vdac2
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  • Official Full Name
  • voltage-dependent anion channel 2
  • Background
  • This gene encodes a member of the voltage-dependent anion channel pore-forming family of proteins that are considered the main pathway for metabolite diffusion across the mitochondrial outer membrane. The encoded protein is also thought to be involved in the mitochondrial apoptotic pathway via regulation of BCL2-antagonist/killer 1 protein activity. Pseudogenes have been identified on chromosomes 1, 2, 12 and 21, and alternative splicing results in multiple transcript variants.
  • Synonyms
  • VDAC2; voltage-dependent anion channel 2; voltage-dependent anion-selective channel protein 2; outer mitochondrial membrane protein porin 2; POR; FLJ23841
Cat.#:VDAC2-3658HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human VDAC2, GST-tagged
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Cat.#:VDAC2-18001MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse VDAC2 Protein
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Cat.#:VDAC2-6511RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat VDAC2 Protein
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Cat.#:VDAC2-5151RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey VDAC2 Protein, His-tagged
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Cat.#:VDAC2-6306CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken VDAC2
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Cat.#:VDAC2-9988ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish VDAC2
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Cat.#:VDAC2-418HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human VDAC2 293 Cell Lysate
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Involved Pathway

VDAC2 involved in several pathways and played different roles in them. We selected most pathways VDAC2 participated on our site, such as Calcium signaling pathway, cGMP-PKG signaling pathway, Parkinsons disease, which may be useful for your reference. Also, other proteins which involved in the same pathway with VDAC2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Calcium signaling pathway
CCKAR; RYR2; P2RX3; PLCD3A; PLCD1; ADRB2B; ITPR1; PPIFB; RYR3; ADORA2B
cGMP-PKG signaling pathway
IRS2; PDE5A; GNAI1; PDE3A; PPP3R2; CREB3L2; SLC25A6; MYLK4; CREB5; PPP3CB
Parkinsons disease
Atp5g2; NDUFV1; NDUFB11; NDUFB8; COX7A1; COX5A; ATP5G1; UCHL1; ATP5C1; NDUFA8
Huntingtons disease
COX5B; GRIN1; ATP5A1; HIP1; COX7A1; CREB3L2; TRP53; POLR2F; CREB3L3; COX8A
HTLV-I infection
HRAS; WNT7B; CDC20; CRTC2; POLB; PCNA; WNT2; DVL2; RANBP1; PPP3CB

Protein Function

VDAC2 has several biochemical functions, for example, nucleotide binding, porin activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by VDAC2 itself. We selected most functions VDAC2 had, and list some proteins which have the same functions with VDAC2. You can find most of the proteins on our site.
Function
Related Protein
Function nucleotide binding
Related Protein CHD8; EGFRA; NLRP4E; CTPS1A; SRSF2; ABCD3; PRKACBA; CKBB; PIP5K2; FUS
Function porin activity
Related Protein TOMM40; AQP9; TOMM40L; VDAC1; VDAC2; VDAC3
Function protein binding
Related Protein EDF1; SPATA8; PHB; ZDHHC13; CDC42EP2; AP1M2; TERF2; AKAP12; FAM154A; BLNK
Function voltage-gated anion channel activity
Related Protein VDAC1; VDAC3; GPR89; SLC17A3; VDAC2

Interacting Protein

VDAC2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with VDAC2 here. Most of them are supplied by our site. Hope this information will be useful for your research of VDAC2.
FAM162A; env; env; ACTB; DHRS2; CLN3; SERINC3; BAK1; TRAF6; q81y32_bacan; atoE; Trappc11; 15-deoxy-delta(12,14; MTX2; Mtx2; MME; ATF2

VDAC2 Related Articles

Chang, JS; Chi, SC; et al. GHSC70 Is Involved in the Cellular Entry of Nervous Necrosis Virus. JOURNAL OF VIROLOGY 89:61-70(2015).
Petit, FM; Serres, C; et al. Moonlighting proteins in sperm-egg interactions. BIOCHEMICAL SOCIETY TRANSACTIONS 42:1740-1743(2014).