ube2c
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  • Official Full Name
  • ubiquitin-conjugating enzyme E2C
  • Background
  • UbcH10 in conjunction with the anaphase-promoting complex catalyzes the destruction of cyclins A and B and therefore plays an important role in the control of the cell exit from mitosis.
  • Synonyms
  • UBE2C; ubiquitin-conjugating enzyme E2C; ubiquitin-conjugating enzyme E2 C; UBCH10; ubiquitin-protein ligase C; ubiquitin carrier protein C; ubiquitin carrier protein E2-C; cyclin-selective ubiquitin carrier protein; mitotic-specific ubiquitin-conjugating enzyme; dJ447F3.2
Cat.#:UBE2C-118HTag:
Source (Host):E.coliSpecies:Human
Product nameRecombinant Human UBE2C
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Cat.#:UBE2C-221HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human UBE2C, His-tagged
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Cat.#:UBE2C-3527HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human UBE2C, GST-tagged
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Cat.#:UBE2C-643HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human UBE2C Protein, His-tagged, Active
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Cat.#:UBE2C-899HTag:Met/His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human UBE2C Protein, Met & His-tagged
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Cat.#:UBE2C-900HTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human UBE2C
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Cat.#:UBE2C-1072CTag:His
Source (Host):Mammalian CellsSpecies:Cynomolgus Monkey
Product nameRecombinant Cynomolgus UBE2C Protein, His-tagged
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Cat.#:UBE2C-3585ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish UBE2C
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Cat.#:UBE2C-10HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Ubiquitin Conjugating Enzyme 10,His-tagged
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Cat.#:UBE2C-04HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Ubiquitin Conjugating Enzyme 10, His6-Tagged
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Cat.#:UBE2C-591HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human UBE2C 293 Cell Lysate
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Cat.#:UBE2C-592HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human UBE2C 293 Cell Lysate
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Involved Pathway

UBE2C involved in several pathways and played different roles in them. We selected most pathways UBE2C participated on our site, such as APC-Cdc20 mediated degradation of Nek2A, APC/C-mediated degradation of cell cycle proteins, APC/C:Cdc20 mediated degradation of Cyclin B, which may be useful for your reference. Also, other proteins which involved in the same pathway with UBE2C were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
APC-Cdc20 mediated degradation of Nek2A
NEK2; UBE2C; ANAPC10
APC/C-mediated degradation of cell cycle proteins
PSME3; PSMD9; PSMA8; CDK2; PSMD14; AURKB; PSMD5; NEK2; ANAPC10; UBE2C
APC/C:Cdc20 mediated degradation of Cyclin B
UBE2C; ANAPC10
APC/C:Cdc20 mediated degradation of Securin
PSME3; PSMA8; PSMD5; UBE2C; PSMD9; ANAPC10; PSMD14; PSMD10
APC/C:Cdc20 mediated degradation of mitotic proteins
PSMA8; UBE2C; PSMD9; ANAPC10; PSMD5; PSMD14; PSMD10; PSME3; NEK2
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
UBE2C; PSME3; ANAPC10; PSMD10; PSMD9; PSMD5; PSMA8; PSMD14; AURKB
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint
PSME3; PSMD10; NEK2; PSMD9; UBE2C; ANAPC10; PSMA8; PSMD14; PSMD5
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins
PSME3; PSMD10; UBE2C; PSMD5; NEK2; ANAPC10; PSMD14; PSMD9; PSMA8

Protein Function

UBE2C has several biochemical functions, for example, ATP binding, protein binding, ubiquitin conjugating enzyme activity. Some of the functions are cooperated with other proteins, some of the functions could acted by UBE2C itself. We selected most functions UBE2C had, and list some proteins which have the same functions with UBE2C. You can find most of the proteins on our site.
Function
Related Protein
Function ATP binding
Related Protein TTLL6; STK17A; BUB1B; CLPXA; RAD51C; EPHB3A; ADCY9; SGK2B; CAMKVB; ABCB1
Function protein binding
Related Protein NKRF; KCTD14; SMARCAD1; YIPF3; SNAP23; UBE2Q1; PPEF1; CTSC; SKAP2; GRIA2
Function ubiquitin conjugating enzyme activity
Related Protein UBE2N; UBE2B; UBE2D4; UBE2J1; UBE2E3; UBE2L3; UBE2E2; UBE2D2; UBE2QL1; UBE2G2
Function ubiquitin protein ligase activity
Related Protein RNF2; FLJ11011L; UBE2Z; ITCHA; RNF139; UBE2G1B; MED10; UBE2B; RAG1; CDC42
Function ubiquitin protein ligase binding
Related Protein DERL1; CDKN1A; SMAD6; HSPA9; BRCA1; TRAF1; CUL1; CALR; ACVR1B; BCL2
Function ubiquitin-protein transferase activity
Related Protein UBE2T; MALT1; UBR1; RNF182; UBE2B; TRAF7; UBE2D4; RNF144B; TRIM23; CDC23
Function contributes_to ubiquitin-protein transferase activity
Related Protein KLHL12; KLHL24; KBTBD5; KLHL22; KLHL40A; BACH2; TCEB1; KLHL30; KLHDC7A; RNF20

Interacting Protein

UBE2C has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with UBE2C here. Most of them are supplied by our site. Hope this information will be useful for your research of UBE2C.
UBE2V1; ENO2; CXCR1; TNNC1; PCGF3; DTX1; RANBP9; EBNA1BP2; P