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UBQLN2

Official Full Name

ubiquilin 2
Overview

This gene encodes an ubiquitin-like protein (ubiquilin) that shares high degree of similarity with related products in yeast, rat and frog. Ubiquilins contain a N-terminal ubiquitin-like domain and a C-terminal ubiquitin-associated domain. They physically associate with both proteasomes and ubiquitin ligases; and thus, are thought to functionally link the ubiquitination machinery to the proteasome to affect in vivo protein degradation. This ubiquilin has also been shown to bind the ATPase domain of the Hsp70-like Stch protein.
Synonyms

UBQLN2; ubiquilin 2; ubiquilin-2; Chap1; CHAP1/DSK2; Dsk2; LIC 2; N4BP4; NEDD4 binding protein 4; PLIC 2; PLIC2; RIHFB2157; ubiquitin-like product Chap1/Dsk2; protein linking IAP with cytoskeleton 2; ALS15; HRIHFB2157;

Type

Recombinant Proteins
Protein Pre-coupled Magnetic Beads

Species

Human
Mouse

Source

E.coli
HEK293
In Vitro Cell Free System
Mammalian Cell
Wheat Germ

Tag

GST
His
His (Fc)
Avi
N

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	UBQLN2-3559H	Recombinant Human UBQLN2, GST-tagged	E.coli	GST	1-624aa	$319 / 25ug
Human	UBQLN2-46H	Recombinant Human UBQLN2 protein, His-tagged	E.coli	His		Inquiry
Human	UBQLN2-96H	Recombinant Human UBQLN2, GST-tagged	Wheat Germ	GST		Inquiry
Human	UBQLN2-5838H	Recombinant Human UBQLN2 Protein (Ile33-Ala126), N-GST tagged	E.coli	N-GST	Ile33-Ala126	Inquiry
Human	UBQLN2-613H	Recombinant Human UBQLN2 Protein, His-tagged	E.coli	His	Ile33~Ala126	$298 / 10ug
Human	UBQLN2-545HF	Recombinant Full Length Human UBQLN2 Protein, GST-tagged	In Vitro Cell Free System	GST	624 amino acids	Inquiry
Mouse	UBQLN2-17756M	Recombinant Mouse UBQLN2 Protein	Mammalian Cell	His		Inquiry
Mouse	UBQLN2-9856M-B	Recombinant Mouse UBQLN2 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Mouse	UBQLN2-9856M	Recombinant Mouse UBQLN2 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry

Involved Pathway
Protein Function
Interacting Protein
UBQLN2 Related Articles

UBQLN2 involved in several pathways and played different roles in them. We selected most pathways UBQLN2 participated on our site, such as Protein processing in endoplasmic reticulum, which may be useful for your reference. Also, other proteins which involved in the same pathway with UBQLN2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Protein processing in endoplasmic reticulum	UBQLN1;HYOU1;LMAN1L;RRBP1;DNAJC5GA;RRBP1A;UBQLNL;TUSC3;CUL1B

UBQLN2 has several biochemical functions, for example, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by UBQLN2 itself. We selected most functions UBQLN2 had, and list some proteins which have the same functions with UBQLN2. You can find most of the proteins on our site.

Function	Related Protein
protein binding	GLYCTK;TCEB3;KRT20;CSNK1G1;CDCA5;ECM1;MID1IP1;SOX30;CDK7

UBQLN2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with UBQLN2 here. Most of them are supplied by our site. Hope this information will be useful for your research of UBQLN2.

ADRM1; RAD23A; RPN13; RPN10; RPN10; PSMD4; ATXN7; PRPF40A; C1QA; CD93

Ajroud-Driss, S; Siddique, T; et al. Sporadic and hereditary amyotrophic lateral sclerosis (ALS). BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE 1852:679-684(2015).

Osaka, M; Ito, D; et al. Evidence of a link between ubiquilin 2 and optineurin in amyotrophic lateral sclerosis. HUMAN MOLECULAR GENETICS 24:1617-1629(2015).