uba6
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  • Official Full Name
  • ubiquitin-like modifier activating enzyme 6
  • Background
  • Modification of proteins with ubiquitin (UBB; MIM 191339) or ubiquitin-like proteins controls many signaling networks;and requires a ubiquitin-activating enzyme (E1), a ubiquitin conjugating enzyme (E2), and a ubiquitin protein ligase;(E3). UBE1L2 is an E1 enzyme that initiates the activation and conjugation of ubiquitin-like proteins (Jin et al.,;2007 (PubMed 17597759)).
  • Synonyms
  • UBA6; ubiquitin-like modifier activating enzyme 6; UBE1L2, ubiquitin activating enzyme E1 like 2; ubiquitin-like modifier-activating enzyme 6; FLJ10808; ubiquitin activating enzyme E1; E1-L2; FLJ23367; Monocyte protein 4; MOP 4; MOP-4; MOP4; UBA 6; UBA6 ubiquitin activating enzyme E1; UBA6_HUMAN; UBE1L2; Ubiquitin activating enzyme 6; Ubiquitin activating enzyme E1 like 2; Ubiquitin activating enzyme E1 like protein 2; Ubiquitin like modifier activating enzyme 6; Ubiquitin-activating enzyme 6; Ubiquitin-activating enzyme E1-like protein 2; OTTHUMP00000159634; UBA6, ubiquitin-activating enzyme E1; ubiquitin-activating enzyme E1-like 2
Cat.#:UBA6-4225HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human UBA6 Protein, GST-tagged
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Cat.#:UBA6-106HTag:FLAG
Source (Host):Insect CellsSpecies:Human
Product nameRecombinant Human UBA6, FLAG-tagged
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Cat.#:UBA6-149HTag:GST
Source (Host):Sf 9 insect cellsSpecies:Human
Product nameRecombinant Human UBA6, GST-tagged
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Cat.#:UBA6-2440HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human UBA6, GST-tagged
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Cat.#:UBA6-31449THTag:Flag
Source (Host):Species:Human
Product nameRecombinant Human UBA6, FLAG-tagged
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Cat.#:UBA6-3518HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human UBA6, GST-tagged
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Cat.#:UBA6-46HTag:Flag
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Rat Vascular Endothelial Growth Factor A
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Cat.#:UBA6-17692MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse UBA6 Protein
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Cat.#:UBA6-602HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human UBA6 293 Cell Lysate
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Involved Pathway

UBA6 involved in several pathways and played different roles in them. We selected most pathways UBA6 participated on our site, such as Ubiquitin mediated proteolysis, which may be useful for your reference. Also, other proteins which involved in the same pathway with UBA6 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Ubiquitin mediated proteolysis
ANAPC5; FBXW11A; CBLB; BIRC3; NEDD4L; PML; CUL3B; DET1; TRIM32; UBA2

Protein Function

UBA6 has several biochemical functions, for example, ATP binding, FAT10 activating enzyme activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by UBA6 itself. We selected most functions UBA6 had, and list some proteins which have the same functions with UBA6. You can find most of the proteins on our site.
Function
Related Protein
Function ATP binding
Related Protein YES1; GSK3B; FKBP4; EIF2AK1; MAPK12; KIF2C; KIF7; IP6K3; MADD; BLK
Function FAT10 activating enzyme activity
Related Protein UBA6
Function protein binding
Related Protein HEXIM1; DHRS2; PEF1; ALOX5; COMMD9; RAB38; BAZ2A; FGFR1B; MAPK14; CDK17
Function ubiquitin activating enzyme activity
Related Protein SAE1; UBE1Y1; UBA1; UBA6; ATG7; UBA7

Interacting Protein

UBA6 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with UBA6 here. Most of them are supplied by our site. Hope this information will be useful for your research of UBA6.
HMBOX1; SMAD9; EIF4A3; FXR1; FMR1