and K63-linked ubiquitination of
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