UBE2A Protein, ubiquitin-conjugating enzyme E2A

UBE2A

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UBE2A

Official Full Name ubiquitin-conjugating enzyme E2A
Background The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, ubiquitin-conjugating enzymes, and ubiquitin-protein ligases. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is required for post-replicative DNA damage repair, and may play a role in transcriptional regulation. Mutations in this gene are associated with mental retardation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]
Synonyms UBE2A; ubiquitin-conjugating enzyme E2A; UBC2; HHR6A; MRXSN; RAD6A; MRXS30; ubiquitin-conjugating enzyme E2 A; RAD6 homolog A; ubiquitin-protein ligase A; ubiquitin carrier protein A;
    • Species :
    • Chicken
    • Human
    • Rhesus Macaque
    • Zebrafish
    • Source :
    • E.coli
    • HEK293
    • Mammalian Cell
    • Tag :
    • His
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human UBE2A-219H Recombinant Human UBE2A, His-tagged E.coli His
    Human UBE2A-530H Recombinant Human UBE2A Protein, His-tagged E.coli His
    Human UBE2A-53H Recombinant Human UBE2A, His-tagged E.coli His
    Human UBE2A-594HCL Recombinant Human UBE2A 293 Cell Lysate HEK293 N/A
    Human UBE2A-595HCL Recombinant Human UBE2A 293 Cell Lysate HEK293 N/A
    Human UBE2A-642H Recombinant Human UBE2A Protein, His-tagged, Active E.coli His
    Human UBE2A-849H Recombinant Human UBE2A, His tagged E.coli His
    Rhesus Macaque UBE2A-5053R Recombinant Rhesus monkey UBE2A Protein, His-tagged Mammalian Cell His
    Chicken UBE2A-6428C Recombinant Chicken UBE2A Mammalian Cell His
    Zebrafish UBE2A-11433Z Recombinant Zebrafish UBE2A Mammalian Cell His

    UBE2A involved in several pathways and played different roles in them. We selected most pathways UBE2A participated on our site, such as Ubiquitin mediated proteolysis, which may be useful for your reference. Also, other proteins which involved in the same pathway with UBE2A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Ubiquitin mediated proteolysis SMURF1; HERC3; PARK2; UBE2L3A; TCEB1; UBE2B; HERC4; UBE4B; CDC26; CUL5

    UBE2A has several biochemical functions, for example, ATP binding, protein binding, ubiquitin conjugating enzyme activity. Some of the functions are cooperated with other proteins, some of the functions could acted by UBE2A itself. We selected most functions UBE2A had, and list some proteins which have the same functions with UBE2A. You can find most of the proteins on our site.

    Function Related Protein
    ATP binding MAP4K1; RHOBTB3; OAS1; TXK; ADCY8; CSK; SUCLG2; NUBP2; AK4; PEX1
    protein binding GMPPA; RBMX2; ANLN; KCTD15; CDK4; CTNNAL1; GFAP; C16orf48; EFHA1; KTI12
    ubiquitin conjugating enzyme activity UBE2D1; UBE2Z; UBE2A; UBE2E3; UBE2Q2; CDC34; UBE2N; UBE2QL1; UBE2J2; UBE2G1
    ubiquitin protein ligase activity RAG2; WWP1; CDC34A; HLTF; CDC34B; NHLRC1; HERC5; SMURF1; RNF149; SIAH2
    ubiquitin protein ligase binding MDM2; TUBB; POLR2A; TCEB2; UBE2Z; UBE2J2; EGR2; VCL; TOLLIP; MOAP1
    ubiquitin-protein transferase activity SIAH1A; RNF141; HECTD3; UBR1; RNF168; TSPAN17; TRIP12; ANKIB1A; RNF5; RNF41

    UBE2A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with UBE2A here. Most of them are supplied by our site. Hope this information will be useful for your research of UBE2A.

    SDCBP; RAD18; RNF20; HAT1; TRIM27; BSG; CRMP1; UBR4; UBR3; UBR1; CMTM2; ETNK2

    Bermejo-Alvarez, P; Rizos, D; et al. Transcriptional sexual dimorphism in elongating bovine embryos: implications for XCI and sex determination genes. REPRODUCTION 141:801-808(2011).
    Zhang, H; Zhao, WJ; et al. Characterization of a Moniezia expansa ubiquitin-conjugating enzyme E2 cDNA. MOLECULAR BIOLOGY REPORTS 37:1585-1590(2010).

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