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UGT1A6

Official Full Name

UDP glucuronosyltransferase 1 family, polypeptide A6
Overview

This gene encodes a UDP-glucuronosyltransferase, an enzyme of the glucuronidation pathway that transforms small lipophilic molecules, such as steroids, bilirubin, hormones, and drugs, into water-soluble, excretable metabolites. This gene is part of a complex locus that encodes several UDP-glucuronosyltransferases. The locus includes thirteen unique alternate first exons followed by four common exons. Four of the alternate first exons are considered pseudogenes. Each of the remaining nine 5 exons may be spliced to the four common exons, resulting in nine proteins with different N-termini and identical C-termini. Each first exon encodes the substrate binding site, and is regulated by its own promoter. The enzyme encoded by this gene is active on phenolic and planar compounds. Alternative splicing in the unique 5 end of this gene results in two transcript variants.
Synonyms

UGT1A6; UDP glucuronosyltransferase 1 family, polypeptide A6; UDP glycosyltransferase 1 family, polypeptide A6; UDP-glucuronosyltransferase 1-6; GNT1; HLUGP; UGT1F; HLUGP1; Phenol metabolizing UDP glucuronosyltransferase; Phenol-metabolizing UDP-glucuronosyltransferase; UD16_HUMAN; UDP glucuronosyltransferase 1 family polypeptide A6; UDP glucuronosyltransferase 1A6; UDP glycosyltransferase 1 family polypeptide A6; UDP-glucuronosyltransferase 1-F; UDP-glucuronosyltransferase 1A6; UDPGT; UDPGT 1-6; UGT 1F; UGT-1F; UGT1; UGT1 06; UGT1*6; UGT1-06; UGT1.6; UDP-glucuronosyltransferase 1 family polypeptide A6s; UGT1A6S;

Type

Recombinant Proteins
Cell & Tissue Lysates
Protein Pre-coupled Magnetic Beads

Species

Homo sapiens (Human)
Human
Mus musculus (Mouse)
Rat
Rattus norvegicus (Rat)
Zebrafish

Source

E.coli
E.coli expression system
HEK293
In Vitro Cell Free System
Insect cells
Mammalian Cell
Wheat Germ

Tag

GST
His
His (Fc)
Avi
Myc|DDK
N/A

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	UGT1A6-208H	Recombinant Human UGT1A6, GST-tagged	Wheat Germ	GST		Inquiry
Human	UGT1A6-31663TH	Recombinant Human UGT1A6		N/A		Inquiry
Human	UGT1A6-12H	Recombinant Human UGT1A6 protein, MYC/DDK-tagged	HEK293	Myc/DDK		Inquiry
Human	UGT1A6-511HCL	Recombinant Human UGT1A6 293 Cell Lysate	HEK293	N/A		Inquiry
Human	UGT1A6-96H	Recombinant Human UGT1A6 Protein	Insect cells			Inquiry
Human	UGT1A6-2517H	Recombinant Human UGT1A6 protein, His-tagged	E.coli	His	176-488 aa	$319 / 25ug
Human	UGT1A6-540HF	Recombinant Full Length Human UGT1A6 Protein, GST-tagged	In Vitro Cell Free System	GST	532 amino acids	Inquiry
Rat	UGT1A6-6432R	Recombinant Rat UGT1A6 Protein	Mammalian Cell	His		Inquiry
Rat	UGT1A6-6088R	Recombinant Rat UGT1A6 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Rat	UGT1A6-6088R-B	Recombinant Rat UGT1A6 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Homo sapiens (Human)	RFL7834HF	Recombinant Full Length Human Udp-Glucuronosyltransferase 1-6(Ugt1A6) Protein, His-Tagged	E.coli expression system	His	Full Length of Mature Protein (27-532)	Inquiry
Mus musculus (Mouse)	RFL3207MF	Recombinant Full Length Mouse Udp-Glucuronosyltransferase 1-6(Ugt1A6) Protein, His-Tagged	E.coli expression system	His	Full Length of Mature Protein (27-531)	Inquiry
Rattus norvegicus (Rat)	RFL32553RF	Recombinant Full Length Rat Udp-Glucuronosyltransferase 1-6(Ugt1) Protein, His-Tagged	E.coli expression system	His	Full Length of Mature Protein (26-529)	Inquiry
Zebrafish	UGT1A6-7719Z	Recombinant Zebrafish UGT1A6	Mammalian Cell	His		Inquiry

