ttn
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  • Official Full Name
  • titin
  • Background
  • This gene encodes a large abundant protein of striated muscle. The product of this gene is divided into two regions, a;N-terminal I-band and a C-terminal A-band. The I-band, which is the elastic part of the molecule, contains two regions;of tandem immunoglobulin domains on either side of a PEVK region that is rich in proline, glutamate, valine and;lysine. The A-band, which is thought to act as a protein-ruler, contains a mixture of immunoglobulin and fibronectin;repeats, and possesses kinase activity. An N-terminal Z-disc region and a C-terminal M-line region bind to the Z-line;and M-line of the sarcomere, respectively, so that a single titin molecule spans half the length of a sarcomere. Titin;also contains binding sites for muscle associated proteins so it serves as an adhesion template for the assembly of;contractile machinery in muscle cells. It has also been identified as a structural protein for chromosomes.;Alternative splicing of this gene results in multiple transcript variants. Considerable variability exists in the;I-band, the M-line and the Z-disc regions of titin. Variability in the I-band region contributes to the differences in;elasticity of different titin isoforms and, therefore, to the differences in elasticity of different muscle types.;Mutations in this gene are associated with familial hypertrophic cardiomyopathy 9, and autoantibodies to titin are;produced in patients with the autoimmune disease scleroderma.
  • Synonyms
  • TTN; titin; cardiomyopathy, dilated 1G (autosomal dominant) , CMD1G; CMH9; CMPD4; FLJ32040; LGMD2J; MYLK5; TMD; connectin; rhabdomyosarcoma antigen MU-RMS-40.14; CMD1G; EOMFC; HMERF; FLJ26020; FLJ26409; FLJ34413; FLJ39564; FLJ43066; DKFZp451N061
Cat.#:TTN-1391HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human TTN Protein, His-tagged
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Cat.#:TTN-1780HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human TTN protein, His-tagged
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Cat.#:TTN-25HTag:GST/His
Source (Host):Wheat germSpecies:Human
Product nameRecombinant Human TTN, GST-tagged
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Cat.#:TTN-26HTag:GST
Source (Host):Wheat germSpecies:Human
Product nameRecombinant Human TTN, GST-tagged
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Cat.#:TTN-27HTag:GST
Source (Host):Wheat germSpecies:Human
Product nameRecombinant Human TTN, GST-tagged
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Cat.#:TTN-705HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Titin
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Involved Pathway

TTN involved in several pathways and played different roles in them. We selected most pathways TTN participated on our site, such as Hypertrophic cardiomyopathy (HCM), Dilated cardiomyopathy, which may be useful for your reference. Also, other proteins which involved in the same pathway with TTN were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Hypertrophic cardiomyopathy (HCM)
ITGB8; CACNB4; IL6; ACE; ITGA10; Itga10&Itgb1; MYH7; SGCB; TPM1; ITGB7
Dilated cardiomyopathy
TNF; ITGB8; CACNG8; ITGA10; ITGA6; TGFB2; ITGA4; TTN; ACTB; TPM1

Protein Function

TTN has several biochemical functions, for example, ATP binding, actin filament binding, actinin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by TTN itself. We selected most functions TTN had, and list some proteins which have the same functions with TTN. You can find most of the proteins on our site.
Function
Related Protein
Function ATP binding
Related Protein TTLL3; CASKB; ABL2; HSP104; MAT2AA; DALRD3; MAST4; VPRBP; PMVK; IGF1RA
Function actin filament binding
Related Protein ANXA8; SYNE3; ANTXR1; SPTA1; CTNNA2; CORO1C; FLNA; LIMA1; TULP1; MYH11
Function actinin binding
Related Protein CSRP3; PDLIM5; TTN; RELA; NFKB1; PKD2; MICALL2; PROM1
Function calcium ion binding
Related Protein CDH19; FAT1A; ANXA2; SLC24A1; CAPN11; MMP20; CA; EMR4; FBLN2; DSG1C
Function calmodulin binding
Related Protein RRAD; CNN3; ADCY3; SCN5A; ADD1; ADD3; MARCKS; SLC9A1; MIP; MKNK2
Function enzyme binding
Related Protein SLC18A1; Ar; UGT1A3; IL6R; PTPN1; SIRT1; CSF3; NOTCH3; ANK1; SUPT5H
Function identical protein binding
Related Protein SLC22A1; ROBO2; UGP2; EIF2AK3; PCBD1; PYDC3; MPZL2B; KHDC1B; CRYBB2; CRYAB
Function muscle alpha-actinin binding
Related Protein PDLIM2; MYPN; NRAP; PALLD; PKD2L1; TTN; PKD2; LDB3
Function protease binding
Related Protein TP53; MALT1; INS1; KIT; Cstb; ITGB1; PYCARD; PANX1; ANXA2; NDUFS7
Function protein binding
Related Protein PSIP1; RPS6KA5; HDHD2; DNASE1; SP1; AIPL1; FBXW9; HSPB7; CDKN2C; TLR13
Function protein kinase binding
Related Protein TRAF3; FAF1; ERRFI1; GATA4; FOXO3; CHEK2; PRDX3; TRIB3; PTPN23; DAXX
Function protein self-association
Related Protein ZKSCAN17; AXIN1; TP53; NKX3-1; DYRK1A; CNTN2; AGA; SYP; PCSK9; SLC9A3R1
Function protein serine/threonine kinase activity
Related Protein PRKY; MAP4K2; STRC; SMOK2B; PRKCHA; PLK2B; PRKCA; ADCK1; STK17A; DYRK1B
Function protein tyrosine kinase activity
Related Protein KIT; ALK; TESK1; FGFR2; TTN; TYK2; EPHA4A; KITB; RET; DYRK4
Function structural constituent of muscle
Related Protein ACTN3; SORBS2; MYL6; MYBPH; DAG1; TCAP; TPM2; MYL1; ACTN2; TTN
Function structural molecule activity conferring elasticity
Related Protein TTN; AHNAK
Function telethonin binding
Related Protein MYOZ2; TTN; KCNE1; CSRP3; BMP10

TTN Related Articles

Matsumoto, Y; Zhang, Q; et al. Trimeric Tn Antigen on Syndecan 1 Produced by ppGalNAc-T13 Enhances Cancer Metastasis via a Complex Formation with Integrin alpha 5 beta 1 and Matrix Metalloproteinase 9. JOURNAL OF BIOLOGICAL CHEMISTRY 288:24264-24276(2013).
Cutino-Avila, B; Cunill-Semanat, E; et al. Synthesis of Tetanus Toxoid-Sepharose CL 4B derivatives by Rational Design. 5TH LATIN AMERICAN CONGRESS ON BIOMEDICAL ENGINEERING (CLAIB 2011): SUSTAINABLE TECHNOLOGIES FOR THE HEALTH OF ALL, PTS 1 AND 2 33:160-163(2013).