ube2a
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  • Official Full Name
  • ubiquitin-conjugating enzyme E2A
  • Background
  • The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, ubiquitin-conjugating enzymes, and ubiquitin-protein ligases. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is required for post-replicative DNA damage repair, and may play a role in transcriptional regulation. Mutations in this gene are associated with mental retardation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]
  • Synonyms
  • UBE2A; ubiquitin-conjugating enzyme E2A; UBC2; HHR6A; MRXSN; RAD6A; MRXS30; ubiquitin-conjugating enzyme E2 A; RAD6 homolog A; ubiquitin-protein ligase A; ubiquitin carrier protein A;
Cat.#:UBE2A-219HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human UBE2A, His-tagged
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Cat.#:UBE2A-530HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human UBE2A Protein, His-tagged
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Cat.#:UBE2A-642HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human UBE2A Protein, His-tagged, Active
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Cat.#:UBE2A-849HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human UBE2A, His tagged
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Cat.#:UBE2A-5053RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey UBE2A Protein, His-tagged
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Cat.#:UBE2A-6428CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken UBE2A
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Cat.#:UBE2A-11433ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish UBE2A
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Cat.#:UBE2A-53HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human UBE2A, His-tagged
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Cat.#:UBE2A-594HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human UBE2A 293 Cell Lysate
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Cat.#:UBE2A-595HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human UBE2A 293 Cell Lysate
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Involved Pathway

UBE2A involved in several pathways and played different roles in them. We selected most pathways UBE2A participated on our site, such as Ubiquitin mediated proteolysis, which may be useful for your reference. Also, other proteins which involved in the same pathway with UBE2A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Ubiquitin mediated proteolysis
UBE2H; RNF7; CDC16; CDC34; SOCS3; UBE2NB; UBE2E1; UBA7; UBE2D2L; UBE2R2

Protein Function

UBE2A has several biochemical functions, for example, ATP binding, protein binding, ubiquitin conjugating enzyme activity. Some of the functions are cooperated with other proteins, some of the functions could acted by UBE2A itself. We selected most functions UBE2A had, and list some proteins which have the same functions with UBE2A. You can find most of the proteins on our site.
Function
Related Protein
Function ATP binding
Related Protein MST1R; UBE2G2; VARS; SKIV2L; AK1; PYGL; TTLL6; ATPBD4; TPK1; UBE2I
Function protein binding
Related Protein PTPRE; PLCG2; RIMS2; HSPB6; ARRB1; SHPRH; PRIMPOL; MAGEB18; NOL6; UBR2
Function ubiquitin conjugating enzyme activity
Related Protein UBE2V2; UBE2N; UBE2H; UBE2D2A; UBE2Z; UBE2L3; UBE2G2; UBE2A; UBE2QL1; UBE2D4
Function ubiquitin protein ligase activity
Related Protein RNF19B; RNF152; HECW2; NEURL3; RNF175; TRIM3; RNF25; ZNRF1; RFFL; CDC34B
Function ubiquitin protein ligase binding
Related Protein UBOX5; HSPD1; DAXX; PPARGC1A; OTUB1; MAGEC2; RNF40; GABARAP; PTPN22; TNFRSF1B
Function ubiquitin-protein transferase activity
Related Protein RNF168; UBE2Q2; TRIM56; SIAH2L; BTR22; RNF4; BRCA1; UBE2L3; TRIP12; BIRC5B

Interacting Protein

UBE2A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with UBE2A here. Most of them are supplied by our site. Hope this information will be useful for your research of UBE2A.
SDCBP; RAD18; RNF20; HAT1; TRIM27; BSG; CRMP1; UBR4; UBR3; UBR1; CMTM2; ETNK2

UBE2A Related Articles

Bermejo-Alvarez, P; Rizos, D; et al. Transcriptional sexual dimorphism in elongating bovine embryos: implications for XCI and sex determination genes. REPRODUCTION 141:801-808(2011).
Zhang, H; Zhao, WJ; et al. Characterization of a Moniezia expansa ubiquitin-conjugating enzyme E2 cDNA. MOLECULAR BIOLOGY REPORTS 37:1585-1590(2010).