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XCR1

  • Official Full Name

    chemokine (C motif) receptor 1

  • Overview

    The protein encoded by this gene is a chemokine receptor belonging to the G protein-coupled receptor superfamily. The family members are characterized by the presence of 7 transmembrane domains and numerous conserved amino acids. This receptor is most closely related to RBS11 and the MIP1-alpha/RANTES receptor. It transduces a signal by increasing the intracellular calcium ions level. The viral macrophage inflammatory protein-II is an antagonist of this receptor and blocks signaling. Two alternatively spliced transcript variants encoding the same protein have been found for this gene.
  • Synonyms

    XCR1; chemokine (C motif) receptor 1; CCXCR1, chemokine (C motif) XC receptor 1 , GPR5; chemokine XC receptor 1; lymphotactin receptor; XC chemokine receptor 1; G protein-coupled receptor 5; G-protein coupled receptor 5; chemokine (C motif) XC receptor 1;

  • Cell & Tissue Lysates
  • Recombinant Proteins
  • Transfected Stable Cell Lines
  • Chromatography Reagents
  • Chicken
  • Homo sapiens (Human)
  • Human
  • Mouse
  • Mus musculus (Mouse)
  • Chem-4
  • E.coli
  • E.coli expression system
  • HEK293
  • Mammalian Cell
  • His
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human XCR1-266HCL Recombinant Human XCR1 293 Cell Lysate HEK293 N/A
Human XCR1-0182H Active Recombinant Human XCR1 Full Length Transmembrane protein(Nanodisc) HEK293 N/A
Human CSC-RG0645 Human XCR1/Galpha15 Stable Cell Line-Chem-4 Chem-4 N/A
Mouse Xcr1-585M Recombinant Mouse Xcr1 protein, His-tagged E.coli His Thr244~Tyr322
Mouse XCR1-5002M XCR1 Antibody-coupled magnetic MicroBeads
Homo sapiens (Human) RFL19172HF Recombinant Full Length Human Chemokine Xc Receptor 1(Xcr1) Protein, His-Tagged E.coli expression system His Full Length (1-333)
Mus musculus (Mouse) RFL11018MF Recombinant Full Length Mouse Chemokine Xc Receptor 1(Xcr1) Protein, His-Tagged E.coli expression system His Full Length (1-322)
Chicken XCR1-3497C Recombinant Chicken XCR1 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • XCR1 Related Articles
  • XCR1 Related Gene Family
  • XCR1 Related Research Area

XCR1 involved in several pathways and played different roles in them. We selected most pathways XCR1 participated on our site, such as Cytokine-cytokine receptor interaction, Chemokine signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with XCR1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Cytokine-cytokine receptor interactionIl23a; Il12b;IL-8;CXCL8B.3;OSM;BMPR1BA;EDAR;Ccl21a;IL1RAP;CCL22
Chemokine signaling pathwayGM13306;ARRB2;CCL3;PIK3CD;ADRBK2;GNB3;RAC1;CCR5;WASL

XCR1 has several biochemical functions, for example, chemokine receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by XCR1 itself. We selected most functions XCR1 had, and list some proteins which have the same functions with XCR1. You can find most of the proteins on our site.

Function Related Protein
chemokine receptor activityPRLH2R;RGRB;CCR1L1;CXCR3;CCR5;CX3CR1;CMKLR1;CXCR3.1;CCR3

XCR1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with XCR1 here. Most of them are supplied by our site. Hope this information will be useful for your research of XCR1.

Fossum, E; Grodeland, G; et al. Vaccine molecules targeting Xcr1 on cross-presenting DCs induce protective CD8(+) T-cell responses against influenza virus. EUROPEAN JOURNAL OF IMMUNOLOGY 45:624-635(2015).
Hartung, E; Becker, M; et al. Induction of Potent CD8 T Cell Cytotoxicity by Specific Targeting of Antigen to Cross-Presenting Dendritic Cells In Vivo via Murine or Human XCR1. JOURNAL OF IMMUNOLOGY 194:1069-1079(2015).
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