wnt6
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  • Official Full Name
  • wingless-type MMTV integration site family, member 6
  • Background
  • The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It is overexpressed in cervical cancer cell line and strongly coexpressed with another family member, WNT10A, in colorectal cancer cell line. The gene overexpression may play key roles in carcinogenesis. This gene and the WNT10A gene are clustered in the chromosome 2q35 region. The protein encoded by this gene is 97% identical to the mouse Wnt6 protein at the amino acid level. [provided by RefSeq, Jul 2008]
  • Synonyms
  • WNT6; wingless-type MMTV integration site family, member 6; protein Wnt-6;
Cat.#:WNT6-12HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human WNT6 Protein, GST-tagged
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Cat.#:WNT6-18575MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse WNT6 Protein
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Cat.#:WNT6-1746CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken WNT6
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Cat.#:WNT6-290HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human WNT6 293 Cell Lysate
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Involved Pathway

WNT6 involved in several pathways and played different roles in them. We selected most pathways WNT6 participated on our site, such as Wnt signaling pathway, Hedgehog signaling pathway, Hippo signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with WNT6 were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Wnt signaling pathway
PLCB2; FOSL1; CCND2A; RAC2; CTNNBIP1; PRKACBA; DAAM1; WNT10B; PRKACAB; EP300
Hedgehog signaling pathway
BMP2; IHHB; GSK3B; WNT5A; WNT7B; PRKACAA; HHIP; WNT6; PTCH1; GAS1
Hippo signaling pathway
WNT6; BMPR1B; CCND1; MPP5; LATS1; AMH; CRB2; PPP2R2A; TEAD2; PPP1CB
Signaling pathways regulating pluripotency of stem cells
STAT3; LIF; ONECUT1; LHX5; BMI1; HRAS; GRB2; IGF1R; INHBA; LIFR
Melanogenesis
TCF7L1A; RAF1A; CAMK2D; MITFB; CAMK2B; PLCB2; CAMK2B1; GNAO1A; KITLGA; FZD9
HTLV-I infection
SLC2A1; DVL1; RB1; BCL2L1; PIK3CG; WNT11; LTA; RELB; EGR1; MYBL1
Pathways in cancer
PTGS2; TRAF3; TRAF1; LPAR4; GNG3; FGFR1; ZBTB16; GNG11; BCL2; TGFB1
Proteoglycans in cancer
PRKCA; TWIST2; SDC1; FZD7; MAPK1; CD44; NRAS; ANK1; IL12B; HGF
Basal cell carcinoma
WNT9A; TCF7L2; WNT5B; PTCH1; FZD3; TRP53; FZD5; WNT3; LEF1; WNT7B

Protein Function

WNT6 has several biochemical functions, for example, frizzled binding. Some of the functions are cooperated with other proteins, some of the functions could acted by WNT6 itself. We selected most functions WNT6 had, and list some proteins which have the same functions with WNT6. You can find most of the proteins on our site.
Function
Related Protein
Function frizzled binding
Related Protein WNT7AA; NDP; DVL3; LRP6; WNT5B; DVL2; FZD7; WNT2BB; WNT9A; WNT5A

WNT6 Related Gene Family

WNT