ABCC2
-
Official Full Name
ATP-binding cassette, sub-family C (CFTR/MRP), member 2
-
Overview
Multi-drug resistance protein 2 (MRP2), also known as cMRP, cMOAT, and ABCC2, is an ATP binding cassette (ABC) transporter and part of the multi-drug resistance (MRP) family. The MRP proteins are membrane proteins that function as organic anion pumps invo -
Synonyms
ABCC2; ATP-binding cassette, sub-family C (CFTR/MRP), member 2; canalicular multispecific organic anion transporter 1 , CMOAT; canalicular multispecific organic anion transporter 1; cMRP; DJS; MRP2; canalicular multidrug resistance protein; multidrug resistance-associated protein 2; ATP-binding cassette sub-family C member 2; ABC30; CMOAT;
- Recombinant Proteins
- Protein Pre-coupled Magnetic Beads
- Arabidopsis thaliana (Mouse-ear cress)
- Cynomolgus Monkey
- Human
- Mouse
- Rat
- Rhesus Macaque
- Zebrafish
- E.coli
- E.coli expression system
- HEK293
- Mammalian cell
- Mammalian Cell
- Sf9 Insect Cell
- Wheat Germ
- eGFP, Strep II,10His
- GST
- His
- His (Fc)
- Avi
- N/A
- Involved Pathway
- Protein Function
- Interacting Protein
- ABCC2 Related Articles
ABCC2 involved in several pathways and played different roles in them. We selected most pathways ABCC2 participated on our site, such as ABC transporters, ABC-family proteins mediated transport, Bile secretion, which may be useful for your reference. Also, other proteins which involved in the same pathway with ABCC2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
---|---|
ABC transporters | ABCB5;ABCA8;ABCA4;ABCC10;ABCB6;ABCG2A;ABCD1;ABCA13;ABCA3 |
ABC-family proteins mediated transport | EIF2S3;ABCC2;ABCC9;ABCE1;KCNJ11;ABCA7;ABCD3B;ABCG4B;CFTR |
Bile secretion | SLC27A5;ATP1B2;Abcb1b;SLCO1A4;HMGCR;ABCB1A;Car2;SLC51A;ATP1A2 |
Drug Induction of Bile Acid Pathway | CYP7A1;NR1I3;SLC51B;SLCO1B1;ABCC2;NR1I2 |
Nuclear receptors in lipid metabolism and toxicity | CYP27B1;NR1I2;RARGA;RARG;CYP24A1;NR1I3;RARGB;VDRB;CYP26A1 |
Transmembrane transport of small molecules | RHCG;SLC6A2;CLCN4-2;TTYH3;SLC31A1;SLC12A3;ATP11C;SLC7A3;ATP2C2 |
ABCC2 has several biochemical functions, for example, ATP binding, ATPase activity, coupled to transmembrane movement of substances, organic anion transmembrane transporter activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ABCC2 itself. We selected most functions ABCC2 had, and list some proteins which have the same functions with ABCC2. You can find most of the proteins on our site.
Function | Related Protein |
---|---|
ATP binding | THG1L;SUCLG2;PIP4K2A;EPHB3;ATAD2;ICK;PCXA;PAK6;PEX1 |
ATPase activity, coupled to transmembrane movement of substances | ABCB6;ABCD3;ABCC9;ABCA8;ABCC1;Abcb1b;ABCG2A;ABCA1B;ABCG5 |
organic anion transmembrane transporter activity | ABCC3;SLC22A20;ABCC5;SLC22A23;SLCO1B3;SLCO1A5;SLCO1B2;SLCO1A2;ABCC2 |
protein binding | FASTKD5;A1CF;CFL2;P2RY6;LSM5;STEAP3;EFCAB4B;ZFYVE21;PARD6B |
protein domain specific binding | CASKIN1;YWHABL;PRKCI;IGBP1;PHRF1;XPA;MRPL17;GNAI3;IPCEF1 |
ABCC2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ABCC2 here. Most of them are supplied by our site. Hope this information will be useful for your research of ABCC2.
NFKB1; AZIN1; MCPH1; SHANK3; UBQLN1
- Q&As
- Reviews
Q&As (15)
Ask a questionCry1Ca is a protein that belongs to the family of crystal (Cry) proteins produced by the bacterium Bacillus thuringiensis.Some reseachs show that Cry1Ca could decrease the transport function of ABCC2 in plant.
Carriage of the ABCC2 (MRP2) rs717620 T variant may increase the risk of hyperbilirubinemia and mortality in patients with DILI.
Yes, Dubin-Johnson syndrome (DJS) is a hereditary condition, which means it is passed down through families.
Causes Dubin-Johnson syndrome is caused by changes in a gene known as ABCC2. The ABCC2 gene provides instructions for making a protein that transports certain substances out of cells so they can be released (excreted) from the body.
ABCC2 and ABCC3 (also known as MRP2 and MRP3) mediate the transport of various conjugated organic anions, including many drugs, toxicants and endogenous compounds.
ABCC2/Abcc2 (MRP2/Mrp2) is expressed at major physiological barriers, such as the canalicular membrane of liver cells, kidney proximal tubule epithelial cells, enterocytes of the small and large intestine, and syncytiotrophoblast of the placenta.
ABCC2/Abcc2 transports a variety of amphiphilic anions that belong to different classes of molecules, such as endogenous compounds (e.g., bilirubin-glucuronides), drugs, toxic chemicals, nutraceuticals, and their conjugates.
The ABCC2 c.-24C>T polymorphism is a likely risk factor for resistance to AEDs.
Some researchs show that the ABCC2 G1249A polymorphism is significantly associated with a decreased risk of AED resistance. However, further functional investigations are warranted to validate the association.
Acquired or hereditary deficiency of ABCC2, the latter known as Dubin-Johnson syndrome in humans
It is possible that ABCC2/Abcc2 transport activity as well as inhibitor sensitivity could lead to a number of phenomena (e.g. a difference in the biliary excretion clearance, a delay in the elimination half-life from the circulating blood and toxic side effects on ABCC2 -mediated drug-drug interactions, such as drug-induced hyperbilirubinemia).
Human ABCC2 is an ATP-binding cassette transporter involved in the export of endobiotics and xenobiotics. It is involved in cisplatin resistance in cancer cells, particularly in ovarian cancer.
ABCC2 is a member of the multidrug resistance protein subfamily localized exclusively to the apical membrane domain of polarized cells, such as hepatocytes, renal proximal tubule epithelia, and intestinal epithelia.
The hepatic ABCC2 pump contributes to the driving forces of bile flow.
Customer Reviews (3)
Write a reviewComplete packaging and fast transportation
Good positioning effect
Less clutter and clear background
Ask a Question for All ABCC2 Products
Required fields are marked with *
My Review for All ABCC2 Products
Required fields are marked with *