Recombinant Full Length Human TRIB2 Protein, C-Flag-tagged

• Cat.No.: TRIB2-1626HFL
• Product Overview: Recombinant Full Length Human TRIB2 Protein, fused to Flag-tag at C-terminus, was expressed in Mammalian cells.

Specification

• Description: This gene encodes one of three members of the Tribbles family. The Tribbles members share a Trb domain, which is homologous to protein serine-threonine kinases, but lacks the active site lysine and probably lacks a catalytic function. The Tribbles proteins interact and modulate the activity of signal transduction pathways in a number of physiological and pathological processes. This Tribbles member induces apoptosis of cells mainly of the hematopoietic origin. It has been identified as a protein up-regulated by inflammatory stimuli in myeloid (THP-1) cells, and also as an oncogene that inactivates the transcription factor C/EBPalpha (CCAAT/enhancer-binding protein alpha) and causes acute myelogenous leukemia. Alternatively spliced transcript variants have been found for this gene.
• Source: Mammalian cells
• Species: Human
• Tag: Flag
• Form: 25 mM Tris HCl, pH 7.3, 100 mM glycine, 10% glycerol.
• Molecular Mass: 38.6 kDa
• AA Sequence: MNIHRSTPITIARYGRSRNKTQDFE ELSSIRSAEPSQSFSPNLGSPSPPE TPNLSHCVSCIGKYLLLEPL EGDHVFRAVHLHSGEELVCKVFDIS CYQESLAPCFCLSAHSNINQITEII LGETKAYVFFERSYGDMHSF VRTCKKLREEEAARLFYQIASAVAH CHDGGLVLRDLKLRKFIFKDEERTR VKLESLEDAYILRGDDDSLS DKHGCPAYVSPEILNTSGSYSGKAA DVWSLGVMLYTMLVGRYPFHDIEPS SLFSKIRRGQFNIPETLSPK
  AKCLIRSILRREPSERLTSQEILDH PWFSTDFSVSNSAYGAKEVSDQLVP DVNMEENLDPFFNTRTRPLEQKLIS EEDLAANDILDYKDDDDKV
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining.
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade.
• Concentration: >50 ug/mL as determined by microplate BCA method.
• Preparation: Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps.
• Protein Families: Druggable Genome, Protein Kinase

Gene Information

• Gene Name: TRIB2 tribbles pseudokinase 2 [ Homo sapiens (human) ]
• Official Symbol: TRIB2
• Synonyms: C5FW; TRB2; GS3955
• Gene ID: 28951
• mRNA Refseq: NM_021643.4
• Protein Refseq: NP_067675.1
• MIM: 609462
• UniProt ID: Q92519