trib2
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  • Official Full Name
  • tribbles homolog 2
  • Background
  • This gene encodes one of three members of the Tribbles family. The Tribbles members share a Trb domain, which is homologous to protein serine-threonine kinases, but lacks the active site lysine and probably lacks a catalytic function. The Tribbles proteins interact and modulate the activity of signal transduction pathways in a number of physiological and pathological processes. This Tribbles member induces apoptosis of cells mainly of the hematopoietic origin. It has been identified as a protein up-regulated by inflammatory stimuli in myeloid (THP-1) cells, and also as an oncogene that inactivates the transcription factor C/EBPalpha (CCAAT/enhancer-binding protein alpha) and causes acute myelogenous leukemia. Alternatively spliced transcript variants have been found for this gene.
  • Synonyms
  • TRIB2; tribbles homolog 2 (Drosophila); tribbles homolog 2; GS3955; TRB2; C5FW; FLJ57420
Cat.#:TRIB2-2622HTag:Myc|DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human TRIB2 Protein, MYC/DDK-tagged
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Cat.#:TRIB2-106HTag:His
Source (Host):E.coliSpecies:Human
Product nameRecombinant Human TRIB2 protein, His-tagged
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Cat.#:TRIB2-2217HTag:His|GST
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human TRIB2, His & GST tagged
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Cat.#:TRIB2-24HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human TRIB2, GST-tagged
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Cat.#:TRIB2-3078HTag:N/A
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human TRIB2, None tagged
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Cat.#:TRIB2-3404HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human TRIB2, GST-tagged
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Cat.#:TRIB2-3852HTag:GST
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human Tribbles Homolog 2 (Drosophila), GST-tagged
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Cat.#:TRIB2-17335MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse TRIB2 Protein
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Cat.#:TRIB2-5971CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken TRIB2
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Cat.#:TRIB2-635HCLTag:N/A
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human TRIB2 cell lysate
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Cat.#:TRIB2-645HCLTag:N/A
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human TRIB2 cell lysate
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Protein Function

TRIB2 has several biochemical functions, for example, mitogen-activated protein kinase kinase binding, NOT nucleotide binding, NOT protein kinase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by TRIB2 itself. We selected most functions TRIB2 had, and list some proteins which have the same functions with TRIB2. You can find most of the proteins on our site.
Function
Related Protein
Function mitogen-activated protein kinase kinase binding
Related Protein ARRB1; DLG1; IGBP1; RAF1; BRAF; TAOK2; MAP3K11; ACE; TRIB3; TRIB2
Function NOT nucleotide binding
Related Protein PXK; TRIB2
Function NOT protein kinase activity
Related Protein TRIB2; HSPB8; MLKL; STRADB; STRADA; PXK; TRIB1
Function protein kinase inhibitor activity
Related Protein SOCS6B; DNAJC3; TESC; SH3BP5L; TRIB3; SOCS1; CHP1; CISHB; GMFG; SOCS3A
Function transcription factor binding
Related Protein MED12; DAXX; NAB2; MYBBP1A; MED25; KCTD1; HES1; APBB3; CHCHD2; NCOR2
Function ubiquitin protein ligase binding
Related Protein TMEM173; TRAF2; MC1R; MYOD1; RANGAP1; PRKAR1A; PPARGC1A; NKD2; UBE2G1A; TRIB2
Function ubiquitin-protein transferase regulator activity
Related Protein TRIB2; TRIB3; TRIB1

Interacting Protein

TRIB2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TRIB2 here. Most of them are supplied by our site. Hope this information will be useful for your research of TRIB2.
LRRK2; BTRC; PRMT6; SLAMF7; UBQLN4; CARD16; TCF4; CTNNB1; RFWD2; SMURF1

TRIB2 Related Articles

Lind, A; Ramelius, A; et al. A/H1N1 antibodies and TRIB2 autoantibodies in narcolepsy patients diagnosed in conjunction with the Pandemrix vaccination campaign in Sweden 2009-2010. JOURNAL OF AUTOIMMUNITY 50:99-106(2014).
Katzav, A; Arango, MT; et al. Passive transfer of narcolepsy: Anti-TRIB2 autoantibody positive patient IgG causes hypothalamic orexin neuron loss and sleep attacks in mice. JOURNAL OF AUTOIMMUNITY 45:24-30(2013).