YAP1
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Official Full Name
Yes-associated protein 1
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Overview
This gene encodes a downstream nuclear effector of the Hippo signaling pathway which is involved in development, growth, repair, and homeostasis. This gene is known to play a role in the development and progression of multiple cancers as a transcriptional regulator of this signaling pathway and may function as a potential target for cancer treatment. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Aug 2013] -
Synonyms
YAP1; Yes-associated protein 1; YAP; YKI; YAP2; YAP65; yorkie homolog; yes-associated protein 2; 65 kDa Yes-associated protein;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Chicken
- Human
- Mouse
- Rat
- Zebrafish
- E.coli
- HEK293
- HEK293T
- In Vitro Cell Free System
- Mamanlian cells
- Mammalian Cell
- Wheat Germ
- Yeast
- Flag
- GST
- His
- His (Fc)
- Avi
- B2M
- Myc
- DDK
- Myc|DDK
- N/A
- N
- Tag Free
- Involved Pathway
- Protein Function
- Interacting Protein
- YAP1 Related Articles
- YAP1 Related Research Area
- YAP1 Related Signal Pathway
YAP1 involved in several pathways and played different roles in them. We selected most pathways YAP1 participated on our site, such as ErbB4 signaling events, Fatty acid, triacylglycerol, and ketone body metabolism, Gene Expression, which may be useful for your reference. Also, other proteins which involved in the same pathway with YAP1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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ErbB4 signaling events | WWOX;CBFA2T3;WWP1;YAP1 |
Fatty acid, triacylglycerol, and ketone body metabolism | AGPAT2;SLC25A1;ECI1;MED25;ACSF3;ACOT6;MTF1;ACOT8;CYP4A11 |
Gene Expression | CLNS1A;PRDX2;TAF1B;NR2F6B;MADD;NR2E3;ZNF354B;ZNF266;EEF1E1 |
Generic Transcription Pathway | ZNF19;NR2F1;NR2F6;ZNF773;ZNF496;ZNF394;ARHGEF38;ZFP37;COX5B |
Hippo signaling pathway | BMP8B;SMAD7;WNT2B;BMP7;PPP2R2D;YWHAB;SERPINE1;PRKCZ;CCND2 |
Metabolism | PDK3;ACY3.1;SLC27A5;SLC16A1;SLC5A4;UGT1B2;GLS2B;CPT2;SLC25A2 |
Metabolism of lipids and lipoproteins | PPM1L;ACOT2;FA2H;GPAT2;CYP2AD3;FABP1B.1;BRSK2;NFYBA;INSIG1 |
Nuclear signaling by ERBB4 | CSH1;GHRB;YAP1;CSN2;PRLRB;WWOX;CSHL1 |
YAP1 has several biochemical functions, for example, RNA polymerase II core promoter sequence-specific DNA binding, chromatin binding, proline-rich region binding. Some of the functions are cooperated with other proteins, some of the functions could acted by YAP1 itself. We selected most functions YAP1 had, and list some proteins which have the same functions with YAP1. You can find most of the proteins on our site.
Function | Related Protein |
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RNA polymerase II core promoter sequence-specific DNA binding | ZFP335;SP1;FOS;H3F3B;ZNF335;EGR1;SP3;TRP53;TAL1 |
chromatin binding | SUV39H1;SP140;CRTC2;ELK4;LOXL2;POU5F3;POU1F1;BRD3;SKIL |
proline-rich region binding | GHR;GAREM;ABL1;CCND1;BAIAP2;BAIAP2L1;CYLD;ABI2;RABAC1 |
protein C-terminus binding | YWHAB;RBFOX1;PRKAA1;CTNNB1;HSPG2;NEIL1;PPP2CB;ATP2A2;CALCOCO1 |
protein binding | GUCY1A3;PAK1IP1;UFC1;ARHGAP9;SYK;EFCAB12;THRAA;PBX4;IRAK1BP1 |
transcription coactivator activity | NFE2;SUPT3H;PML;TADA2A;NCOA3;ENY2;COPS5;TFDP1;HTATIP2 |
transcription corepressor activity | WWTR1;GMNN;CBFA2T2;JAZF1;TOB1;NR1H4;PSMC3;TFAP2B;RELB |
transcription factor activity, RNA polymerase II transcription factor binding | ATF4;GATA4;GTF2E1;SRF;LHX2;MYOCD;MAMSTR;ZNF296;YAP1 |
transcription regulatory region DNA binding | SOX6;WT1;ZNF335;GABPB2;HIVEP3;BCL11B;BRCA1;TCF7L2;SOX17 |
YAP1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with YAP1 here. Most of them are supplied by our site. Hope this information will be useful for your research of YAP1.
CTNNB1; TEAD1; LATS1
- Q&As
- Reviews
Q&As (6)
Ask a questionThe research and development directions of antitumor drugs of YAP1 protein include inhibitors targeting YAP1, drugs that regulate the downstream signaling pathway of YAP1, and combination drug strategies.
YAP1 protein is regulated in multiple signaling pathways such as Wnt/β-catenin, Hippo, and FGF, thereby affecting cell proliferation and growth.
YAP1 protein plays a key role in the HIPPO signaling pathway, and its activation or inactivation affects cell proliferation, apoptosis, and differentiation.
YAP1 protein participates in tumor invasion and metastasis by regulating epithelial-mesenchymal transformation, cell migration and the expression of invasion-related factors.
The YAP1 protein is involved in regulating cell proliferation and growth, mainly through nuclear translocation and interaction with nuclear transcription factors to regulate the expression of related genes.
Post-translational modifications of YAP1 protein, such as phosphorylation and acetylation, can regulate its transcriptional activity and subcellular localization, thereby affecting tumor development.
Customer Reviews (3)
Write a reviewThis short half-life and high clearance of YAP1 allow it to penetrate the tissue and reach the lesion site, which improves the therapeutic effect.
The green production process of YAP1 not only improves the production efficiency, but also minimizes the environmental impact, truly realizing a win-win situation of economic and environmental benefits.
The potent biological activity of YAP1 combined with its high purity makes the experimental results highly reliable.
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