Involved Pathway
Protein Function
Interacting Protein
UGT1A6 Related Articles

UGT1A6 involved in several pathways and played different roles in them. We selected most pathways UGT1A6 participated on our site, such as Pentose and glucuronate interconversions, Ascorbate and aldarate metabolism, Steroid hormone biosynthesis, which may be useful for your reference. Also, other proteins which involved in the same pathway with UGT1A6 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Pentose and glucuronate interconversions	DHDH;UGT1A3;AKR1B1;RPE;UGT1A2;UGDH;UGT1A7C;GUSB;UGT2B7
Ascorbate and aldarate metabolism	ALDH3A2;ALDH3A2A;MIOX;UGT1A9;UGT1A7C;UGT2A1;UGT1A1;UGT2B15;UGT1A4
Steroid hormone biosynthesis	UGT2B7;AKR1C2;CYP3A7;UGT2A2;CYP21A1;PPP1R2;UGT1A6;HSD17B2;UGT2A1
Starch and sucrose metabolism	UGT2B7;UGT1A2;UGT1A6A;AMY2B;UGT1AB;AMY2A;G6PC2;GAA;ENPP3
Retinol metabolism	CYP2C54;DHRS3;AOX4;AOX2P;DGAT1A;UGT2A2;RDH10;BCMO1;SDR16C5
Porphyrin and chlorophyll metabolism	COX10;UGT2B15;ALAS2;CPOX;BLVRB;UGT5G1;EARS2;UROS;UGT1A7C
Metabolism of xenobiotics by cytochrome P	GSTM2;CBR1;GSTM1;GSTA2;GSTT1B;UGT1A1;CBR3;GSTA4;UGT5G1
Drug metabolism - cytochrome P	ALDH1A3;GSTT1B;UGT1A7C;UGT1A6A;GSTM5;GSTM3;UGT1A4;AOX4;UGT1A6B
Drug metabolism - other enzymes	UGT2A1;UCK2A;UGT1A6;DPYS;CES2;NAT1;CYP2A6;UGT1A3;UGT2A3
Metabolic pathways	PNPLA3;G6PC2;NAT8L;CYP21A2;ST6GALNAC1;PI4KAA;POLR2I;HSD3B4;EXT1A
Chemical carcinogenesis	CYP2A13;SULT1A1;CYP2A6;SULT1A2;GSTT2B;PTGS2;CYP3A4;ADH2-2;UGT2A1

UGT1A6 has several biochemical functions, for example, enzyme binding, glucuronosyltransferase activity, NOT glucuronosyltransferase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by UGT1A6 itself. We selected most functions UGT1A6 had, and list some proteins which have the same functions with UGT1A6. You can find most of the proteins on our site.

Function	Related Protein
enzyme binding	RFC5;CLSTN2;STUB1;PPP3CB;TRAF2;TULP3;LAMB1;RPA2;SLC12A3
glucuronosyltransferase activity	EXT1;UGT1A3;UGT1AB;B3GNT1;UGT2A5;UGT1B4;UGT5B2;UGT1B1;UGT2B1
NOT glucuronosyltransferase activity	UGT1A3;UGT1A7;UGT1A9;UGT1A1;UGT1A4;UGT1A6
protein heterodimerization activity	H2AFV;LIFR;DRAP1;ANO2;HIST1H2BA;ADORA2A;SRI;NOTCH1;GABPB2
protein homodimerization activity	GM5506;DGCR8;CAV2;LMLN;SYT16;NTRK1;BMP4;NR4A2;OSTA
NOT retinoic acid binding	UGT2B7;UGT2B15;UGT1A4;UGT1A6

UGT1A6 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with UGT1A6 here. Most of them are supplied by our site. Hope this information will be useful for your research of UGT1A6.

Uchihashi, S; Nishikawa, M; et al. The critical role of amino acid residue at position 117 of mouse UDP-glucuronosyltransfererase 1a6a and 1a6b in resveratrol glucuronidation. JOURNAL OF BIOCHEMISTRY 152:331-340(2012).

Milne, AM; Burchell, B; et al. A Novel Method for the Immunoquantification of UDP-Glucuronosyltransferases in Human Tissue. DRUG METABOLISM AND DISPOSITION 39:2258-2263(2011).