Recombinant Human TRIB2 Protein, His-tagged

• Cat.No.: TRIB2-326H
• Product Overview: Recombinant protein from the full-length sequence of Homo sapiens tribbles pseudokinase 2 (TRIB2), transcript variant 1 (NM_021643), with a His tag was expressed in human cells.

Specification

• Description: This gene encodes one of three members of the Tribbles family. The Tribbles members share a Trb domain, which is homologous to protein serine-threonine kinases, but lacks the active site lysine and probably lacks a catalytic function. The Tribbles proteins interact and modulate the activity of signal transduction pathways in a number of physiological and pathological processes. This Tribbles member induces apoptosis of cells mainly of the hematopoietic origin. It has been identified as a protein up-regulated by inflammatory stimuli in myeloid (THP-1) cells, and also as an oncogene that inactivates the transcription factor C/EBPalpha (CCAAT/enhancer-binding protein alpha) and causes acute myelogenous leukemia. Alternatively spliced transcript variants have been found for this gene.
• Source: Human Cells
• Species: Human
• Tag: His
• Molecular Mass: 38.6 kDa
• Endotoxin: Endotoxin level is < 0.1 ng/µg of protein (<1EU /µg)
• Purity: >90% by SDS-PAGE gel and Coomassie Blue staining
• Applications: Antigens, Western, ELISA and other in vitro binding or in vivo functional assays, and protein-protein interaction studies; For research & development use only!
• Storage Buffer: Purified protein formulated in a sterile solution of PBS buffer, pH7.2, without any preservatives

Gene Information

• Gene Name: TRIB2 tribbles pseudokinase 2 [ Homo sapiens (human) ]
• Official Symbol: TRIB2
• Synonyms: TRIB2; tribbles pseudokinase 2; C5FW; TRB2; GS3955; tribbles homolog 2
• Gene ID: 28951
• mRNA Refseq: NM_021643
• Protein Refseq: NP_067675
• MIM: 609462
• UniProt ID: Q92519