trim63
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  • Official Full Name
  • tripartite motif containing 63, E3 ubiquitin protein ligase
  • Background
  • This gene encodes a member of the RING zinc finger protein family found in striated muscle and iris. The product of this gene is an E3 ubiquitin ligase that localizes to the Z-line and M-line lattices of myofibrils. This protein plays an important role in the atrophy of skeletal and cardiac muscle and is required for the degradation of myosin heavy chain proteins, myosin light chain, myosin binding protein, and for muscle-type creatine kinase. [provided by RefSeq, Feb 2012]
  • Synonyms
  • TRIM63; tripartite motif containing 63, E3 ubiquitin protein ligase; IRF; SMRZ; MURF1; MURF2; RNF28; E3 ubiquitin-protein ligase TRIM63; ring finger protein 28; iris ring finger protein; muscle specific ring finger protein 2; muscle-specific RING finger protein 1; tripartite motif-containing protein 63; striated muscle RING zinc finger protein;
Cat.#:TRIM63-111HTag:His|SUMO
Source (Host):E.coliSpecies:Human
Product nameRecombinant Human TRIM63, His & SUMO-tagged
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Cat.#:TRIM63-139HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human TRIM63
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Cat.#:TRIM63-30260THTag:N/A
Source (Host):Wheat germSpecies:Human
Product nameRecombinant Human TRIM63
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Cat.#:TRIM63-6283RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat TRIM63 Protein
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Cat.#:TRIM63-4973RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey TRIM63 Protein, His-tagged
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Cat.#:TRIM63-360ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish TRIM63
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Cat.#:Trim63-2164RTag:GST
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Tripartite Motif-containing 63, GST-tagged
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Cat.#:TRIM63-1833HCLTag:N/A
Source (Host):Species:Human
Product nameRecombinant Human TRIM63 cell lysate
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Involved Pathway

Trim63 involved in several pathways and played different roles in them. We selected most pathways Trim63 participated on our site, such as Adaptive Immune System, Antigen processing: Ubiquitination &, Proteasome degradation, which may be useful for your reference. Also, other proteins which involved in the same pathway with Trim63 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Adaptive Immune System
PIK3AP1; CMTM2A; ITK; KLRG1; SIGLEC5; TRIM39; EGFR; EGF; TREM1; ASB18
Antigen processing: Ubiquitination &
TRIM11; RNF6; TRIM50; KLHL20; UBE2F; ASB8; UBE2U; ASB18; ASB4; UFL1
Proteasome degradation
IWS1; TRAF7; RNF182; VPRBP; FBXO44; FBXO27; ASB3; UBE2J2; HECTD3; ASB18
Class I MHC mediated antigen processing &
ASB3; CTSS; GAN; PJA1; RNF144B; UBE2J2; UBR1; RNF111; TRIM69; HUWE1
presentation
CTSL1; UBE2E3; FBXO17; PJA1; UBE2F; CYBA; GAN; ASB18; LRRC41; RNF4
Immune System
SIGLEC9; RNF19B; HCST; SPSB2; KLHL21; EDAR; SIGLEC8; POLR3F; CD300LF; PJA1
TWEAK Signaling Pathway
TRIM63; TNFSF12-TNFSF13

Protein Function

Trim63 has several biochemical functions, for example, ligase activity, protein binding, signal transducer activity. Some of the functions are cooperated with other proteins, some of the functions could acted by Trim63 itself. We selected most functions Trim63 had, and list some proteins which have the same functions with Trim63. You can find most of the proteins on our site.
Function
Related Protein
Function ligase activity
Related Protein RNF168; TRIM5; CBX4; NSMCE1; RNF20; HECTD2; CDC34B; TRIM32; RNF181; SHPRH
Function protein binding
Related Protein TNPO3; EAF2; C11orf68; NVL; PDIA2; CTDNEP1; PKIA; UCN; KATNA1; SPANXC
Function signal transducer activity
Related Protein OLFCH1; PARAPINOPSINB; GRM6A; GPR52; EMR4; RERG; V2RX1; LPAR6A; OLFR149; TAAR7F
Function titin binding
Related Protein CAPN3; CALM3; TRIM63; ANKRD1B; ACTN2; CALM; ANKRD23; CAMK2D; OBSCN; CALM1
Function ubiquitin protein ligase activity
Related Protein RNF121; CBL; MED10; RNF144AB; RNF165; RAG2; LRSAM1; UBE2KB; COP1; RLIM
Function zinc ion binding
Related Protein RNF187; MARCH11; MYT1LA; RARAA; Car12; ZSWIM1; ATXN7L3; NR6A1B; ZCCHC16; CXXC1

Interacting Protein

Trim63 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Trim63 here. Most of them are supplied by our site. Hope this information will be useful for your research of Trim63.
TTN; EEF1G; CCAR1; MRPL41; GFM1; MYOZ1; NDUFA1; TCAP; NEBL; SNAPIN; ATP5B; TNNT1