ube2b
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  • Official Full Name
  • ubiquitin-conjugating enzyme E2B
  • Background
  • The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is required for post-replicative DNA damage repair. Its protein sequence is 100% identical to the mouse, rat, and rabbit homologs, which indicates that this enzyme is highly conserved in eukaryotic evolution.
  • Synonyms
  • UBE2B; ubiquitin-conjugating enzyme E2B; ubiquitin conjugating enzyme E2B (RAD6 homolog); ubiquitin-conjugating enzyme E2 B; HHR6B; RAD6B; UBC2; E2 protein; RAD6 homolog B; ubiquitin-protein ligase B; ubiquitin carrier protein B; ubiquitin-conjugating enz
Cat.#:UBE2B-31450THTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human UBE2B, His-tagged
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Cat.#:UBE2B-3526HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human UBE2B, GST-tagged
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Cat.#:UBE2B-531HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human UBE2B Protein, His-tagged
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Cat.#:UBE2B-615HTag:His
Source (Host):HEK293 cellsSpecies:Human
Product nameRecombinant Human UBE2B Protein, His-tagged
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Cat.#:UBE2B-616HTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human UBE2B Protein
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Cat.#:UBE2B-1006MTag:
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse UBE2B Protein
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Cat.#:UBE2B-6393RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat UBE2B Protein
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Cat.#:UBE2B-1071CTag:His
Source (Host):Mammalian CellsSpecies:Cynomolgus Monkey
Product nameRecombinant Cynomolgus UBE2B Protein, His-tagged
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Cat.#:UBE2B-5054RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey UBE2B Protein, His-tagged
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Cat.#:UBE2B-843ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish UBE2B
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Cat.#:UBE2B-07HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Ubiquitin Conjugating Enzyme E2B
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Cat.#:UBE2B-55HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human UBE2B, His-tagged
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Cat.#:UBE2B-593HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human UBE2B 293 Cell Lysate
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Involved Pathway

UBE2B involved in several pathways and played different roles in them. We selected most pathways UBE2B participated on our site, such as Ubiquitin mediated proteolysis, which may be useful for your reference. Also, other proteins which involved in the same pathway with UBE2B were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Ubiquitin mediated proteolysis
BIRC2; BIRC8; RCHY1; HERC4; PRP19; FBXW8; CDC34A; FBXO4; UBE2G1B; UBE2D1B

Protein Function

UBE2B has several biochemical functions, for example, ATP binding, protein binding, ubiquitin conjugating enzyme activity. Some of the functions are cooperated with other proteins, some of the functions could acted by UBE2B itself. We selected most functions UBE2B had, and list some proteins which have the same functions with UBE2B. You can find most of the proteins on our site.
Function
Related Protein
Function ATP binding
Related Protein FYN; STK19; PKM; MAP3K13; THRAP3; RIPK1L; TYK2; TAOK2; ROCK1; PGK1
Function protein binding
Related Protein HMGB2; APOBEC3G; NAP1L2; MARCKSL1; SRA1; MTA1; COL23A1; RNF146; GNA14; HIST1H3D
Function ubiquitin conjugating enzyme activity
Related Protein UBE2V1; UBE2E3; UBE2A; UBE2E1; UBE2J1; UBE2G1; UBE2D2; UBE2Z; UBE2O; UBE2V2
Function ubiquitin protein ligase activity
Related Protein RNF121; HERC6; RNF220; SIAH2L; RNF7; UBE3C; RFWD2; HECW1B; MED20; AMFR
Function ubiquitin protein ligase binding
Related Protein AMBRA1; PER3; TANK; CUL3; WASH1; YWHAZ; UBXN1; GSK3B; YWHAE; XBP1
Function ubiquitin-protein transferase activity
Related Protein ARIH1; BIRC5A; UBE2W; ZNRF1; UBE2B; BRCA1; UBR5; RNF220; UBE2G2; NEDD4L

Interacting Protein

UBE2B has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with UBE2B here. Most of them are supplied by our site. Hope this information will be useful for your research of UBE2B.
RNF20; RAD18; UBC; UNC119; CRMP1; UBR4; UBR3; UBR1; IRF7; MED31; RNF40; PEX2; CDC73