VAV1
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Official Full Name
VAV1 vav 1 guanine nucleotide exchange factor -
Synonyms
VAV1;vav 1 guanine nucleotide exchange factor;VAV, vav 1 oncogene;proto-oncogene vav;vav 1 oncogene;VAV
Recombinant Proteins
- Human
- Mouse
- E.coli
- Bacteria
- Sf9 Cells
- HEK293
- Mammalian Cells
- His
- GST
- Non
- Avi
- Fc
- DDK
- Myc
- Flag
Involved Pathway
VAV1 involved in several pathways and played different roles in them. We selected most pathways VAV1 participated on our site, such as cAMP signaling pathway,Chemokine signaling pathway,Focal adhesion, which may be useful for your reference. Also, other proteins which involved in the same pathway with VAV1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| B Cell Receptor Signaling Pathway | ARPC4,FCGR2B,CD22,SOS1,HDAC5,PIK3R5,KRAS,NFATC1,PIK3CB,AKT1 |
| Leukocyte transendothelial migration | CXCL12,ROCK2,CDH5,ITGB1,CLDN6,RHOH,ACTB,VAV2,PECAM1,PIK3R5 |
| Focal adhesion | LAMB3,TNXB,ACTN4,FYNB,BCL2,PDGFC,PIK3R3A,PXNA,PRKCA,FLNB |
| T cell receptor signaling pathway | CD4,MAP2K1,DLG1,PPP3R1,TEC,NFKB1,RAF1,CD3G,ICOS,MAP2K2 |
| cAMP signaling pathway | PIK3CA,PLD2,GIPR,PDE4B,MC2R,NPY,BDNF,NFKB1,PDE4D,FSHB |
| Regulation of Actin Cytoskeleton | ITGAM,PDGFD,PPP1CA,ITGA9,PAK2B,FGF4,F2,FGFR4,RAC3A,MYLPFA |
| Fc epsilon RI signaling pathway | MAPK13,VAV3,LAT,TNF,IL5,FCER1G,MAPK3,PLCG1,RAC2,FYN |
| Natural killer cell mediated cytotoxicity | PTPN6,SH3BP2,IFNA17,KLRD1,PLCG1,ITGB2L,PIK3CA,MAP2K2,H60a,IFNA12 |
| Fc gamma R-mediated phagocytosis | WASF3,MARCKSL1,LAT,PIK3R1,GAB2,LIMK2,PLA2G4F,WASL,CDC42,NCF1 |
Protein Function
VAV1 has several biochemical functions, for example, Rac guanyl-nucleotide exchange factor activity,guanyl-nucleotide exchange factor activity,metal ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by VAV1 itself. We selected most functions VAV1 had, and list some proteins which have the same functions with VAV1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| guanyl-nucleotide exchange factor activity | DENND5B,RAPGEF5B,BCAR3,RASGRP3,DOCK1,ARHGEF19,P2RY12,TAGAP,PTGIR,PCP2 |
| transcription factor activity, sequence-specific DNA binding | CBL,PRRX2,TADA3,TBR1,IRF5,TAF1B,NFIL3,TRIM22,DMRT1,POU4F2 |
| metal ion binding | TRIM27,PRUNE,HMOX1A,SLX1B,PPM1LA,ZFP704,AGFG1A,ZFP260,FHL1A,ZNF493 |
| protein binding | LRP2BP,COG1,SMC4,CEP76,ATG5,USP13,CMTM2A,SLC9A3R2,DNM3,SERPINA3 |
| Rac guanyl-nucleotide exchange factor activity | ALS2,DOCK2,ARHGEF2,FARP1,SPATA13,VAV3,FARP2,PREX2,ARHGEF4 |
Interacting Protein
VAV1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with VAV1 here. Most of them are supplied by our site. Hope this information will be useful for your research of VAV1.
SH3BP2;LCP2;ABL1
VAV1 Related Signal Pathway
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