Trim63

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Trim63

Official Full Name tripartite motif containing 63, E3 ubiquitin protein ligase
Background This gene encodes a member of the RING zinc finger protein family found in striated muscle and iris. The product of this gene is an E3 ubiquitin ligase that localizes to the Z-line and M-line lattices of myofibrils. This protein plays an important role in the atrophy of skeletal and cardiac muscle and is required for the degradation of myosin heavy chain proteins, myosin light chain, myosin binding protein, and for muscle-type creatine kinase. [provided by RefSeq, Feb 2012]
Synonyms TRIM63; tripartite motif containing 63, E3 ubiquitin protein ligase; IRF; SMRZ; MURF1; MURF2; RNF28; E3 ubiquitin-protein ligase TRIM63; ring finger protein 28; iris ring finger protein; muscle specific ring finger protein 2; muscle-specific RING finger protein 1; tripartite motif-containing protein 63; striated muscle RING zinc finger protein;
    • Species :
    • Human
    • Rat
    • Rhesus Macaque
    • Zebrafish
    • Source :
    • E.coli
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • SUMO
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human TRIM63-111H Recombinant Human TRIM63, His & SUMO-tagged E.coli His/SUMO
    Human TRIM63-139H Recombinant Human TRIM63 E.coli N/A
    Human TRIM63-1833HCL Recombinant Human TRIM63 cell lysate N/A
    Human TRIM63-30260TH Recombinant Human TRIM63 Wheat Germ N/A
    Rat Trim63-2164R Recombinant Rat Tripartite Motif-containing 63, GST-tagged E.coli GST
    Rat TRIM63-6283R Recombinant Rat TRIM63 Protein Mammalian Cell His
    Rhesus Macaque TRIM63-4973R Recombinant Rhesus monkey TRIM63 Protein, His-tagged Mammalian Cell His
    Zebrafish TRIM63-360Z Recombinant Zebrafish TRIM63 Mammalian Cell His

    Trim63 involved in several pathways and played different roles in them. We selected most pathways Trim63 participated on our site, such as Adaptive Immune System, Antigen processing: Ubiquitination &amp, Proteasome degradation, which may be useful for your reference. Also, other proteins which involved in the same pathway with Trim63 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Adaptive Immune System CTLA4; AP1S1; LRRC41; CTSO; PDPK1A; UBE2F; RNF182; ASB9; ASB11; UBE2L6
    Antigen processing: Ubiquitination &amp SPSB2; RBCK1; ASB17; TRIM9; RNF123; ASB13; DZIP3; ASB2; ASB9; RNF25
    Proteasome degradation ASB11; ASB9; RBCK1; LRR1; ASB14; UCHL3; UBR2; KLHL20; SPSB4; ASB8
    Class I MHC mediated antigen processing &amp RNF220; FBXO3; CTSL2; ERAP2; RNF138; TRIM50; RNF6; TRIM63; SH3RF1; UBE2U
    presentation UBE2V1; ASB8; ASB11; PJA2; WWP1; LRR1; RNF4; STUB1; RNF19B; TRIM69
    Immune System BTLA; RNF6; UBE2J2; TRIM56; PPAPDC1A; FBXO17; ART1; BST2; WWP1; LRSAM1
    TWEAK Signaling Pathway TNFSF12-TNFSF13; TRIM63

    Trim63 has several biochemical functions, for example, ligase activity, protein binding, signal transducer activity. Some of the functions are cooperated with other proteins, some of the functions could acted by Trim63 itself. We selected most functions Trim63 had, and list some proteins which have the same functions with Trim63. You can find most of the proteins on our site.

    Function Related Protein
    ligase activity TRIM8; HERC6; MYLIPB; DTX3L; TRIM6; UBE4B; MIB1; HECW1B; RNF126; UBR4
    protein binding IL-8; LRCH4; RASD1; FARSA; RIBC2; NFS1; MNDA; ZNF346; SMYD2; KAZN
    signal transducer activity OLFR497; GULP1; TAS2R103; ITGB3BP; CBL; FKBP1A; OLFR149; TAAR14D; PKP1; TAAR12B
    titin binding CALM1; TRIM63; TCAP; MYBPC1; ANKRD1B; CALM; OBSCN; ACTN2; MYBPC3; SLC14A2
    ubiquitin protein ligase activity UBR3; RNF24; RNF144B; RNF146; UBR5; PDZRN4; ZNRF1; SIAH1A; RNF6; FBXO30
    zinc ion binding UBOX5; GATAD2B; BIRC2; TRIM8A; PIAS4; EWSR1A; ZDHHC16B; LTN1; ZMAT2; RNF144AB

    Trim63 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Trim63 here. Most of them are supplied by our site. Hope this information will be useful for your research of Trim63.

    TTN; EEF1G; CCAR1; MRPL41; GFM1; MYOZ1; NDUFA1; TCAP; NEBL; SNAPIN; ATP5B; TNNT1

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