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ABCC2

  • Official Full Name

    ATP-binding cassette, sub-family C (CFTR/MRP), member 2

  • Overview

    Multi-drug resistance protein 2 (MRP2), also known as cMRP, cMOAT, and ABCC2, is an ATP binding cassette (ABC) transporter and part of the multi-drug resistance (MRP) family. The MRP proteins are membrane proteins that function as organic anion pumps invo
  • Synonyms

    ABCC2; ATP-binding cassette, sub-family C (CFTR/MRP), member 2; canalicular multispecific organic anion transporter 1 , CMOAT; canalicular multispecific organic anion transporter 1; cMRP; DJS; MRP2; canalicular multidrug resistance protein; multidrug resistance-associated protein 2; ATP-binding cassette sub-family C member 2; ABC30; CMOAT;

  • Recombinant Proteins
  • Protein Pre-coupled Magnetic Beads
  • Arabidopsis thaliana (Mouse-ear cress)
  • Cynomolgus Monkey
  • Human
  • Mouse
  • Rat
  • Rhesus Macaque
  • Zebrafish
  • E.coli
  • E.coli expression system
  • HEK293
  • Mammalian cell
  • Mammalian Cell
  • Sf9 Insect Cell
  • Wheat Germ
  • eGFP, Strep II,10His
  • GST
  • His
  • His (Fc)
  • Avi
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human ABCC2-2537H Recombinant Human ABCC2 Sf9 Insect Cell N/A
Human ABCC2-9216H Recombinant Human ABCC2, GST-tagged E.coli GST 193-325a.a.
Human ABCC2-047H Recombinant Human ABCC2 Protein, GST-Tagged Wheat Germ GST
Human ABCC2-8117H Recombinant Human ABCC2 protein, His-tagged E.coli His Ile1300~Glu1534
Human ABCC2-0107H Recombinant Human ABCC2 Protein (M1-F1545), eGFP, Strep II, 10×His tagged Mammalian cell eGFP, Strep II,10His M1-F1545
Mouse ABCC2-1100M Recombinant Mouse ABCC2 Protein Mammalian Cell His
Mouse ABCC2-197M-B Recombinant Mouse ABCC2 Protein Pre-coupled Magnetic Beads HEK293
Mouse ABCC2-197M Recombinant Mouse ABCC2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat ABCC2-404R Recombinant Rat ABCC2 Protein Mammalian Cell His
Rat Abcc2-2538R Recombinant Rat Abcc2 Sf9 Insect Cell N/A
Rat ABCC2-59R-B Recombinant Rat ABCC2 Protein Pre-coupled Magnetic Beads HEK293
Rat ABCC2-59R Recombinant Rat ABCC2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Arabidopsis thaliana (Mouse-ear cress) RFL31491AF Recombinant Full Length Arabidopsis Thaliana Abc Transporter D Family Member 2, Chloroplastic(Abcc2) Protein, His-Tagged E.coli expression system His Full Length of Mature Protein (45-706)
Cynomolgus Monkey ABCC2-261C Recombinant Cynomolgus ABCC2 Protein, His-tagged Mammalian Cell His
Cynomolgus Monkey ABCC2-11C Recombinant Cynomolgus Monkey ABCC2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Cynomolgus Monkey ABCC2-11C-B Recombinant Cynomolgus Monkey ABCC2 Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque ABCC2-180R Recombinant Rhesus monkey ABCC2 Protein, His-tagged Mammalian Cell His
Rhesus Macaque ABCC2-9R Recombinant Rhesus Macaque ABCC2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque ABCC2-9R-B Recombinant Rhesus Macaque ABCC2 Protein Pre-coupled Magnetic Beads HEK293
Zebrafish ABCC2-10867Z Recombinant Zebrafish ABCC2 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • ABCC2 Related Articles

ABCC2 involved in several pathways and played different roles in them. We selected most pathways ABCC2 participated on our site, such as ABC transporters, ABC-family proteins mediated transport, Bile secretion, which may be useful for your reference. Also, other proteins which involved in the same pathway with ABCC2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
ABC transportersABCB5;ABCA8;ABCA4;ABCC10;ABCB6;ABCG2A;ABCD1;ABCA13;ABCA3
ABC-family proteins mediated transportEIF2S3;ABCC2;ABCC9;ABCE1;KCNJ11;ABCA7;ABCD3B;ABCG4B;CFTR
Bile secretionSLC27A5;ATP1B2;Abcb1b;SLCO1A4;HMGCR;ABCB1A;Car2;SLC51A;ATP1A2
Drug Induction of Bile Acid PathwayCYP7A1;NR1I3;SLC51B;SLCO1B1;ABCC2;NR1I2
Nuclear receptors in lipid metabolism and toxicityCYP27B1;NR1I2;RARGA;RARG;CYP24A1;NR1I3;RARGB;VDRB;CYP26A1
Transmembrane transport of small moleculesRHCG;SLC6A2;CLCN4-2;TTYH3;SLC31A1;SLC12A3;ATP11C;SLC7A3;ATP2C2

ABCC2 has several biochemical functions, for example, ATP binding, ATPase activity, coupled to transmembrane movement of substances, organic anion transmembrane transporter activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ABCC2 itself. We selected most functions ABCC2 had, and list some proteins which have the same functions with ABCC2. You can find most of the proteins on our site.

