UBA6
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Official Full Name
ubiquitin-like modifier activating enzyme 6
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Overview
Modification of proteins with ubiquitin (UBB; MIM 191339) or ubiquitin-like proteins controls many signaling networks;and requires a ubiquitin-activating enzyme (E1), a ubiquitin conjugating enzyme (E2), and a ubiquitin protein ligase;(E3). UBE1L2 is an E1 enzyme that initiates the activation and conjugation of ubiquitin-like proteins (Jin et al.,;2007 (PubMed 17597759)). -
Synonyms
UBA6; ubiquitin-like modifier activating enzyme 6; UBE1L2, ubiquitin activating enzyme E1 like 2; ubiquitin-like modifier-activating enzyme 6; FLJ10808; ubiquitin activating enzyme E1; E1-L2; FLJ23367; Monocyte protein 4; MOP 4; MOP-4; MOP4; UBA 6; UBA6 ubiquitin activating enzyme E1; UBA6_HUMAN; UBE1L2; Ubiquitin activating enzyme 6; Ubiquitin activating enzyme E1 like 2; Ubiquitin activating enzyme E1 like protein 2; Ubiquitin like modifier activating enzyme 6; Ubiquitin-activating enzyme 6; Ubiquitin-activating enzyme E1-like protein 2; OTTHUMP00000159634; UBA6, ubiquitin-activating enzyme E1; ubiquitin-activating enzyme E1-like 2;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Human
- Mouse
- E.coli
- HEK293
- HEK293T
- In Vitro Cell Free System
- Insect Cell
- Mammalian Cell
- Sf9 Insect Cell
- Wheat Germ
- Flag
- FLAG
- GST
- His
- His (Fc)
- Avi
- Strep
- Myc
- DDK
- N/A
- N
- No tag
- Involved Pathway
- Protein Function
- Interacting Protein
- UBA6 Related Research Area
UBA6 involved in several pathways and played different roles in them. We selected most pathways UBA6 participated on our site, such as Ubiquitin mediated proteolysis, which may be useful for your reference. Also, other proteins which involved in the same pathway with UBA6 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Ubiquitin mediated proteolysis | SIAH1;CBL;CUL1;SYVN1;UBE2KB;UBE2F;WWP2;MGRN1A;UBOX5 |
UBA6 has several biochemical functions, for example, ATP binding, FAT10 activating enzyme activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by UBA6 itself. We selected most functions UBA6 had, and list some proteins which have the same functions with UBA6. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ATP binding | SRPK3;BTK;HK3;DHX35;KCNJ11;CAMK2D;EPHB2;BRAF;IGHMBP2 |
| FAT10 activating enzyme activity | |
| protein binding | CST7;ZCCHC7;ADAP2;GLI1;C4BPA;ATF3;MC3R;YWHAE;TMEM139 |
| ubiquitin activating enzyme activity | SAE1;ATG7;UBA1;UBA6;UBA7;UBE1Y1 |
UBA6 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with UBA6 here. Most of them are supplied by our site. Hope this information will be useful for your research of UBA6.
HMBOX1; SMAD9; EIF4A3; FXR1; FMR1
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