usp15
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  • Official Full Name
  • ubiquitin specific peptidase 15
  • Background
  • This gene encodes a member of the ubiquitin specific protease (USP) family of deubiquitinating enzymes. USP enzymes play critical roles in ubiquitin-dependent processes through polyubiquitin chain disassembly and hydrolysis of ubiquitin-substrate bonds. The encoded protein associates with the COP9 signalosome, and also plays a role in transforming growth factor beta signalling through deubiquitination of receptor-activated SMAD transcription factors. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 2.
  • Synonyms
  • USP15; ubiquitin specific peptidase 15; ubiquitin specific protease 15; ubiquitin carboxyl-terminal hydrolase 15; KIAA0529; UNPH4; Deubiquitinating enzyme 15; Deubiquitinating enzyme; EC 3 1 2 15; MGC131982; MGC149838; MGC74854; Ubiquitin Carboxy terminal Hydrolase 15; Ubiquitin specific processing protease 15; Ubiquitin thioesterase 15; Ubiquitin thiolesterase 15; Ubiquitin-specific-processing protease 15; UBP 15; UBP15; UBP15_HUMAN; Unph 2; UNPH 4; Unph-2; Unph2; USP 15; OTTHUMP00000243156; OTTHUMP00000243158
Cat.#:USP15-357HTag:GST
Source (Host):BacterialSpecies:Human
Product nameRecombinant Human USP15 protein, GST-tagged
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Cat.#:USP15-358HTag:His
Source (Host):Spodoptera frugiperda, Sf 21 (baculovirus)Species:Human
Product nameRecombinant Human USP15 Protein, His-tagged
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Cat.#:USP15-361HTag:GST
Source (Host):BacteriaSpecies:Human
Product nameRecombinant Human USP15 Protein, GST-tagged
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Cat.#:USP15-682HTag:Myc|DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human USP15 Protein, MYC/DDK-tagged
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Cat.#:USP15-148HTag:His|SUMO
Source (Host):E.coliSpecies:Human
Product nameRecombinant Human USP15, His-SUMO-tagged
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Cat.#:USP15-15881HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human USP15, His-tagged
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Cat.#:USP15-185HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human USP15
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Cat.#:USP15-17904MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse USP15 Protein
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Cat.#:USP15-6470RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat USP15 Protein
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Cat.#:USP15-5122RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey USP15 Protein, His-tagged
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Cat.#:USP15-6403CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken USP15
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Involved Pathway

USP15 involved in several pathways and played different roles in them. We selected most pathways USP15 participated on our site, such as Downregulation of TGF-beta receptor signaling, Integrated Breast Cancer Pathway, Signal Transduction, which may be useful for your reference. Also, other proteins which involved in the same pathway with USP15 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Downregulation of TGF-beta receptor signaling
STUB1; USP15; PMEPA1; STRAP; UCHL5; SMAD3B
Integrated Breast Cancer Pathway
SMARCA4; APOBEC3G; ERAL1; NOXA1; RPP38; GRN; NAB1; USP38; EDAR; GDI1
Signal Transduction
ARHGAP10; METAP2A; CDON; PNOC; DLK1; BCO2A; AMOTL2A; GDI2; OPN4B; OXGR1A.3
Signaling by TGF-beta Receptor Complex
USP9; UCHL5; SKIA; SKIB; NEDD8; CGNB; STRAP; USP15; PMEPA1; USP9X
TGF-beta receptor signaling activates SMADs
PMEPA1; UCHL5; NEDD8; USP15; STRAP; NEDD8L

Protein Function

USP15 has several biochemical functions, for example, SMAD binding, cysteine-type endopeptidase activity, identical protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by USP15 itself. We selected most functions USP15 had, and list some proteins which have the same functions with USP15. You can find most of the proteins on our site.
Function
Related Protein
Function SMAD binding
Related Protein SKOR1A; COL1A2; SOD3; TGFBR2; PURB; YY1; ACVR1B; BMPR1A; TGFBRAP1; SKILB
Function cysteine-type endopeptidase activity
Related Protein USP16; BLMH; Casp3; USP38; CTSL2; USP25; CASPB; USP2A; USP5; USP19
Function identical protein binding
Related Protein USP15; GRIN3A; DESI1; C1QL2; HCN2; SLC2A1; BCAT1; EIF2AK3; HAND2; DRG1
Function protein binding
Related Protein SLAMF6; JAK1; ZDHHC17; TPD52L1; NSF; SIN3A; FGD5; TET3; TUBA1C; FCHSD2
Function transforming growth factor beta receptor binding
Related Protein BMP2B; TGFB2; MSTNB; FKBP1A; NDR2; GDF10; LEFTY1; INHBAA; USP15; INHBE
Function ubiquitin-specific protease activity
Related Protein OTUB1A; OTUD1; FAM105B; USP4; USP43A; MYSM1; CYLD; USP22; ATXN3L; USP15
Function ubiquitinated histone binding
Related Protein USP15

Interacting Protein

USP15 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with USP15 here. Most of them are supplied by our site. Hope this information will be useful for your research of USP15.
TRIM21; CCDC57; SPDL1; CARD9; MAD1L1