tyrp1
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  • Official Full Name
  • tyrosinase-related protein 1
  • Background
  • This gene encodes a melanosomal enzyme that belongs to the tyrosinase family and plays an important role in the melanin biosynthetic pathway. Defects in this gene are the cause of rufous oculocutaneous albinism and oculocutaneous albinism type III.
  • Synonyms
  • TYRP1; tyrosinase-related protein 1; CAS2, TYRP; 5,6-dihydroxyindole-2-carboxylic acid oxidase; b PROTEIN; CATB; GP75; TRP; 56 dihydroxyindole 2 carboxylic acid oxidase precursor; CAS2; Catalase B; DHICA oxidase; Glycoprotein 75; Melanoma antigen gp75; TRP1; Tyrosinase related protein 1; TYRP; TYRRP; TRP-1; OTTHUMP00000022788; b-PROTEIN
Cat.#:TYRP1-2963HTag:Myc|DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human TYRP1 Protein, MYC/DDK-tagged
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Cat.#:TYRP1-22HTag:His
Source (Host):Insect cellsSpecies:Human
Product nameRecombinant Human TYRP1 protein, His-tagged
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Cat.#:TYRP1-511HTag:His
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human TYRP1 Protein, His-tagged
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Cat.#:TYRP1-512HTag:His
Source (Host):HEK293Species:Human
Product nameRecombinant Human TYRP1 Protein, His-tagged
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Cat.#:Tyrp1-1007MTag:His
Source (Host):Baculovirus-Insect CellsSpecies:Mouse
Product nameRecombinant Mouse Tyrp1 Protein, His-tagged
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Cat.#:TYRP1-17676MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse TYRP1 Protein
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Cat.#:TYRP1-6602CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken TYRP1
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Cat.#:TYRP1-1641HCLTag:N/A
Source (Host):HEK293Species:Human
Product nameRecombinant Human TYRP1 cell lysate
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Cat.#:TYRP1-473HCLTag:N/A
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human TYRP1 cell lysate
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Involved Pathway

TYRP1 involved in several pathways and played different roles in them. We selected most pathways TYRP1 participated on our site, such as Tyrosine metabolism, Metabolic pathways, Melanogenesis, which may be useful for your reference. Also, other proteins which involved in the same pathway with TYRP1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Tyrosine metabolism
AOX2P; TYR; ADH2-2; AOC2; GOT2; IL4I1; ADH1; TPO; AOX3; TH
Metabolic pathways
MTMR6; UAP1; FDFT1; NMRK1; CYP8B1; GLUD2; UGT1A4; GGT6; AKR1B7; ALDH1B1
Melanogenesis
CALML3; FZD10; GNAO1B; KITB; FZD3; CALM1A; FZD3A; Fzd4; CAMK2D2; WNT9A

Protein Function

TYRP1 has several biochemical functions, for example, copper ion binding, oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, another compound as one donor, and incorporation of one atom of oxygen, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by TYRP1 itself. We selected most functions TYRP1 had, and list some proteins which have the same functions with TYRP1. You can find most of the proteins on our site.
Function
Related Protein
Function copper ion binding
Related Protein POLR1B; COMMD1; ADNP; PRNP; SNCA; TRP53; S100V2; LOXL3B; PARK7; S100A5
Function oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, another compound as one donor, and incorporation of one atom of oxygen
Related Protein TYRP1B; TYRP1
Function protein binding
Related Protein PTPN14; CEP350; XRCC5; BEGAIN; C12orf68; TIMM8A; KAT2B; PDE6H; LPHN1; BLZF1
Function protein heterodimerization activity
Related Protein TAS1R2; ABTB2; TAF9; MAFA; HIST1H4L; HIST4H4; TRP53; PPARD; IKBKB; SRI
Function protein homodimerization activity
Related Protein NPM1; CECR1; IKZF2; NFKB1; VPS25; FLNA; NFS1; CRYBB2; CCL5; PFKM

Interacting Protein

TYRP1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TYRP1 here. Most of them are supplied by our site. Hope this information will be useful for your research of TYRP1.
GIPC1

TYRP1 Related Articles

Davidov, T; Nagar, M; et al. Carbonic anhydrase 4 and crystallin alpha-B immunoreactivity may distinguish benign from malignant thyroid nodules in patients with indeterminate thyroid cytology. JOURNAL OF SURGICAL RESEARCH 190:565-574(2014).
Ghanem, G; Fabrice, J; et al. Tyrosinase related protein 1 (TYRP1/gp75) in human cutaneous melanoma. MOLECULAR ONCOLOGY 5:150-155(2011).