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WNT6

  • Official Full Name

    wingless-type MMTV integration site family, member 6

  • Overview

    The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It is overexpressed in cervical cancer cell line and strongly coexpressed with another family member, WNT10A, in colorectal cancer cell line. The gene overexpression may play key roles in carcinogenesis. This gene and the WNT10A gene are clustered in the chromosome 2q35 region. The protein encoded by this gene is 97% identical to the mouse Wnt6 protein at the amino acid level. [provided by RefSeq, Jul 2008]
  • Synonyms

    WNT6; wingless-type MMTV integration site family, member 6; protein Wnt-6;

  • Cell & Tissue Lysates
  • Recombinant Proteins
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Mouse
  • E. coli
  • HEK293
  • In Vitro Cell Free System
  • Mammalian Cell
  • Wheat Germ
  • GST
  • His
  • His (Fc)
  • Avi
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human WNT6-290HCL Recombinant Human WNT6 293 Cell Lysate HEK293 N/A
Human WNT6-120H Recombinant Human WNT6 Protein E. coli
Human WNT6-12H Recombinant Human WNT6 Protein, GST-tagged Wheat Germ GST
Human WNT6-6263HF Recombinant Full Length Human WNT6 Protein, GST-tagged In Vitro Cell Free System GST 365 amino acids
Mouse WNT6-18575M Recombinant Mouse WNT6 Protein Mammalian Cell His
Mouse WNT6-10200M-B Recombinant Mouse WNT6 Protein Pre-coupled Magnetic Beads HEK293
Mouse WNT6-10200M Recombinant Mouse WNT6 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Chicken WNT6-1746C Recombinant Chicken WNT6 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • WNT6 Related Gene Family
  • WNT6 Related Research Area
  • WNT6 Related Signal Pathway

WNT6 involved in several pathways and played different roles in them. We selected most pathways WNT6 participated on our site, such as Wnt signaling pathway, Hedgehog signaling pathway, Hippo signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with WNT6 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Wnt signaling pathwayRAC1B;SFRP1A;MAPK8;SMAD3;RHOA;CAMK2B1;FZD9B;PRKACB;VANGL2
Hedgehog signaling pathwayWNT7A;WNT4;WNT10B;SAP18;IHHB;GAS1;ZIC2;SKIA;HHIP
Hippo signaling pathwayWNT6;SAV1;CCND3;PPP2R1A;YWHAB;WNT11;YWHAG;AXIN2;CTNNA2
Signaling pathways regulating pluripotency of stem cellsDLX5;WNT10B;SMAD5;ONECUT1;SMAD3;WNT8B;WNT3;KLF4;INHBC
MelanogenesisCALM1A;MITFB;FZD3A;WNT2BA;TYR;CALM2B;PRKCBA;DVL3A;WNT6
HTLV-I infectionWNT10B;IL2RG;HLA-DRA;MYBL1;PDGFRB;ANAPC5;HLA-DRB1;Adcy4;XIAP
Pathways in cancerSLC2A1;MET;ARHGEF1;TPR;GNG12;LAMB1;PTEN;FH;CBLC
Proteoglycans in cancerFZD1;ANK2;ANK1;AKT1;DDX5;ERBB4;HPSE2;WNT2;WNT6
Basal cell carcinomaWNT2B;BMP4;GLI3;Shh;SMO;PTCH1;WNT2;SUFU;GLI2

WNT6 has several biochemical functions, for example, frizzled binding. Some of the functions are cooperated with other proteins, some of the functions could acted by WNT6 itself. We selected most functions WNT6 had, and list some proteins which have the same functions with WNT6. You can find most of the proteins on our site.

Function Related Protein
frizzled bindingWNT10B;MYOC;LRP6;WNT11R;CTHRC1;WNT11;WNT4;WNT2BB;WNT2

WNT6 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with WNT6 here. Most of them are supplied by our site. Hope this information will be useful for your research of WNT6.

WNT
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