Function Related Protein
ATP bindingTHG1L;SUCLG2;PIP4K2A;EPHB3;ATAD2;ICK;PCXA;PAK6;PEX1
ATPase activity, coupled to transmembrane movement of substancesABCB6;ABCD3;ABCC9;ABCA8;ABCC1;Abcb1b;ABCG2A;ABCA1B;ABCG5
organic anion transmembrane transporter activityABCC3;SLC22A20;ABCC5;SLC22A23;SLCO1B3;SLCO1A5;SLCO1B2;SLCO1A2;ABCC2
protein bindingFASTKD5;A1CF;CFL2;P2RY6;LSM5;STEAP3;EFCAB4B;ZFYVE21;PARD6B
protein domain specific bindingCASKIN1;YWHABL;PRKCI;IGBP1;PHRF1;XPA;MRPL17;GNAI3;IPCEF1

ABCC2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ABCC2 here. Most of them are supplied by our site. Hope this information will be useful for your research of ABCC2.

NFKB1; AZIN1; MCPH1; SHANK3; UBQLN1

Reiner, Z; et al. Resistance and intolerance to statins. NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES 24:1057-1066(2014).
Haslam, IS; Simmons, NL; et al. Expression of the ABC transport proteins MDR1 (ABCB1) and BCRP (ABCG2) in bovine rumen. JOURNAL OF COMPARATIVE PHYSIOLOGY B-BIOCHEMICAL SYSTEMIC AND ENVIRONMENTAL PHYSIOLOGY 184:673-681(2014).
  • Q&As
  • Reviews

Q&As (15)

Ask a question
Can Cry1Ca reduce the drug resistance of ABCC2? 10/24/2022

Cry1Ca is a protein that belongs to the family of crystal (Cry) proteins produced by the bacterium Bacillus thuringiensis.Some reseachs show that Cry1Ca could decrease the transport function of ABCC2 in plant.

Can I use antibody for abcc2 to distinguish hepatocytes from other cells? 08/06/2022

What is the relationship between the genetic variation of transporter ABCC2 and drug-induced hyperbilirubinemia 03/10/2022

Carriage of the ABCC2 (MRP2) rs717620 T variant may increase the risk of hyperbilirubinemia and mortality in patients with DILI.

Is Dubin Johnson's syndrome hereditary? 09/26/2021

Yes, Dubin-Johnson syndrome (DJS) is a hereditary condition, which means it is passed down through families.

What are the causes for dubin johnson syndrome? 04/09/2021

Causes Dubin-Johnson syndrome is caused by changes in a gene known as ABCC2. The ABCC2 gene provides instructions for making a protein that transports certain substances out of cells so they can be released (excreted) from the body.

What transport does ABCC2 generally mediate 08/09/2020

ABCC2 and ABCC3 (also known as MRP2 and MRP3) mediate the transport of various conjugated organic anions, including many drugs, toxicants and endogenous compounds.

Where does ABCC2 most expression? 08/07/2019

ABCC2/Abcc2 (MRP2/Mrp2) is expressed at major physiological barriers, such as the canalicular membrane of liver cells, kidney proximal tubule epithelial cells, enterocytes of the small and large intestine, and syncytiotrophoblast of the placenta.

What molecules can ABCC2 generally transport? 08/07/2019

ABCC2/Abcc2 transports a variety of amphiphilic anions that belong to different classes of molecules, such as endogenous compounds (e.g., bilirubin-glucuronides), drugs, toxic chemicals, nutraceuticals, and their conjugates.

What's the polymorphism risk of ABCC2 c.-24C>T 03/09/2019

The ABCC2 c.-24C>T polymorphism is a likely risk factor for resistance to AEDs.

Does ABCC2 polymorphism reduce antiepileptic drug resistance? 09/16/2018

Some researchs show that the ABCC2 G1249A polymorphism is significantly associated with a decreased risk of AED resistance. However, further functional investigations are warranted to validate the association.

What diseases will ABCC2 defects cause 06/08/2018

Acquired or hereditary deficiency of ABCC2, the latter known as Dubin-Johnson syndrome in humans

What are the effects of an ABCC2 abnormality? 06/04/2018

It is possible that ABCC2/Abcc2 transport activity as well as inhibitor sensitivity could lead to a number of phenomena (e.g. a difference in the biliary excretion clearance, a delay in the elimination half-life from the circulating blood and toxic side effects on ABCC2 -mediated drug-drug interactions, such as drug-induced hyperbilirubinemia).

What drug resistance does ABCC2 cause 08/14/2017

Human ABCC2 is an ATP-binding cassette transporter involved in the export of endobiotics and xenobiotics. It is involved in cisplatin resistance in cancer cells, particularly in ovarian cancer.

In which cells ABCC2 generally exists 02/09/2017

ABCC2 is a member of the multidrug resistance protein subfamily localized exclusively to the apical membrane domain of polarized cells, such as hepatocytes, renal proximal tubule epithelia, and intestinal epithelia.

What's the role of ABCC2 in liver 09/12/2016

The hepatic ABCC2 pump contributes to the driving forces of bile flow.

Customer Reviews (3)

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Reviews
02/01/2023

    Complete packaging and fast transportation

    01/09/2022

      Good positioning effect

      04/23/2021

        Less clutter and clear background

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