usp5
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  • Official Full Name
  • ubiquitin specific peptidase 5 (isopeptidase T)
  • Background
  • Ubiquitin (see MIM 191339)-dependent proteolysis is a complex pathway of protein metabolism implicated in such diverse;cellular functions as maintenance of chromatin structure, receptor function, and degradation of abnormal proteins. A;late step of the process involves disassembly of the polyubiquitin chains on degraded proteins into ubiquitin;monomers. USP5 disassembles branched polyubiquitin chains by a sequential exo mechanism, starting at the proximal end;of the chain (Wilkinson et al., 1995 (PubMed 7578059)).
  • Synonyms
  • USP5; ubiquitin specific peptidase 5 (isopeptidase T); ubiquitin specific protease 5 (isopeptidase T); ubiquitin carboxyl-terminal hydrolase 5; IsoT; isopeptidase T; ubiquitin isopeptidase T; ubiquitin thioesterase 5; deubiquitinating enzyme 5; ubiquitin
Cat.#:USP5-681HTag:Myc|DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human USP5 Protein, MYC/DDK-tagged
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Cat.#:USP5-1182HTag:His
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human USP5, His tagged
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Cat.#:USP5-158HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human USP5 protein, His-tagged
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Cat.#:USP5-3633HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human USP5, GST-tagged
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Cat.#:USP5-17937MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse USP5 Protein
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Cat.#:USP5-5130RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey USP5 Protein, His-tagged
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Cat.#:USP5-12776ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish USP5
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Cat.#:USP5-561HCLTag:N/A
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human USP5 cell lysate
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Protein Function

USP5 has several biochemical functions, for example, cysteine-type endopeptidase activity, omega peptidase activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by USP5 itself. We selected most functions USP5 had, and list some proteins which have the same functions with USP5. You can find most of the proteins on our site.
Function
Related Protein
Function cysteine-type endopeptidase activity
Related Protein DUB1; CTSL1; USP50; CTSC; MALT1; USP17L2; CTSBB; USP51; USP31; CASP2
Function omega peptidase activity
Related Protein UCHL1; USP5; JOSD2; GGH; APEH; USP13; UCHL5; JOSD1; ATXN3L; ATXN3
Function protein binding
Related Protein ANKRD49; PITX2; CDYL2; RAI2; TCP1; CATSPER1; CELF1; LRRC29; EXOSC2; ACTG1
Function ubiquitin binding
Related Protein UBXN2A; PARK2; USP13; TRIM32; HSPB1; AUP1; RBCK1; CXCR4; TRP53INP2; NBR1
Function ubiquitin-specific protease activity
Related Protein USP19; OTUD3; USP25; USP2A; ZRANB1B; UCHL1; FMNL3; USP12A; USP3; USP48
Function zinc ion binding
Related Protein NR2F5; CIZ1; TRIM3B; TRIM4; MARCH5; MORC3A; DYTN; ZDHHC5A; MMP25; ZFP326

Interacting Protein

USP5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with USP5 here. Most of them are supplied by our site. Hope this information will be useful for your research of USP5.
DAZAP2; TMEM239; TADA3; UBC; ub6l2_human; RAD23B; USP13; TNFRSF10D; PRKAB1; DVL2; RNF11