ttn
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  • Official Full Name
  • titin
  • Background
  • This gene encodes a large abundant protein of striated muscle. The product of this gene is divided into two regions, a;N-terminal I-band and a C-terminal A-band. The I-band, which is the elastic part of the molecule, contains two regions;of tandem immunoglobulin domains on either side of a PEVK region that is rich in proline, glutamate, valine and;lysine. The A-band, which is thought to act as a protein-ruler, contains a mixture of immunoglobulin and fibronectin;repeats, and possesses kinase activity. An N-terminal Z-disc region and a C-terminal M-line region bind to the Z-line;and M-line of the sarcomere, respectively, so that a single titin molecule spans half the length of a sarcomere. Titin;also contains binding sites for muscle associated proteins so it serves as an adhesion template for the assembly of;contractile machinery in muscle cells. It has also been identified as a structural protein for chromosomes.;Alternative splicing of this gene results in multiple transcript variants. Considerable variability exists in the;I-band, the M-line and the Z-disc regions of titin. Variability in the I-band region contributes to the differences in;elasticity of different titin isoforms and, therefore, to the differences in elasticity of different muscle types.;Mutations in this gene are associated with familial hypertrophic cardiomyopathy 9, and autoantibodies to titin are;produced in patients with the autoimmune disease scleroderma.
  • Synonyms
  • TTN; titin; cardiomyopathy, dilated 1G (autosomal dominant) , CMD1G; CMH9; CMPD4; FLJ32040; LGMD2J; MYLK5; TMD; connectin; rhabdomyosarcoma antigen MU-RMS-40.14; CMD1G; EOMFC; HMERF; FLJ26020; FLJ26409; FLJ34413; FLJ39564; FLJ43066; DKFZp451N061
Cat.#:TTN-1391HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human TTN Protein, His-tagged
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Cat.#:TTN-1780HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human TTN protein, His-tagged
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Cat.#:TTN-25HTag:GST/His
Source (Host):Wheat germSpecies:Human
Product nameRecombinant Human TTN, GST-tagged
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Cat.#:TTN-26HTag:GST
Source (Host):Wheat germSpecies:Human
Product nameRecombinant Human TTN, GST-tagged
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Cat.#:TTN-27HTag:GST
Source (Host):Wheat germSpecies:Human
Product nameRecombinant Human TTN, GST-tagged
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Cat.#:TTN-705HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Titin
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Involved Pathway

TTN involved in several pathways and played different roles in them. We selected most pathways TTN participated on our site, such as Hypertrophic cardiomyopathy (HCM), Dilated cardiomyopathy, which may be useful for your reference. Also, other proteins which involved in the same pathway with TTN were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Hypertrophic cardiomyopathy (HCM)
SGCD; TTN; IGF1; PRKAB2; CACNG1; CACNA2D1; TGFB2; IL6; SLC8A1; PRKAA2
Dilated cardiomyopathy
PRKACB; DES; ITGA2; ITGA7; GNAS; CACNG7; SGCD; CACNG3; ITGB3; ITGA9

Protein Function

TTN has several biochemical functions, for example, ATP binding, actin filament binding, actinin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by TTN itself. We selected most functions TTN had, and list some proteins which have the same functions with TTN. You can find most of the proteins on our site.
Function
Related Protein
Function ATP binding
Related Protein STK19; HK2; MAP3K14; HSPA13; ACTR2A; NLRP9C; NAGK; KIF4; UBE1Y1; HSP90B1
Function actin filament binding
Related Protein DBNL; TRIOBPB; MYH11A; PICK1; TMOD1; TTN; CORO6; NEXN; ARPC1A; ADSSL1
Function actinin binding
Related Protein PDLIM5; CSRP3; PKD2; TTN; RELA; NFKB1; MICALL2; PROM1
Function calcium ion binding
Related Protein DNASE1L2; LALBA; C2CD4B; MICU2; PCDH1G11; PCDH2G29; ITSN2B; PPP3CB; SLIT1; ADAMTS13
Function calmodulin binding
Related Protein MYO1A; MARCKSL1B; MAPKAPK2; CAMK2D; PDE1A; RGS16; PDE1B; MYH7; GRIN1; CAMSAP1
Function enzyme binding
Related Protein MAPT; ZNHIT6; PRKCE; TUT1; MARCH6; SCN5A; NOXA1; TAF10; SORT1; UGT1A6
Function identical protein binding
Related Protein PAFAH1B3; ESR1; L3MBTL1; PCM1; GOT2A; SP100; C10orf88; VWA1; NOXO1; PFKM
Function muscle alpha-actinin binding
Related Protein PALLD; PKD2; PKD2L1; NRAP; TTN; PDLIM2; LDB3; MYPN
Function protease binding
Related Protein TIMP2B; POLG; TIMP1; MBP; TTN; TIMP3; FURIN; ADAM8A; LDLR; THAP5
Function protein binding
Related Protein AFG3L2; WNK1; KLF5; SMIM3; OPRM1; TESC; FGD2; SLAMF6; HHLA3; KLHL35
Function protein kinase binding
Related Protein HCLS1; GATA4; CCNY; ADIPOR1; AP1B1; KCNQ3; VRK1; TMEM173; MS4A2; PLK1S1
Function protein self-association
Related Protein SLC2A1; ZNF496; ZFP639; BCL10; ADAM8; TMEM190; CTSB; TRP53; PCSK9; SYP
Function protein serine/threonine kinase activity
Related Protein NEK6; VRK1; BCR; ZAK; RAF1A; AKT3A; ZNF143B; CAMK2D1; STK25; CDC7
Function protein tyrosine kinase activity
Related Protein WEE2; TYRO3; SRC; IGF1RB; MAP3K9; TESK2; EK1; MAP2K5; PTK7; EPHA7
Function structural constituent of muscle
Related Protein PLEC; MYL2; MYBPC3; MYH11; MYBPC1; ASPH; MYLPF; MYL6B; CSRP3; MYOM1
Function structural molecule activity conferring elasticity
Related Protein TTN; AHNAK
Function telethonin binding
Related Protein BMP10; TTN; KCNE1; CSRP3; MYOZ2

TTN Related Articles

Matsumoto, Y; Zhang, Q; et al. Trimeric Tn Antigen on Syndecan 1 Produced by ppGalNAc-T13 Enhances Cancer Metastasis via a Complex Formation with Integrin alpha 5 beta 1 and Matrix Metalloproteinase 9. JOURNAL OF BIOLOGICAL CHEMISTRY 288:24264-24276(2013).
Cutino-Avila, B; Cunill-Semanat, E; et al. Synthesis of Tetanus Toxoid-Sepharose CL 4B derivatives by Rational Design. 5TH LATIN AMERICAN CONGRESS ON BIOMEDICAL ENGINEERING (CLAIB 2011): SUSTAINABLE TECHNOLOGIES FOR THE HEALTH OF ALL, PTS 1 AND 2 33:160-163(2013).