• Official Full Name
  • TRAF3 interacting protein 2
  • Background
  • This gene encodes a protein involved in regulating responses to cytokines by members of the Rel/NF-kappaB transcription factor family. These factors play a central role in innate immunity in response to pathogens, inflammatory signals and stress. This gene product interacts with TRAF proteins (tumor necrosis factor receptor-associated factors) and either I-kappaB kinase or MAP kinase to activate either NF-kappaB or Jun kinase. Several alternative transcripts encoding different isoforms have been identified. Another transcript, which does not encode a protein and is transcribed in the opposite orientation, has been identified. Overexpression of this transcript has been shown to reduce expression of at least one of the protein encoding transcripts, suggesting it has a regulatory role in the expression of this gene.
  • Synonyms
  • TRAF3IP2; TRAF3 interacting protein 2; C6orf2, C6orf4, C6orf5, C6orf6, chromosome 6 open reading frame 2 , chromosome 6 open reading frame 5; adapter protein CIKS; ACT1; CIKS; DKFZP586G0522; NFkB-activating protein ACT1; connection to IKK and SAPK/JNK; nuclear factor NF-kappa-B activator 1; C6orf2; C6orf4; C6orf5; C6orf6; PSORS13; MGC3581
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human TRAF3IP2 Protein, GST-Tagged
Source (Host):Mammalian CellsSpecies:Human
Product nameRecombinant Human TRAF3IP2, His-tagged
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey TRAF3IP2 Protein, His-tagged
Source (Host):Species:Human
Product nameRecombinant Human TRAF3IP2 293 Cell Lysate

Involved Pathway

TRAF3IP2 involved in several pathways and played different roles in them. We selected most pathways TRAF3IP2 participated on our site, such as IL17 signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with TRAF3IP2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
IL17 signaling pathway

Protein Function

TRAF3IP2 has several biochemical functions, for example, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by TRAF3IP2 itself. We selected most functions TRAF3IP2 had, and list some proteins which have the same functions with TRAF3IP2. You can find most of the proteins on our site.
Related Protein
Function protein binding
Related Protein ZFPM2A; TMEM88; NUDT18; PARD6A; AKAP5; HFE; CCDC130; KPNA6; CAND2; RPL13

Interacting Protein

TRAF3IP2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TRAF3IP2 here. Most of them are supplied by our site. Hope this information will be useful for your research of TRAF3IP2.

TRAF3IP2 Related Articles

Ciccacci, C; Perricone, C; et al. A Multilocus Genetic Study in a Cohort of Italian SLE Patients Confirms the Association with STAT4 Gene and Describes a New Association with HCP5 Gene. PLOS ONE 9:-(2014).
Ha, HL; Wang, HS; et al. IL-17 drives psoriatic inflammation via distinct, target cell-specific mechanisms. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 111:E3422-E3431(2014).