ugt1a6
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  • Official Full Name
  • UDP glucuronosyltransferase 1 family, polypeptide A6
  • Background
  • This gene encodes a UDP-glucuronosyltransferase, an enzyme of the glucuronidation pathway that transforms small lipophilic molecules, such as steroids, bilirubin, hormones, and drugs, into water-soluble, excretable metabolites. This gene is part of a complex locus that encodes several UDP-glucuronosyltransferases. The locus includes thirteen unique alternate first exons followed by four common exons. Four of the alternate first exons are considered pseudogenes. Each of the remaining nine 5 exons may be spliced to the four common exons, resulting in nine proteins with different N-termini and identical C-termini. Each first exon encodes the substrate binding site, and is regulated by its own promoter. The enzyme encoded by this gene is active on phenolic and planar compounds. Alternative splicing in the unique 5 end of this gene results in two transcript variants.
  • Synonyms
  • UGT1A6; UDP glucuronosyltransferase 1 family, polypeptide A6; UDP glycosyltransferase 1 family, polypeptide A6; UDP-glucuronosyltransferase 1-6; GNT1; HLUGP; UGT1F; HLUGP1; Phenol metabolizing UDP glucuronosyltransferase; Phenol-metabolizing UDP-glucuronosyltransferase; UD16_HUMAN; UDP glucuronosyltransferase 1 family polypeptide A6; UDP glucuronosyltransferase 1A6; UDP glycosyltransferase 1 family polypeptide A6; UDP-glucuronosyltransferase 1-F; UDP-glucuronosyltransferase 1A6; UDPGT; UDPGT 1-6; UGT 1F; UGT-1F; UGT1; UGT1 06; UGT1*6; UGT1-06; UGT1.6; UDP-glucuronosyltransferase 1 family polypeptide A6s; UGT1A6S
Cat.#:UGT1A6-12HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human UGT1A6 protein, MYC/DDK-tagged
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Cat.#:UGT1A6-208HTag:GST
Source (Host):Wheat germSpecies:Human
Product nameRecombinant Human UGT1A6, GST-tagged
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Cat.#:UGT1A6-31663THTag:
Source (Host):Species:Human
Product nameRecombinant Human UGT1A6
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Cat.#:UGT1A6-6432RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat UGT1A6 Protein
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Cat.#:UGT1A6-7719ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish UGT1A6
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Cat.#:UGT1A6-511HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human UGT1A6 293 Cell Lysate
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Involved Pathway

UGT1A6 involved in several pathways and played different roles in them. We selected most pathways UGT1A6 participated on our site, such as Pentose and glucuronate interconversions, Ascorbate and aldarate metabolism, Steroid hormone biosynthesis, which may be useful for your reference. Also, other proteins which involved in the same pathway with UGT1A6 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Pentose and glucuronate interconversions
UGT2A1; UGT1AB; ALDH3A2A; ALDH1B1; RPE; UGP2B; DCXR; UGT1A7C; OXSR1; UGT2A3
Ascorbate and aldarate metabolism
ALDH1B1; ALDH9A1B; UGT1A6; UGT1A1; UGT1A2; UGT1A7; UGDH; MIOX; ALDH9A1; ALDH2
Steroid hormone biosynthesis
CYP2C54; HSD3B4; HSD17B12A; AKR1D1; CYP2B19; SRD5A2; CYP2C55; UGT1A7C; UGT1A1; CYP2D10
Starch and sucrose metabolism
UGDH; HK3; UGT1A6B; UGT5G1; PGM2L1; UGT1A7; AMY2A4; UGT1A9; G6PC; UGT2B15
Retinol metabolism
Aldh1a7; RETSATL; UGT1AB; CYP3A7-CYP3AP1; ADH2-1; UGT1A3; CYP2C39; DGAT1A; RPE65; CYP2A4
Porphyrin and chlorophyll metabolism
EPRS; UGT1AB; UGT2A2; UGT1A6B; CP; MMAB; UGT1A4; EARS2; UGT5G1; PPOX
Metabolism of xenobiotics by cytochrome P
GSTA2; UGT1A9; GSTM4; GSTA3; UGT1A7; UGT1A7C; GSTM5; CYP1A; UGT5G1; CBR3
Drug metabolism - cytochrome P
GSTA; UGT1A6; ALDH3A1; MGST3; AOX2P; GSTM; GSTM6; MGST2; AOX4; UGT1A7C
Drug metabolism - other enzymes
NAT1; UGT2A2; UGT1A7; UGT1A2; UMPS; Ces2c; UGT2B7; TK2; Nat3; UPP1
Metabolic pathways
ACSM2B; MUT; CYP7A1A; ATP6V1C1; ST3GAL4; PLA2G6; BDH2; ASAH1B; ACADSB; TM7SF2
Chemical carcinogenesis
CYP3A41B; ADH7; PTGS2; ADH6; ADH1; MGST3; ADH4; SULT1A4; ARNT; MGST1

Protein Function

UGT1A6 has several biochemical functions, for example, enzyme binding, glucuronosyltransferase activity, NOT glucuronosyltransferase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by UGT1A6 itself. We selected most functions UGT1A6 had, and list some proteins which have the same functions with UGT1A6. You can find most of the proteins on our site.
Function
Related Protein
Function enzyme binding
Related Protein TBP; HMGA1; PLSCR1; PRKCD; APOA1; ERN1; AXIN1; DNMT3L; NOXA1; JUN
Function glucuronosyltransferase activity
Related Protein UGT3A2; B3GAT3; CSGALNACT1; UGT2B7; UGT1A9; UGT2B1; UGT1A3; UGT2A3; UGT5F1; UGT1A4
Function NOT glucuronosyltransferase activity
Related Protein UGT1A7; UGT1A1; UGT1A6; UGT1A4; UGT1A3; UGT1A9
Function protein heterodimerization activity
Related Protein TAF13; MCL1A; SEPHS1; PVALB; TAP1; CHRNB2; HIST1H2B8; FZD1; H2AFZ; KCNK9
Function protein homodimerization activity
Related Protein OLFM4; S100B; SIAH1A; TRPM8; PTPRO; GRIK1; KCNN2; DGCR8; DMRTB1; SMAD2
Function NOT retinoic acid binding
Related Protein UGT2B7; UGT2B15; UGT1A4; UGT1A6

UGT1A6 Related Articles

Uchihashi, S; Nishikawa, M; et al. The critical role of amino acid residue at position 117 of mouse UDP-glucuronosyltransfererase 1a6a and 1a6b in resveratrol glucuronidation. JOURNAL OF BIOCHEMISTRY 152:331-340(2012).
Milne, AM; Burchell, B; et al. A Novel Method for the Immunoquantification of UDP-Glucuronosyltransferases in Human Tissue. DRUG METABOLISM AND DISPOSITION 39:2258-2263(2011).